{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:45:36Z","timestamp":1773827136684,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:00:00Z","timestamp":1486166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:00:00Z","timestamp":1486166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Netw Model Anal Health Inform Bioinforma"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s13721-017-0147-8","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T17:17:50Z","timestamp":1486228670000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In silico characterization of hypothetical proteins obtained from Mycobacterium tuberculosis H37Rv"],"prefix":"10.1007","volume":"6","author":[{"given":"Utkarsh","family":"Raj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aman Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imlimaong","family":"Aier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritish Kumar","family":"Varadwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,4]]},"reference":[{"issue":"3","key":"147_CR1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215(3):403\u2013410","journal-title":"J Mol Biol"},{"issue":"11","key":"147_CR2","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1021\/ja01131a519","volume":"74","author":"GL Cantoni","year":"1952","unstructured":"Cantoni GL (1952) The nature of the active methyl donor formed enzymatically from l-methionine and adenosinetriphosphate1, 2. J Am Chem Soc 74(11):2942\u20132943","journal-title":"J Am Chem Soc"},{"issue":"1","key":"147_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13721-016-0132-7","volume":"5","author":"L Chowdhury","year":"2016","unstructured":"Chowdhury L, Khan MI, Deb K, Kamal S (2016) MetaG: a graph-based metagenomic gene analysis for big DNA data. Netw Model Anal Health Inform Bioinform 5(1):1\u201316","journal-title":"Netw Model Anal Health Inform Bioinform"},{"issue":"4","key":"147_CR4","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nprot.2007.131","volume":"2","author":"O Emanuelsson","year":"2007","unstructured":"Emanuelsson O, Brunak S, von Heijne G, Nielsen H (2007) Locating proteins in the cell using TargetP, SignalP and related tools. Nat Protoc 2(4):953\u2013971","journal-title":"Nat Protoc"},{"issue":"2","key":"147_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1054\/tube.2002.0328","volume":"82","author":"LM Fu","year":"2002","unstructured":"Fu LM, Fu-Liu CS (2002) Is Mycobacterium tuberculosis a closer relative to Gram-positive or Gram-negative bacterial pathogens? Tuberculosis 82(2):85\u201390","journal-title":"Tuberculosis"},{"issue":"1","key":"147_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-9-1","volume":"9","author":"A Garg","year":"2008","unstructured":"Garg A, Gupta D (2008) VirulentPred: a SVM based prediction method for virulent proteins in bacterial pathogens. BMC Bioinform 9(1):1","journal-title":"BMC Bioinform"},{"issue":"13","key":"147_CR7","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1093\/nar\/gkg563","volume":"31","author":"E Gasteiger","year":"2003","unstructured":"Gasteiger E, Gattiker A, Hoogland C, Ivanyi I, Appel RD, Bairoch A (2003) ExPASy: the proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res 31(13):3784\u20133788","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"147_CR8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1146\/annurev.bi.50.070181.001313","volume":"50","author":"K Geider","year":"1981","unstructured":"Geider K, Hoffmann-Berling H (1981) Proteins controlling the helical structure of DNA. Annu Rev Biochem 50(1):233\u2013260","journal-title":"Annu Rev Biochem"},{"issue":"4","key":"147_CR9","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1006\/jmbi.2001.5080","volume":"313","author":"J Gough","year":"2001","unstructured":"Gough J, Karplus K, Hughey R, Chothia C (2001) Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure. J Mol Biol 313(4):903\u2013919","journal-title":"J Mol Biol"},{"key":"147_CR10","unstructured":"Gupta P, Raj U, Varadwaj PK (2015) Computational intelligence in data mining. In: Jain LC, Behera HS, Mandal JK, Mohapatra DP (eds) Proceedings of the International Conference on CIDM, 20\u201321 December 2014, vol. 1, pp 447\u2013458. Springer, India"},{"key":"147_CR11","doi-asserted-by":"publisher","unstructured":"Gupta S, Singh Y, Kumar H, Raj U, Rao AR, Varadwaj PK. (2016) Identification of novel abiotic stress proteins in Triticum aestivum through functional annotation of hypothetical proteins. Interdiscip Sci Comput Life Sci. doi:10.1007\/s12539-016-0178-3","DOI":"10.1007\/s12539-016-0178-3"},{"issue":"14","key":"147_CR12","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1128\/JB.00166-10","volume":"192","author":"TR