{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T03:37:19Z","timestamp":1779075439475,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Netw Model Anal Health Inform Bioinforma"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s13721-021-00312-8","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T20:02:42Z","timestamp":1623355362000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Molecular docking and dynamics studies of curcumin with COVID-19 proteins"],"prefix":"10.1007","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4088-5785","authenticated-orcid":false,"given":"Renuka","family":"Suravajhala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Parashar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gourav","family":"Choudhir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5023-7618","authenticated-orcid":false,"given":"Anuj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babita","family":"Malik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viswanathan Arun","family":"Nagaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govindarajan","family":"Padmanaban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rathnagiri","family":"Polavarapu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-278X","authenticated-orcid":false,"given":"Prashanth","family":"Suravajhala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. B. Kavi","family":"Kishor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"issue":"9","key":"312_CR1","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1002\/jcc.21773","volume":"32","author":"MJ Abraham","year":"2011","unstructured":"Abraham MJ, Gready JF (2011) Optimization of parameters for molecular dynamics simulations using smooth particle mesh Ewald in GROMACS 4.5. J Comput Chem 32(9):2031\u20132040. https:\/\/doi.org\/10.1002\/jcc.21773","journal-title":"J Comput Chem"},{"key":"312_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ddr.21762","volume":"2020","author":"F Babaei","year":"2020","unstructured":"Babaei F, Mirzababaei M, Nassiri-Asl M, Hosseinzadeh H (2020) Review of registered clinical trials for the treatment of COVID-19. Drug Develop Res 2020:1\u201320. https:\/\/doi.org\/10.1002\/ddr.21762","journal-title":"Drug Develop Res"},{"key":"312_CR3","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1002\/pro.2279","volume":"22","author":"N Balasco","year":"2013","unstructured":"Balasco N, Esposito L, De Simone AD, Vitagliano L (2013) Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms. Protein Sci 22:1016\u20131023. https:\/\/doi.org\/10.1002\/pro.2279","journal-title":"Protein Sci"},{"issue":"29","key":"312_CR4","doi-asserted-by":"publisher","first-page":"8722","DOI":"10.1021\/jp302103t","volume":"116","author":"NC Benson","year":"2012","unstructured":"Benson NC, Daggett V (2012) A comparison of multiscale methods for the analysis of molecular dynamics simulations. J Phys Chem B 116(29):8722\u20138731. https:\/\/doi.org\/10.1021\/jp302103t","journal-title":"J Phys Chem B"},{"key":"312_CR5","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1063\/1.448118","volume":"81","author":"HJ Berendsen","year":"1984","unstructured":"Berendsen HJ, Postma JV, van Gunsteren WF, DiNola A, Haak JR (1984) Molecular dynamics with coupling to an external bath. J Chem Phys 81:3684\u20133690. https:\/\/doi.org\/10.1063\/1.448118","journal-title":"J Chem Phys"},{"key":"312_CR6","doi-asserted-by":"publisher","first-page":"8801","DOI":"10.1128\/jvi.77.16.8801-8811.2003","volume":"77","author":"BJ Bosch","year":"2003","unstructured":"Bosch BJ, van der Zee R, de Haan CA, Rottier PJ (2003) The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex. J Virol 77:8801\u20138811. https:\/\/doi.org\/10.1128\/jvi.77.16.8801-8811.2003","journal-title":"J Virol"},{"issue":"37","key":"312_CR200","doi-asserted-by":"publisher","first-page":"25783","DOI":"10.1074\/jbc.M114.577353","volume":"289","author":"M Bouvet","year":"2014","unstructured":"Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert BI et al (2014) \u201cCoronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.