{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:52:31Z","timestamp":1761490351906},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Netw Model Anal Health Inform Bioinforma"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s13721-017-0157-6","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T23:50:37Z","timestamp":1505433037000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Topology of protein\u2013protein interaction network and edge reduction co-efficiency in VEGF signaling of breast cancer"],"prefix":"10.1007","volume":"6","author":[{"given":"Sharath","family":"Belenahalli Shekarappa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivananda","family":"Kandagalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan","family":"Gollapalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharath","family":"Basavapattana Rudresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thriveni","family":"Hanumanthappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjunatha","family":"Hanumanthappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"issue":"50","key":"157_CR1","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1038\/sj.onc.1209085","volume":"24","author":"DA Altomare","year":"2005","unstructured":"Altomare DA, Testa JR (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene 24(50):7455\u20137464","journal-title":"Oncogene"},{"issue":"2","key":"157_CR2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/bioinformatics\/btm554","volume":"24","author":"Y Assenov","year":"2008","unstructured":"Assenov Y, Ramirez F, Schelhorn SE, Lengauer T, Albrecht M (2008) Computing topological parameters of biological networks. Bioinformatics 24(2):282\u2013284","journal-title":"Bioinformatics"},{"key":"157_CR3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2105-4-2","volume":"4","author":"Gary D Bader","year":"2003","unstructured":"Bader Gary D, Hogue Christopher WV (2003) An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinform 4:2","journal-title":"BMC Bioinform"},{"key":"157_CR4","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","volume":"25","author":"G Bindea","year":"2009","unstructured":"Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, Fridman WH, Pages F, Trajanoski Z, Galon J (2009) ClueGo: a cytoscape plug-into decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 25:1091\u20131093","journal-title":"Bioinformatics"},{"key":"157_CR5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/bcr589","volume":"5","author":"N Boudreau","year":"2003","unstructured":"Boudreau N, Myers C (2003) Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment. Breast Cancer Res 5:140\u2013146","journal-title":"Breast Cancer Res"},{"key":"157_CR6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/1471-2407-9-432","volume":"9","author":"D Cao","year":"2009","unstructured":"Cao D, Hou M, Guan YS, Jiang M, Yang Y et al (2009) Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications. BMC Cancer 9:432","journal-title":"BMC Cancer"},{"key":"157_CR7","doi-asserted-by":"crossref","first-page":"W399","DOI":"10.1093\/nar\/gkn296","volume":"36","author":"D Cheng","year":"2008","unstructured":"Cheng D, Knox C, Young N, Stothard P, Damaraju S, Wishart DS (2008) PolySearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites. Nucleic Acids Res 36:W399\u2013W405","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 4","key":"157_CR8","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","volume":"8","author":"C-H Chin","year":"2014","unstructured":"Chin C-H, Chen S-H, Wu H-H, Ho C-W, Ko M-T, Lin C-Y (2014) CytoHubba: identifying hub objects and subnetworks from complex interactome. BMC Syst Biol 8(Suppl 4):S11","journal-title":"BMC Syst Biol"},{"key":"157_CR9","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1251827","volume":"343","author":"FJ Couch","year":"2014","unstructured":"Couch FJ, Nathanson KL, Offit K (2014) Two decades after BRCA: setting paradigms in personalized cancer care and prevention. Science 343:1466","journal-title":"Science"},{"key":"157_CR10","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1200\/JCO.2010.34.0778","volume":"29","author":"C Cybulski","year":"2011","unstructured":"Cybulski C, Wokolorczyk D, Jakubowska A, Huzarski T, Byrski T, Gronwald J (2011) Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer. J Clin Oncol 29:3747\u20133752","journal-title":"J Clin Oncol"},{"key":"157_CR11","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/427787a","volume":"427","author":"J Folkman","year":"2004","unstructured":"Folkman J, Kalluri R (2004) Cancer without disease. Nature 427:787","journal-title":"Nature"},{"issue":"5","key":"157_CR12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/molehr\/gam001","volume":"13","author":"D Gentilini","year":"2007","unstructured":"Gentilini D, Busacca M, Di Francesco S, Vignali M, Vigan\u00f2 P, Di Blasio AM (2007) PI3K\/Akt and ERK1\/2 signalling pathways are involved in