{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:43:16Z","timestamp":1773196996080,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["No. 2022YFC3601601"],"award-info":[{"award-number":["No. 2022YFC3601601"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["No. 2022YFC3601603"],"award-info":[{"award-number":["No. 2022YFC3601603"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["No. 2021YFC2009400"],"award-info":[{"award-number":["No. 2021YFC2009400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Three Major Construction Projects of Sun Yat-sen University-Forward Cultivation Project for National Key Research and Development Program of China","award":["No. 82000-18843404"],"award-info":[{"award-number":["No. 82000-18843404"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 61876194"],"award-info":[{"award-number":["No. 61876194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 11661007"],"award-info":[{"award-number":["No. 11661007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Key Research and Development Program of Guangdong Province","doi-asserted-by":"crossref","award":["No. 2018B010109006"],"award-info":[{"award-number":["No. 2018B010109006"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Special Project of Guangdong Province","award":["No. 202011020004"],"award-info":[{"award-number":["No. 202011020004"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["No. 2021A1515011897"],"award-info":[{"award-number":["No. 2021A1515011897"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Guangzhou","award":["No. 202206010028"],"award-info":[{"award-number":["No. 202206010028"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Health Inf Sci Syst"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In order to meet restrictions and difficulties in the development of hospital medical informatization and clinical databases in China, in this study, a disease-specific clinical database system (DSCDS) was designed and built. It provides support for the full utilization of real world medical big data in clinical research and medical services for specific diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The development of DSCDS involved (1) requirements analysis on precision medicine, medical big data, and clinical research; (2) design schematics and basic architecture; (3) standard datasets of specific diseases consisting of common data elements (CDEs); (4) collection and aggregation of specific disease data scattered in various medical business systems of the hospital; (5) governance and quality improvement of specific disease data; (6) data storage and computing; and (7) design of data application modules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A DSCDS for liver cirrhosis was created in the gastrointestinal department of a 3A grade hospital in China and had more than nine data application modules. Based on this DSCDS, a series of clinical studies are being carried out, such as retrospective or prospective cohorts, prognostic studies using multimodal data, and follow-up studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The development of the DSCDS for liver cirrhosis in this paper provides experience and reference for the design and development of DSCDSs for other specific diseases in China; it can even expand to the development of DSCDSs in other countries if they have the demand for DSCDS and the same or better medical informatization foundation. DSCDS has more accurate, standard, comprehensive, multimodal and usable data of specific diseases than the general clinical database system and clinical data repository (CDR) and provides a credible data foundation for medical research, clinical decision-making and improving the medical service quality of specific diseases.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13755-023-00211-4","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T17:02:37Z","timestamp":1675098157000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Design and development of a disease-specific clinical database system to increase the availability of hospital data in China"],"prefix":"10.1007","volume":"11","author":[{"given":"Mimi","family":"Liu","sequence":"first","affiliation":[]},{"given":"Jinni","family":"Luo","sequence":"additional","affiliation":[]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[]},{"given":"Xuemei","family":"Pan","sequence":"additional","affiliation":[]},{"given":"Shuyan","family":"Tan","sequence":"additional","affiliation":[]},{"given":"Weidong","family":"Ji","sequence":"additional","affiliation":[]},{"given":"Hongzheng","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Shengsheng","family":"Tang","sequence":"additional","affiliation":[]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Zebin","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Xiaoying","family":"Wu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-2234","authenticated-orcid":false,"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"issue":"20","key":"211_CR1","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.3760\/cma.j.issn.0366-6999.20130857","volume":"126","author":"T