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To strengthen these efforts, the \u201cCOVID Moonshot\u201d project has been accepting public suggestions for computationally triaged, synthesized, and tested molecules. The project aimed to identify molecules of low molecular weight with activity against the virus, for oral treatment. The ability of a drug to cross the intestinal cell membranes and enter circulation decisively influences its bioavailability, and hence the need to optimize permeability in the early stages of drug discovery. In our present work, as a contribution to the ongoing scientific efforts, we employed artificial neural network algorithms to develop QSAR tools for modelling the PAMPA effective permeability (passive diffusion) of orally administered drugs. We identified a set of 61 features most relevant in explaining drug cell permeability and used them to develop a stacked regression ensemble model, subsequently used to predict the permeability of molecules included in datasets made available through the COVID Moonshot project. Our model was shown to be robust and may provide a promising framework for predicting the potential permeability of molecules not yet synthesized, thus guiding the process of drug design.<\/jats:p>","DOI":"10.1007\/s13721-023-00410-9","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T14:02:45Z","timestamp":1675692165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of artificial neural network models to predict the PAMPA effective permeability of new, orally administered drugs active against the coronavirus SARS-CoV-2"],"prefix":"10.1007","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7093-3055","authenticated-orcid":false,"given":"Chrysoula","family":"Gousiadou","sequence":"first","affiliation":[]},{"given":"Philip","family":"Doganis","sequence":"additional","affiliation":[]},{"given":"Haralambos","family":"Sarimveis","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"unstructured":"https:\/\/github.com\/postera-ai\/COVID_moonshot_submissions","key":"410_CR1"},{"key":"410_CR2","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1039\/C1MD00093D","volume":"2","author":"A Alex","year":"2011","unstructured":"Alex A, Millan DS, Perez M et al (2011) Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space. 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