endometrial cell migration induced by 17 beta-estradiol and growth factors. Mol Hum Reprod 13(5):317\u2013322","journal-title":"Mol Hum Reprod"},{"key":"157_CR13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2008","unstructured":"Huang DW, Sherman BT, Lempicki RA (2008) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44\u201357","journal-title":"Nat Protoc"},{"issue":"2","key":"157_CR14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69\u201390","journal-title":"CA Cancer J Clin"},{"key":"157_CR15","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s11033-011-1035-4","volume":"39","author":"H Jiang","year":"2012","unstructured":"Jiang H, Chen SS, Yang J, Chen J, He B, Zhu LH, Wang L (2012) CREB-binding protein silencing inhibits thrombin-induced endothelial progenitor cells angiogenesis. Mol Biol Rep 39:2773\u20132779","journal-title":"Mol Biol Rep"},{"issue":"18","key":"157_CR16","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1073\/pnas.0605874104","volume":"104","author":"X Ju","year":"2007","unstructured":"Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S, Zhou J, Turner J, Lisanti MP, Russell RG, Mueller SC, Ojeifo J, Chen WS, Hay N, Pestell RG (2007) Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci USA 104(18):7438\u20137443","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"157_CR17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330","journal-title":"Nucleic Acids Res"},{"key":"157_CR18","doi-asserted-by":"crossref","first-page":"13047","DOI":"10.1074\/jbc.M513033200","volume":"281","author":"HJ Kang","year":"2006","unstructured":"Kang HJ, Kim HJ, Rih JK, Mattson TL, Kim KW, Cho CH, Isaacs JS, Bae I (2006) BRCA1 plays a role in the hypoxic response by regulating HIF-1 stability and by modulating vascular endothelial growth factor expression. J Biol Chem 281:13047\u201313056","journal-title":"J Biol Chem"},{"key":"157_CR19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuroscience.2014.02.050","volume":"267","author":"Z Kang","year":"2014","unstructured":"Kang Z, Zhu H, Luan H, Han F, Jiang W (2014) Curculigoside A induces angiogenesis through VCAM-1\/Egr-3\/CREB\/VEGF signaling pathway. Neuroscience 267:232\u2013240","journal-title":"Neuroscience"},{"key":"157_CR20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13721-016-0123-8","volume":"5","author":"P Khurana","year":"2016","unstructured":"Khurana P, Tiwari D, Sugadev R, Sarkar S, Singh SB (2016) A comprehensive assessment of networks and pathways of hypoxia-associated proteins and identification of responsive protein modules. Netw Model Anal Health Inform Bioinform 5:17","journal-title":"Netw Model Anal Health Inform Bioinform"},{"key":"157_CR22","first-page":"1093","volume":"10","author":"P Li","year":"2014","unstructured":"Li P, Liu Y, Wang H, He Y, Wang X, He Y, Lv F, Chen H, Pang X, Liu M, Shi T, Yi Z (2014) PubAngioGen: a database and knowledge for angiogenesis and related diseases. Nucleic Acids Res 10:1093\u20131139","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"157_CR23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/bst0300173","volume":"30","author":"ME Maragoudakis","year":"2002","unstructured":"Maragoudakis ME, Tsopanoglou NE, Andriopoulou P (2002) Mechanism of thrombin-induced angiogenesis. Biochem Soc Trans 30(2):173\u2013177","journal-title":"Biochem Soc Trans"},{"key":"157_CR24","first-page":"111","volume":"7","author":"T Mukohara","year":"2015","unstructured":"Mukohara T (2015) PI3K mutations in breast cancer: prognostic and therapeutic implications. Breast Cancer 7:111\u2013123","journal-title":"Breast Cancer"},{"key":"157_CR25","first-page":"1523","volume":"151","author":"AM Petit","year":"1997","unstructured":"Petit AM, Rak J, Hung M-C, Rockwell P, Goldstein N, Fendly B, Kerbel RS (1997) Neutralizing antibodies against EGF and ErbB-2\/neu receptor tyrosine kinases down-regulate VEGF production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 151:1523\u20131530","journal-title":"Am J Pathol"},{"key":"157_CR26","first-page":"105","volume":"322","author":"GW Prager","year":"2012","unstructured":"Prager GW, Poettler M (2012) Angiogenesis in cancer. Basic mechanisms and therapeutic advances. Hamostaseologie 322:105\u2013114","journal-title":"Hamostaseologie"},{"key":"157_CR27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1759-4499-2-2","volume":"2","author":"K Raman","year":"2010","unstructured":"Raman K (2010) Construction and analysis of protein\u2013protein interaction networks. Autom Exp 2:2","journal-title":"Autom Exp"},{"key":"157_CR28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1752-0509-7-32","volume":"7","author":"J Ran","year":"2013","unstructured":"Ran J, Li H, Fu J, Liu L, Xing Y, Li X, Shen H, Chen Y, Jiang X, Li Y (2013) Construction and analysis of the protein\u2013protein interaction network related to essential hypertension. BMC Syst Biol 7:32","journal-title":"BMC Syst Biol"},{"key":"157_CR29","first-page":"963","volume":"57","author":"M