Wu","year":"2013","unstructured":"Wu T, Li P, Xu J, Zhou B, Xu WG. Enterprise service bus and standard based hospital integration platform and its application research. Chin Med J. 2013;126(20):3978\u201381.","journal-title":"Chin Med J"},{"issue":"01","key":"211_CR2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13020-021-00437-y","volume":"16","author":"DT Li","year":"2021","unstructured":"Li DT, Liang HY, Liu GJ. Discussion on data standardization in the construction of clinical research database. China Digit Med. 2021;16(01):29\u201334.","journal-title":"China Digit Med"},{"key":"211_CR3","doi-asserted-by":"crossref","first-page":"205520762211121","DOI":"10.1177\/20552076221112152","volume":"8","author":"P Wang","year":"2022","unstructured":"Wang P, Li T, Yu L, Zhou L, Yan T. Towards an effective framework for integrating patient-reported outcomes in electronic health records. Digit Health. 2022;8:20552076221112150.","journal-title":"Digit Health"},{"issue":"1","key":"211_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10840-016-0104-y","volume":"47","author":"C Austin","year":"2016","unstructured":"Austin C, Kusumoto F. The application of Big Data in medicine: current implications and future directions. J Interv Card Electrophysiol. 2016;47(1):51\u20139.","journal-title":"J Interv Card Electrophysiol"},{"issue":"1","key":"211_CR5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s13755-022-00183-x","volume":"10","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Sheng M, Liu X, Wang R, Lin W, Ren P, Wang X, Zhao E, Song W. A heterogeneous multi-modal medical data fusion framework supporting hybrid data exploration. Health Inf Sci Syst. 2022;10(1):22.","journal-title":"Health Inf Sci Syst"},{"key":"211_CR6","first-page":"211","volume":"1","author":"C Weng","year":"2016","unstructured":"Weng C, Kahn MG. Clinical research informatics for big data and precision medicine. Yearb Med Inform. 2016;1:211\u20138.","journal-title":"Yearb Med Inform"},{"issue":"13","key":"211_CR7","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1056\/NEJMp1606181","volume":"375","author":"Z Obermeyer","year":"2016","unstructured":"Obermeyer Z, Emanuel EJ. Predicting the future-big data, machine learning, and clinical medicine. N Engl J Med. 2016;375(13):1216\u20139.","journal-title":"N Engl J Med"},{"issue":"2","key":"211_CR8","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1109\/TBME.2016.2573285","volume":"64","author":"PY Wu","year":"2017","unstructured":"Wu PY, Cheng CW, Kaddi CD, Venugopalan J, Hoffman R, Wang MD. Omic and electronic health record big data analytics for precision medicine. IEEE Trans Biomed Eng. 2017;64(2):263\u201373.","journal-title":"IEEE Trans Biomed Eng"},{"issue":"4","key":"211_CR9","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1109\/JBHI.2015.2406883","volume":"19","author":"M Viceconti","year":"2015","unstructured":"Viceconti M, Hunter P, Hose R. Big data, big knowledge: big data for personalized healthcare. IEEE J Biomed Health Inform. 2015;19(4):1209\u201315.","journal-title":"IEEE J Biomed Health Inform"},{"issue":"4","key":"211_CR10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.semradonc.2019.05.002","volume":"29","author":"CJ Tsai","year":"2019","unstructured":"Tsai CJ, Riaz N, Gomez SL. Big data in cancer research: real-world resources for precision oncology to improve cancer care delivery. Semin Radiat Oncol. 2019;29(4):306\u201310.","journal-title":"Semin Radiat Oncol"},{"issue":"6","key":"211_CR11","doi-asserted-by":"publisher","first-page":"543","DOI":"10.2217\/pme-2018-0035","volume":"15","author":"LJ Frey","year":"2018","unstructured":"Frey LJ. Data integration strategies for predictive analytics in precision medicine. Per Med. 2018;15(6):543\u201351.","journal-title":"Per Med"},{"issue":"1","key":"211_CR12","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s13755-021-00151-x","volume":"9","author":"AB Menegotto","year":"2021","unstructured":"Menegotto AB, Becker CDL, Cazella SC. Computer-aided diagnosis of hepatocellular carcinoma fusing imaging and structured health data. Health Inf Sci Syst. 2021;9(1):20.","journal-title":"Health Inf Sci Syst"},{"issue":"1","key":"211_CR13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1177\/0300891618792473","volume":"105","author":"N Maggi","year":"2019","unstructured":"Maggi N, Gazzarata R, Ruggiero C, Lombardo C, Giacomini M. Cancer precision medicine today: towards omic information in healthcare systems. Tumori. 