Ioerger","year":"2010","unstructured":"Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C (2010) Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. J Bacteriol 192(14):3645\u20133653","journal-title":"J Bacteriol"},{"key":"147_CR13","doi-asserted-by":"publisher","unstructured":"Kamal MS, Nimmy SF (2016) StrucBreak: a computational framework for structural break detection in DNA sequences. Interdiscip Sci Comput Life Sci. doi:10.1007\/s12539-016-0158-7","DOI":"10.1007\/s12539-016-0158-7"},{"key":"147_CR14","first-page":"1","volume":"31","author":"MS Kamal","year":"2016","unstructured":"Kamal MS, Nimmy SF, Parvin S (2016a) Performance evaluation comparison for detecting DNA structural break through big data analysis. Comput Syst Sci Eng 31:1\u201315","journal-title":"Comput Syst Sci Eng"},{"key":"147_CR15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.cmpb.2016.04.005","volume":"131","author":"S Kamal","year":"2016","unstructured":"Kamal S, Ripon SH, Dey N, Ashour AS, Santhi V (2016b) A MapReduce approach to diminish imbalance parameters for big deoxyribonucleic acid dataset. Comput Methods Programs Biomed 131:191\u2013206","journal-title":"Comput Methods Programs Biomed"},{"issue":"3","key":"147_CR16","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","volume":"305","author":"A Krogh","year":"2001","unstructured":"Krogh A, Larsson B, Von Heijne G, Sonnhammer EL (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305(3):567\u2013580","journal-title":"J Mol Biol"},{"key":"147_CR17","first-page":"050","volume":"1","author":"A Kumar","year":"2011","unstructured":"Kumar A, Shanmughavel P (2011) Computational annotation for hypothetical proteins of Mycobacterium tuberculosis. J Comput Sci Syst Biol 1:050\u2013062","journal-title":"J Comput Sci Syst Biol"},{"issue":"12","key":"147_CR18","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/S1357-2725(97)00085-X","volume":"29","author":"DS Latchman","year":"1997","unstructured":"Latchman DS (1997) Transcription factors: an overview. Int J Biochem Cell Biol 29(12):1305\u20131312","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"147_CR19","doi-asserted-by":"publisher","first-page":"7283","DOI":"10.3390\/ijms13067283","volume":"13","author":"GK Mazandu","year":"2012","unstructured":"Mazandu GK, Mulder NJ (2012) Functional prediction and analysis of Mycobacterium tuberculosis hypothetical proteins. Int J Mol Sci 13(6):7283\u20137302","journal-title":"Int J Mol Sci"},{"key":"147_CR20","doi-asserted-by":"publisher","unstructured":"Mishra S, Raj U, Varadwaj PK (2016) Annotation of hypothetical proteins: a functional genomics approach. In: Computational Biology and Bioinformatics, vol. 2016, CRC Press, pp 135\u2013158. doi:10.1201\/b20026-10","DOI":"10.1201\/b20026-10"},{"issue":"Suppl 10","key":"147_CR21","first-page":"37","volume":"4","author":"B Munksgaard","year":"2004","unstructured":"Munksgaard B (2004) Mycobacterium tuberculosis. Am J Transplant 4(Suppl 10):37\u201341","journal-title":"Am J Transplant"},{"issue":"6","key":"147_CR22","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.chom.2015.05.008","volume":"17","author":"S Nambi","year":"2015","unstructured":"Nambi S, Long JE, Mishra BB, Baker R, Murphy KC, Olive AJ, Nguyen HP, Shaffer SA, Sassetti CM (2015) The oxidative stress network of Mycobacterium tuberculosis reveals coordination between radical detoxification systems. Cell Host Microbe 17(6):829\u2013837","journal-title":"Cell Host Microbe"},{"issue":"13","key":"147_CR23","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1093\/bioinformatics\/btq249","volume":"26","author":"YY Nancy","year":"2010","unstructured":"Nancy YY, Wagner JR, Laird MR, Melli G, Rey S, Lo R, Dao P, Sahinalp SC, Ester M, Foster LJ, Brinkman FS (2010) PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes. Bioinformatics 26(13):1608\u20131615","journal-title":"Bioinformatics"},{"issue":"1","key":"147_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12862-015-0378-1","volume":"15","author":"L Noda-Garc\u00eda","year":"2015","unstructured":"Noda-Garc\u00eda L, Ju\u00e1rez-V\u00e1zquez AL, \u00c1vila-Arcos MC, Verduzco-Castro EA, Montero-Mor\u00e1n G, Gayt\u00e1n P, Carrillo-Tripp M, Barona-G\u00f3mez F (2015) Insights into the evolution of enzyme substrate promiscuity after the discovery of (\u03b2\u03b1) 8 isomerase evolutionary intermediates from a diverse metagenome. BMC Evol Biol 15(1):1","journal-title":"BMC Evol Biol"},{"issue":"3","key":"147_CR25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1600-0854.2005.00270.x","volume":"6","author":"LF Pemberton","year":"2005","unstructured":"Pemberton LF, Paschal BM (2005) Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic 6(3):187\u2013198","journal-title":"Traffic"},{"issue":"1","key":"147_CR26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.34040\/IJCB.5.1.2015.71","volume":"5","author":"S Rai","year":"2016","unstructured":"Rai S, Raj U, Tichkule S, Kumar H, Mishra S, Sharma N, Buddham R, Raghav D, Varadwaj PK (2016) Recent trends in in-silico drug discovery. Int J Comput Biol (IJCB) 5(1):54\u201376","journal-title":"Int J Comput Biol (IJCB)"},{"issue":"4","key":"147_CR27","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2174\/1573409912666151124234008","volume":"11","author":"U Raj","year":"2015","unstructured":"Raj U, Kumar H, KumarVaradwaj P (2015a) 3D structure generation, molecular dynamics and docking studies of IRHOM2 protein involved in cancer & rheumatoid arthritis. Curr Comput Aided Drug Des 11(4):325\u2013335","journal-title":"Curr Comput Aided Drug Des"},{"issue":"9","key":"147_CR28","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.7314\/APJCP.2015.16.9.3817","volume":"16","author":"U Raj","year":"2015","unstructured":"Raj U, Kumar H, Gupta S, Varadwaj PK (2015b) Novel DOT1L receptor natural inhibitors involved in mixed lineage leukemia: a virtual screening, molecular docking and dynamics simulation study. Asian Pac J Cancer Prev 16(9):3817\u20133825","journal-title":"Asian Pac J Cancer Prev"},{"key":"147_CR29","first-page":"1","volume":"20","author":"U Raj","year":"2015","unstructured":"Raj U, Kumar H, Gupta S, Varadwaj PK (2015c) Exploring dual inhibitors for STAT1 and STAT5 receptors utilizing virtual screening and dynamics simulation validation. J Biomol Struct Dyn 20:1\u20135","journal-title":"J Biomol Struct Dyn"},{"key":"147_CR30","first-page":"1","volume":"5","author":"U Raj","year":"2016","unstructured":"Raj U, Kumar H, Varadwaj PK (2016) Molecular docking and dynamics simulation study of flavonoids as BET bromodomain inhibitors. J Biomol Struct Dyn 5:1\u20132","journal-title":"J Biomol Struct Dyn"},{"issue":"3","key":"147_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4018\/IJRSDA.2016070101","volume":"3","author":"SH Ripon","year":"2016","unstructured":"Ripon SH, Kamal S, Hossain S, Dey N (2016) theoretical analysis of different classifiers under reduction rough data set: a brief proposal. Int J Rough Sets Data Anal (IJRSDA) 3(3):1\u201320","journal-title":"Int J Rough Sets Data Anal (IJRSDA)"},{"issue":"1","key":"147_CR32","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S1672-0229(06)60015-6","volume":"4","author":"S Saha","year":"2006","unstructured":"Saha S, Raghava GPS (2006) VICMpred: an SVM-based method for the prediction of functional proteins of Gram-negative bacteria using amino acid patterns and composition. Genom Proteom Bioinform 4(1):42\u201347","journal-title":"Genom Proteom Bioinform"},{"issue":"suppl 2","key":"147_CR33","doi-asserted-by":"publisher","first-page":"W244","DOI":"10.1093\/nar\/gki408","volume":"33","author":"J S\u00f6ding","year":"2005","unstructured":"S\u00f6ding J, Biegert A, Lupas AN (2005) The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res 33(suppl 2):W244\u2013W248","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"147_CR34","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1002\/prot.21018","volume":"64","author":"CS Yu","year":"2006","unstructured":"Yu CS, Chen YC, Lu CH, Hwang JK (2006) Prediction of protein subcellular localization. Proteins: Struct, Funct, Bioinf 64(3):643\u2013651","journal-title":"Proteins: Struct, Funct, Bioinf"},{"issue":"9","key":"147_CR35","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.dnarep.2006.05.020","volume":"5","author":"Y Zhang","year":"2006","unstructured":"Zhang Y, Rowley JD (2006) Chromatin structural elements and chromosomal translocations in leukemia. DNA Repair 5(9):1282\u20131297","journal-title":"DNA Repair"}],"container-title":["Network Modeling Analysis in Health Informatics and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13721-017-0147-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-017-0147-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-017-0147-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T08:16:09Z","timestamp":1744100169000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13721-017-0147-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,4]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["147"],"URL":"https:\/\/doi.org\/10.1007\/s13721-017-0147-8","relation":{},"ISSN":["2192-6662","2192-6670"],"issn-type":[{"value":"2192-6662","type":"print"},{"value":"2192-6670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,4]]},"assertion":[{"value":"28 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"5"}}