Relf","year":"1997","unstructured":"Relf M, LeJeune S, Scott PA, Fox S, Smith K, Leek R (1997) Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 57:963\u2013969","journal-title":"Cancer Res"},{"issue":"7","key":"157_CR30","doi-asserted-by":"crossref","first-page":"e1000108","DOI":"10.1371\/journal.pcbi.1000108","volume":"4","author":"L Royer","year":"2008","unstructured":"Royer L, Reimann M, Andreopoulos B, Schroeder M (2008) Unravelling protein networks with power graph analysis. PLoS Comput Biol 4(7):e1000108","journal-title":"PLoS Comput Biol"},{"key":"157_CR31","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nature04209","volume":"437","author":"JF Rual","year":"2005","unstructured":"Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005) Towards a proteome-scale map of the human protein\u2013protein interaction network. Nature 437:1173\u20131178","journal-title":"Nature"},{"key":"157_CR32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(01)02354-7","volume":"495","author":"JJ Schuringa","year":"2001","unstructured":"Schuringa JJ, Schepers H, Vellenga E, Kruijer W (2001) Ser727\u2010dependent transcriptional activation by association of p300 with STAT3 upon IL\u20106 stimulation. FEBS Lett 495:71\u201376","journal-title":"FEBS Lett"},{"key":"157_CR33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/10409230091169186","volume":"352","author":"GL Semenza","year":"2000","unstructured":"Semenza GL (2000) Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 352:71\u2013103","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"11","key":"157_CR34","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504","journal-title":"Genome Res"},{"key":"157_CR35","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2015","unstructured":"Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, Kuhn M, Bork P, Jensen LJ, von Mering C (2015) STRING v10: protein\u2013protein interaction networks, integrated over the tree of life. Nucleic Acids Res 43:D447\u2013D452","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"157_CR36","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/cas.12813","volume":"106","author":"T Takeshita","year":"2015","unstructured":"Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Inao T, Sueta A, Fujiwara S, Omoto Y, Iwase H (2015) Prognostic role of PIK3CA mutations of cell-free DNA in early-stage triple negative breast cancer. Cancer Sci 106(11):1582\u20131589","journal-title":"Cancer Sci"},{"issue":"4","key":"157_CR42","doi-asserted-by":"crossref","first-page":"e5344","DOI":"10.1371\/journal.pone.0005344","volume":"4","author":"RR Vallabhajosyula","year":"2009","unstructured":"Vallabhajosyula RR, Chakravarti D, Lutfeali S, Ray A, Raval A, (2009) Identifying Hubs in Protein Interaction Networks. PLoS ONE 4(4):e5344","journal-title":"PLoS ONE"},{"key":"157_CR37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.onc.1206122","volume":"22","author":"D Wei","year":"2003","unstructured":"Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K (2003) Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22:319\u2013329","journal-title":"Oncogene"},{"key":"157_CR38","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1038\/sj.onc.1203972","volume":"19","author":"D Yu","year":"2000","unstructured":"Yu D, Hung M-C (2000) Overexpression of ErbB2 in cancer and ErbB2-targeting strategies. Oncogene 19:6115\u20136121","journal-title":"Oncogene"},{"issue":"4","key":"157_CR40","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1371\/journal.pcbi.0030059","volume":"3","author":"H Yu","year":"2007","unstructured":"Yu H, Kim PM, Sprecher E, Trifinov V, Gerstein M (2007) The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics. PLoS Comput Biol 3(4):e59","journal-title":"PLoS Comput Biol"},{"key":"157_CR41","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3892\/ijmm.2014.2057","volume":"35","author":"D-Y Zhuang","year":"2015","unstructured":"Zhuang D-Y, Jiang L, He Q-Q, Zhou P, Yue T (2015) Identification of hub subnetwork based on topological features of genes in breast cancer. Int J Mol Med 35:664\u2013674","journal-title":"Int J Mol Med"}],"container-title":["Network Modeling Analysis in Health Informatics and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13721-017-0157-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-017-0157-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-017-0157-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T02:08:17Z","timestamp":1512439697000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13721-017-0157-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,15]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["157"],"URL":"https:\/\/doi.org\/10.1007\/s13721-017-0157-6","relation":{},"ISSN":["2192-6662","2192-6670"],"issn-type":[{"value":"2192-6662","type":"print"},{"value":"2192-6670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,15]]},"article-number":"17"}}