2019;105(1):38\u201346.","journal-title":"Tumori"},{"issue":"3","key":"211_CR14","doi-asserted-by":"publisher","first-page":"20170030","DOI":"10.1515\/jib-2017-0030","volume":"15","author":"B Ristevski","year":"2018","unstructured":"Ristevski B, Chen M. Big data analytics in medicine and healthcare. J Integr Bioinform. 2018;15(3):20170030.","journal-title":"J Integr Bioinform"},{"key":"211_CR15","first-page":"100","volume":"227","author":"L Min","year":"2016","unstructured":"Min L, Liu J, Lu X, Duan H, Qiao Q. An implementation of clinical data repository with openEHR approach: from data modeling to architecture. Stud Health Technol Inform. 2016;227:100\u20135.","journal-title":"Stud Health Technol Inform"},{"issue":"7","key":"211_CR16","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1093\/jamia\/ocy020","volume":"25","author":"L Wang","year":"2018","unstructured":"Wang L, Zhang Y, Jiang M, Wang J, Dong J, Liu Y, Tao C, Jiang G, Zhou Y, Xu H. Toward a normalized clinical drug knowledge base in China-applying the RxNorm model to Chinese clinical drugs. J Am Med Inform Assoc. 2018;25(7):809\u201318.","journal-title":"J Am Med Inform Assoc"},{"key":"211_CR17","doi-asserted-by":"publisher","first-page":"103418","DOI":"10.1016\/j.jbi.2020.103418","volume":"105","author":"Q Wang","year":"2020","unstructured":"Wang Q, Ji Z, Wang J, Wu S, Lin W, Li W, Ke L, Xiao G, Jiang Q, Xu H, Zhou Y. A study of entity-linking methods for normalizing Chinese diagnosis and procedure terms to ICD codes. J Biomed Inform. 2020;105:103418.","journal-title":"J Biomed Inform"},{"issue":"Suppl 1","key":"211_CR18","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1186\/s12859-021-04236-y","volume":"22","author":"Y Xiong","year":"2021","unstructured":"Xiong Y, Chen S, Tang B, Chen Q, Wang X, Yan J, Zhou Y. Improving deep learning method for biomedical named entity recognition by using entity definition information. BMC Bioinform. 2021;22(Suppl 1):600.","journal-title":"BMC Bioinform"},{"key":"211_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109377","volume":"233","author":"KK Abassa","year":"2022","unstructured":"Abassa KK, Xiao XP, Zhou HX, Wu XY, Guo YW, Wu B. FcGBP and VCAM-1 are ponderable biomarkers for differential diagnosis of alcoholic liver cirrhosis. Drug Alcohol Depend. 2022;233: 109377.","journal-title":"Drug Alcohol Depend"},{"issue":"1","key":"211_CR20","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12876-022-02198-w","volume":"22","author":"KK Abassa","year":"2022","unstructured":"Abassa KK, Wu XY, Xiao XP, Zhou HX, Guo YW, Wu B. Effect of alcohol on clinical complications of hepatitis virus-induced liver cirrhosis: a consecutive ten-year study. BMC Gastroenterol. 2022;22(1):130.","journal-title":"BMC Gastroenterol"},{"issue":"7","key":"211_CR21","doi-asserted-by":"publisher","first-page":"540","DOI":"10.21037\/atm-20-3401","volume":"9","author":"X Wang","year":"2021","unstructured":"Wang X, Luo J, Liu C, Liu Y, Wu X, Zheng F, Wen Z, Tian H, Wei X, Guo Y, Li J, Chen X, Tao J, Qi X, Wu B. Impact of variceal eradication on rebleeding and prognosis in cirrhotic patients undergoing secondary prophylaxis. Ann Transl Med. 2021;9(7):540.","journal-title":"Ann Transl Med"},{"key":"211_CR22","doi-asserted-by":"crossref","first-page":"205520762211095","DOI":"10.1177\/20552076221109554","volume":"8","author":"P Nielsen","year":"2022","unstructured":"Nielsen P, Sahay S. A critical review of the role of technology and context in digital health research. Digit Health. 2022;8:20552076221109550.","journal-title":"Digit Health"}],"container-title":["Health Information Science and Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13755-023-00211-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13755-023-00211-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13755-023-00211-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T08:28:01Z","timestamp":1728808081000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13755-023-00211-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["211"],"URL":"https:\/\/doi.org\/10.1007\/s13755-023-00211-4","relation":{},"ISSN":["2047-2501"],"issn-type":[{"value":"2047-2501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"assertion":[{"value":"20 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study designed and developed a disease-specific clinical database system that strictly ensured the data security and privacy protection of patients using many technologies. No individual patient\u2019s data are disclosed within this manuscript in any form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"11"}}