\u201d J Biol Chem 289(37):25783\u201325796. https:\/\/doi.org\/10.1074\/jbc.M114.577353","journal-title":"J Biol Chem"},{"key":"312_CR7","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/jmv.25681","volume":"92","author":"Y Chen","year":"2020","unstructured":"Chen Y, Liu Q, Guo D (2020) Emerging coronaviruses: Genome structure, replication, and pathogenesis. J Medical Virol 92:418\u2013423. https:\/\/doi.org\/10.1002\/jmv.25681","journal-title":"J Medical Virol"},{"key":"312_CR8","doi-asserted-by":"publisher","first-page":"e1002294","DOI":"10.1371\/journal.ppat.1002294","volume":"7","author":"Y Chen","year":"2011","unstructured":"Chen Y, Su C, Ke M, Jin X, Xu L, Zhang Z et al (2011) (2011) Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2\u2032-O-methylation by nsp16\/nsp10 protein complex. PLoS Pathol 7:e1002294. https:\/\/doi.org\/10.1371\/journal.ppat.1002294","journal-title":"PLoS Pathol"},{"key":"312_CR9","unstructured":"CORINA\/MN-AM website: https:\/\/www.mn-am.com\/"},{"key":"312_CR10","volume-title":"The PyMOL molecular graphics system","author":"WL DeLano","year":"2002","unstructured":"DeLano WL (2002) The PyMOL molecular graphics system. Delano Scientific, San Carlos"},{"issue":"6","key":"312_CR11","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.pharep.2018.05.008","volume":"70","author":"S Dolati","year":"2018","unstructured":"Dolati S, Ahmadi M, Aghebti-Maleki L (2018) Nanocurcumin is a potential novel therapy for multiple sclerosis by influencing inflammatory mediators. Pharmacol Rep 70(6):1158\u20131167. https:\/\/doi.org\/10.1016\/j.pharep.2018.05.008","journal-title":"Pharmacol Rep"},{"issue":"10","key":"312_CR12","doi-asserted-by":"publisher","first-page":"7898","DOI":"10.1002\/jcb.26829","volume":"119","author":"A Hesari","year":"2018","unstructured":"Hesari A, Ghasemi F, Salarinia R, Biglari H, Tabar Molla Hassan A, Abdoli V, Mirzaei H (2018) Effects of curcumin on NF-\u03baB, AP-1, and Wnt\/\u03b2-catenin signaling pathway in hepatitis B virus infection. J Cell Biochem 119(10):7898\u20137904. https:\/\/doi.org\/10.1002\/jcb.26829","journal-title":"J Cell Biochem"},{"issue":"1","key":"312_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1021\/ct700200b","volume":"4","author":"B Hess","year":"2008","unstructured":"Hess B (2008) P-LINCS: a parallel linear constraint solver for molecular simulation. J Chem Theory Comput 4(1):116\u2013122. https:\/\/doi.org\/10.1021\/ct700200b","journal-title":"J Chem Theory Comput"},{"issue":"12","key":"312_CR14","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","volume":"18","author":"B Hess","year":"1997","unstructured":"Hess B, Bekker H, Berendsen HJ, Fraaije JG (1997) LINCS: a linear constraint solver for molecular simulations. J Comput Chem 18(12):1463\u20131472","journal-title":"J Comput Chem"},{"issue":"18","key":"312_CR15","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1111\/febs.12936","volume":"281","author":"R Hilgenfeld","year":"2014","unstructured":"Hilgenfeld R (2014) From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design. FEBS J 281(18):4085\u20134096. https:\/\/doi.org\/10.1111\/febs.12936","journal-title":"FEBS J"},{"issue":"20","key":"312_CR16","doi-asserted-by":"publisher","first-page":"30229","DOI":"10.1016\/j.cell.2020.02.052","volume":"S0092\u20138674","author":"M Hoffmann","year":"2020","unstructured":"Hoffmann M, Kleine-Weber H, Schroeder S, Kr\u00fcger N, Herrler T, Erichsen S (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell S0092\u20138674(20):30229\u201330234. https:\/\/doi.org\/10.1016\/j.cell.2020.02.052","journal-title":"Cell"},{"issue":"7","key":"312_CR17","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1016\/j.apsb.2020.04.009","volume":"10","author":"S Kang","year":"2020","unstructured":"Kang S et al (2020) Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharm Sin B 10(7):1228\u20131238. https:\/\/doi.org\/10.1016\/j.apsb.2020.04.009","journal-title":"Acta Pharm Sin B"},{"issue":"7","key":"312_CR18","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1021\/ci500020m","volume":"54","author":"R Kumari","year":"2014","unstructured":"Kumari R, Kumar R, Consortium OSDD, Lynn A (2014) gmmpbsa a GROMACS tool for high throughput MM-PBSA calculations. J Chem Inform Mod 54(7):1951\u20131962. https:\/\/doi.org\/10.1021\/ci500020m","journal-title":"J Chem Inform Mod"},{"key":"312_CR19","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3389\/fcell.2020.00479","volume":"8","author":"Z Liu","year":"2020","unstructured":"Liu Z, Ying Y (2020) The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia. Front Cell Develop Biol 8:479. https:\/\/doi.org\/10.3389\/fcell.2020.00479","journal-title":"Front Cell Develop Biol"},{"issue":"3","key":"312_CR20","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s12291-020-00902-9","volume":"35","author":"Y