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This will help patients to receive in time diagnosis and prevention. Conventionally, physicians provide cardiac diagnoses by visual examination of electrocardiograms (ECGs). However, this can be a very time consuming and demanding task and, in some cases, may lead to overlooking and wrong diagnosis of life-threatening heart diseases. Therefore, an intelligent model can help to automatically analyze these huge amount of ECGs captured by different devices in clinical practice. A deep transfer learning approach is used to utilize the capability of different trained deep neural networks and to test them on new unseen datasets without the need to fully re-train the model. Two deep neural networks, namely, Visual Geometry Group (VGG) and Residual Network (ResNet) are utilized for classification of ECGs heartbeats. The models are evaluated using two unseen ECG datasets (i.e., SVDB and INCARTDB) by only optimizing their last classification layers. The overall area under curve for receiver operating characteristic (AUCROC) of two VGG and ResNet models are 0.961 and 0.966 on the SVDB dataset, respectively, and both models achieve 0.981 on the INCARTDB. This paper proposes an accurate and explainable model to classify ECG heartbeats into five categories recommended by the ANSI\/AAMI standard. The proposed method paves the way to use pre-trained deep neural networks in real-time monitoring of heart patients using ECG data and to help clinicians understand the decision made by the models on each case using an explainable approach.\n<\/jats:p>","DOI":"10.1007\/s13721-024-00481-2","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T22:45:29Z","timestamp":1724453129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["xECG-Beats: an explainable deep transfer learning approach for ECG-based heartbeat classification"],"prefix":"10.1007","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-9442","authenticated-orcid":false,"given":"Abdolrahman","family":"Peimankar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uffe Kock","family":"Wiil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"481_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2022.119483","volume":"216","author":"MM Ahsan","year":"2023","unstructured":"Ahsan MM, Uddin MR, Ali MS, Islam MK, Farjana M, Sakib AN, Al Momin K, Luna SA (2023) Deep transfer learning approaches for monkeypox disease diagnosis. 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