{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T23:41:53Z","timestamp":1705534913759},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Netw Model Anal Health Inform Bioinforma"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s13721-019-0208-2","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T18:51:29Z","timestamp":1575312689000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deciphering the function of unknown Leishmania donovani cytosolic proteins using hyperparameter-tuned random forest"],"prefix":"10.1007","volume":"9","author":[{"given":"Pradeep","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awanish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"208_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nrd2381","volume":"6","author":"RP Araujo","year":"2007","unstructured":"Araujo RP et al (2007) Proteins, drug targets and the mechanisms they control: the simple truth about complex networks. Nat Rev Drug Discov 6:871\u2013880","journal-title":"Nat Rev Drug Discov"},{"key":"208_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1010933404324","volume":"45","author":"L Breiman","year":"2001","unstructured":"Breiman L (2001) Random forests. Mach Learn 45:5\u201332","journal-title":"Mach Learn"},{"key":"208_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s13721-016-0127-4","volume":"5","author":"K Dhusia","year":"2016","unstructured":"Dhusia K, Kesarwani P, Yadav PK (2016) Epitope prediction for msp119 protein in Plasmodium yeolii using computational approaches. Netw Model Anal Health Inform Bioinform (Springer) 5:19","journal-title":"Netw Model Anal Health Inform Bioinform (Springer)"},{"issue":"10","key":"208_CR4","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1093\/bioinformatics\/btx005","volume":"33","author":"Q Hou","year":"2017","unstructured":"Hou Q et al (2017) Seeing the trees through the forest: sequence-based homo-and heteromeric protein-protein interaction sites prediction using random forest. Bioinformatics 33(10):1479\u20131487","journal-title":"Bioinformatics"},{"key":"208_CR5","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1109\/TMI.2015.2512606","volume":"35","author":"C Jin","year":"2016","unstructured":"Jin C et al (2016) 3D fast automatic segmentation of kidney based on modified AAM and random forest. IEEE Trans Med Imaging 35:1395\u20131407","journal-title":"IEEE Trans Med Imaging"},{"key":"208_CR6","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.actatropica.2009.10.006","volume":"113","author":"A Kumar","year":"2010","unstructured":"Kumar A et al (2010) Amplified fragment length polymorphism (AFLP) analysis is useful for distinguishing Leishmania species of visceral and cutaneous forms. Acta Trop 113:202\u2013206","journal-title":"Acta Trop"},{"key":"208_CR7","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/2049-632X.12103","volume":"70","author":"A Kumar","year":"2014","unstructured":"Kumar A et al (2014) Mass spectrometry-based proteomic analysis of Leishmania donovani soluble proteins in Indian clinical isolate. Pathog Dis 70:84\u201387","journal-title":"Pathog Dis"},{"key":"208_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.parint.2015.01.004","volume":"64","author":"A Kumar","year":"2015","unstructured":"Kumar A et al (2015) Proteomic analyses of membrane enriched proteins of Leishmania donovani Indian clinical isolate by mass spectrometry. Parasitol Int 64:36\u201342","journal-title":"Parasitol Int"},{"key":"208_CR9","doi-asserted-by":"publisher","first-page":"5700","DOI":"10.1016\/j.vaccine.2008.08.021","volume":"26","author":"S Kumari","year":"2008","unstructured":"Kumari S et al (2008) Th1-stimulatory polyproteins of soluble Leishmania donovani promastigotes ranging from 89.9 to 97.1\u00a0kDa offers long-lasting protection against experimental visceral leishmaniasis. Vaccine 26:5700\u20135711","journal-title":"Vaccine"},{"key":"208_CR10","unstructured":"Landis JR, Koch GG (2008) The measurement of observer agreement for categorical data. Biometrics 33(1):159\u2013174"},{"key":"208_CR11","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1099\/jmm.0.009290-0","volume":"58","author":"P Misra","year":"2009","unstructured":"Misra P et al (2009) Pro-apoptotic effect of the landrace Bangla Mahoba of Piper betle on Leishmania donovani may be due to the high content of eugenol. J Med Microbiol 58:1058\u20131066","journal-title":"J Med Microbiol"},{"key":"208_CR12","unstructured":"Pal SK, Pal A (2001) Pattern recognition: from classical to modern approaches. World Scientific, pp 1\u2013612"},{"key":"208_CR13","first-page":"725","volume":"5","author":"JR Quinlan","year":"2006","unstructured":"Quinlan JR (2006) Bagging, boosting, and C4.5. Proc Thirteen Natl Conf Artif Intell 5:725\u2013730","journal-title":"Proc Thirteen Natl Conf Artif Intell"},{"key":"208_CR14","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1093\/bioinformatics\/btw765","volume":"33","author":"R Rahman","year":"2017","unstructured":"Rahman R et al (2017) IntegratedMRF: random forest-based framework for integrating prediction from different data types. Bioinformatics 33:1407\u20131410","journal-title":"Bioinformatics"},{"key":"208_CR15","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1109\/TCBB.2016.2570217","volume":"14","author":"AK Sinha","year":"2017","unstructured":"Sinha AK et al (2017) Putative drug and vaccine target identification in Leishmania donovani membrane proteins using naive bayes probabilistic classifier. IEEE Trans Comput Biol Bioinforma 14:204\u2013211","journal-title":"IEEE Trans Comput Biol Bioinforma"},{"key":"208_CR16","unstructured":"Steinwart I, Christmann A (2008) Support vector machines. Information Science and Statistics. Springer, pp 1\u2013601"},{"issue":"6","key":"208_CR17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/nbt825","volume":"21","author":"A Vazquez","year":"2003","unstructured":"Vazquez A et al (2003) Global protein function prediction from protein\u2014protein interaction networks. Nat Biotechnol 21(6):697\u2013700","journal-title":"Nat Biotechnol"},{"key":"208_CR18","first-page":"1","volume-title":"Data mining: practical machine learning tools and techniques","author":"I Witten","year":"2011","unstructured":"Witten I et al (2011) Data mining: practical machine learning tools and techniques, 3rd edn. Elsevier, Amsterdam, pp 1\u2013664","edition":"3"}],"container-title":["Network Modeling Analysis in Health Informatics and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-019-0208-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13721-019-0208-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-019-0208-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:16:43Z","timestamp":1695482203000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13721-019-0208-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["208"],"URL":"https:\/\/doi.org\/10.1007\/s13721-019-0208-2","relation":{},"ISSN":["2192-6662","2192-6670"],"issn-type":[{"value":"2192-6662","type":"print"},{"value":"2192-6670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,2]]},"assertion":[{"value":"1 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author declares that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"2"}}