Manoharan","year":"2020","unstructured":"Manoharan Y, Haridas V, Vasanthakumar KC, Muthu S, Thavoorullah FF, Shetty P (2020) Curcumin: a wonder drug as a preventive measure for COVID19 management. Ind J Clinical Biochem 35(3):373\u2013375","journal-title":"Ind J Clinical Biochem"},{"issue":"8","key":"312_CR21","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.3390\/v6082991","volume":"6","author":"R McBride","year":"2014","unstructured":"McBride R, van Zyl M, Fielding BC (2014) The coronavirus nucleocapsid is a multifunctional protein. Viruses 6(8):2991\u20133018. https:\/\/doi.org\/10.3390\/v6082991","journal-title":"Viruses"},{"key":"312_CR22","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris GM et al (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30:2785\u20132791. https:\/\/doi.org\/10.1002\/jcc.21256","journal-title":"J Comput Chem"},{"issue":"5","key":"312_CR23","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","volume":"60","author":"KM Nelson","year":"2017","unstructured":"Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA (2017) The essential medicinal chemistry of curcumin: mini-perspective. J Med Chem 60(5):1620\u20131637. https:\/\/doi.org\/10.1021\/acs.jmedchem.6b00975","journal-title":"J Med Chem"},{"key":"312_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"NM O'Boyle","year":"2011","unstructured":"O\u2019Boyle NM, BanckM JCA, Morley C, Vandermeersch T, Hutchison GR (2011) Open babel: an open chemical toolbox. J Cheminf 3:33. https:\/\/doi.org\/10.1186\/1758-2946-3-33","journal-title":"J Cheminf"},{"key":"312_CR25","doi-asserted-by":"publisher","first-page":"105044","DOI":"10.1016\/j.worlddev.2020.105044","volume":"134","author":"JA Oldekop","year":"2020","unstructured":"Oldekop JA, Horner R, Hulme D, Adhikari R, Agarwal B, Alford M, Bakewell O, Banks N, Barrientos S, Bastia T, Bebbington AJ (2020) COVID-19 and the case for global development. World Dev 134:105044","journal-title":"World Dev"},{"issue":"13","key":"312_CR26","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera\u2014a visualization system for exploratory research and analysis. J Comput Chem 25(13):1605\u20131612","journal-title":"J Comput Chem"},{"key":"312_CR28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/B978-0-444-64057-4.00006-5","volume":"57","author":"G Padmanaban","year":"2018","unstructured":"Padmanaban G, Nagaraj VA (2018) Curcumin from turmeric as adjunct drug. Studies Nat Products Chem 57:179\u2013292","journal-title":"Studies Nat Products Chem"},{"key":"312_CR29","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1021\/acsmedchemlett.7b00051","volume":"8","author":"G Padmanaban","year":"2017","unstructured":"Padmanaban G, Nagaraj VA (2017) Curcumin may defy medicinal chemists. ACS Med Chem Lett 8:274. https:\/\/doi.org\/10.1021\/acsmedchemlett.7b00051","journal-title":"ACS Med Chem Lett"},{"key":"312_CR30","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","volume":"46","author":"S Prasad","year":"2014","unstructured":"Prasad S, Tyagi AK, Aggarwal BB (2014) Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat off J Korean Cancer Assoc 46:2\u201318. https:\/\/doi.org\/10.4143\/crt.2014.46.1.2","journal-title":"Cancer Res Treat off J Korean Cancer Assoc"},{"key":"312_CR31","doi-asserted-by":"publisher","first-page":"e57278","DOI":"10.7554\/eLife.57278","volume":"9","author":"GP Rossi","year":"2020","unstructured":"Rossi GP, Sanga V, Barton M (2020) Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients. Elife 9:e57278. https:\/\/doi.org\/10.7554\/eLife.57278","journal-title":"Elife"},{"issue":"7","key":"312_CR32","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.18520\/cs\/v118\/i7\/1087-1092","volume":"118","author":"MH Sampangi-Ramaiah","year":"2020","unstructured":"Sampangi-Ramaiah MH, Vishwakarma R, Shaanker RU (2020) Molecular docking analysis of selected natural products from plants for inhibition of SARS-CoV-2 main protease. Current Sci 118(7):1087\u20131092","journal-title":"Current Sci"},{"issue":"8","key":"312_CR33","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1107\/S0907444904011679","volume":"60","author":"AW Sch\u00fcttelkopf","year":"2004","unstructured":"Sch\u00fcttelkopf AW, Van Aalten DM (2004) PRODRG: a tool for high-throughputcrystallography of protein-ligand complexes. Acta Crystallo Sect D Biol Crystallo 60(8):1355\u20131363. https:\/\/doi.org\/10.1107\/S0907444904011679","journal-title":"Acta Crystallo Sect D Biol Crystallo"},{"key":"312_CR34","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1002\/ptr.6054","volume":"32","author":"V Soleimani","year":"2018","unstructured":"Soleimani V, Sahebkar A, Hosseinzadeh H (2018) Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res 32:985\u2013995. https:\/\/doi.org\/10.1002\/ptr.6054","journal-title":"Phytother Res"},{"issue":"16","key":"312_CR35","doi-asserted-by":"publisher","first-page":"7902","DOI":"10.1128\/JVI.00483-06","volume":"80","author":"D Su","year":"2006","unstructured":"Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z (2006) Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. J Virol 80(16):7902\u20137908. https:\/\/doi.org\/10.1128\/JVI.00483-06","journal-title":"J Virol"},{"issue":"16","key":"312_CR36","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/jcc.20291","volume":"26","author":"D Van Der Spoel","year":"2005","unstructured":"Van Der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE, Berendsen HJ (2005) GROMACS: fast, flexible, and free. J Comp Chem 26(16):1701\u20131718. https:\/\/doi.org\/10.1002\/jcc.20291","journal-title":"J Comp Chem"},{"key":"312_CR37","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","volume":"181","author":"AC Walls","year":"2020","unstructured":"Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D (2020) Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell 181:281-292.e6. https:\/\/doi.org\/10.1016\/j.cell.2020.02.058","journal-title":"Cell"},{"issue":"2","key":"312_CR38","doi-asserted-by":"publisher","first-page":"11157","DOI":"10.1073\/pnas.1708727114","volume":"114","author":"AC Walls","year":"2017","unstructured":"Walls AC, Tortorici MA, Snijder J, Xiong X, Bosch BJ, Rey FA, Veesler D (2017) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Proc Nat Acad Sci 114(2):11157\u201311162. https:\/\/doi.org\/10.1073\/pnas.1708727114","journal-title":"Proc Nat Acad Sci"},{"issue":"1","key":"312_CR39","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.3892\/mmr.2017.8085","volume":"17","author":"M Xia","year":"2018","unstructured":"Xia M, Ye Z, Shi Y, Zhou L, Hua Y (2018) Curcumin improves diabetes mellitus-associated cerebral infarction by increasing the expression of GLUT1 and GLUT3. Mol Med Rep 17(1):1963\u20131969. https:\/\/doi.org\/10.3892\/mmr.2017.8085","journal-title":"Mol Med Rep"},{"issue":"10","key":"312_CR40","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.3390\/molecules21101401","volume":"21","author":"M Yang","year":"2016","unstructured":"Yang M, Lee G, Si J, Lee SJ, You HJ, Ko G (2016) Curcumin shows antiviral properties against norovirus. Molecules 21(10):1401. https:\/\/doi.org\/10.3390\/molecules21101401","journal-title":"Molecules"},{"issue":"11","key":"312_CR41","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1002\/ptr.6738","volume":"34","author":"F Zahedipour","year":"2020","unstructured":"Zahedipour F, Hosseini SA, Sathyapalan T, Majeed M, Jamialahmadi T, Al-Rasadi K, Banach M, Sahebkar A (2020) Potential effects of curcumin in the treatment of COVID-19 infection. Phytother Res 34(11):2911\u20132920. https:\/\/doi.org\/10.1002\/ptr.6738","journal-title":"Phytother Res"},{"issue":"14","key":"312_CR42","doi-asserted-by":"publisher","first-page":"6962","DOI":"10.1128\/JVI.00133-08","volume":"82","author":"B Zhou","year":"2008","unstructured":"Zhou B, Liu J, Wang Q, Liu X, Li X, Li P, Ma Q, Cao C (2008) The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha. J Virol 82(14):6962\u20136971. https:\/\/doi.org\/10.1128\/JVI.00133-08","journal-title":"J Virol"}],"container-title":["Network Modeling Analysis in Health Informatics and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-021-00312-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13721-021-00312-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-021-00312-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T08:37:56Z","timestamp":1639039076000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13721-021-00312-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,10]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["312"],"URL":"https:\/\/doi.org\/10.1007\/s13721-021-00312-8","relation":{},"ISSN":["2192-6662","2192-6670"],"issn-type":[{"value":"2192-6662","type":"print"},{"value":"2192-6670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,10]]},"assertion":[{"value":"1 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationship that could be constructed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"44"}}