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Biol."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Modeling gene regulatory networks (GRNs) is an important topic in systems biology. Although there has been much work focusing on various specific systems, the generic behavior of GRNs with continuous variables is still elusive. In particular, it is not clear typically how attractors partition among the three types of orbits: steady state, periodic and chaotic, and how the dynamical properties change with network's topological characteristics. In this work, we first investigated these questions in random GRNs with different network sizes, connectivity, fraction of inhibitory links and transcription regulation rules. Then we searched for the core motifs that govern the dynamic behavior of large GRNs. We show that the stability of a random GRN is typically governed by a few embedding motifs of small sizes, and therefore can in general be understood in the context of these short motifs. Our results provide insights for the study and design of genetic networks.<\/jats:p>","DOI":"10.1007\/s40484-014-0026-6","type":"journal-article","created":{"date-parts":[[2014,1,26]],"date-time":"2014-01-26T23:44:19Z","timestamp":1390779859000},"page":"253-260","source":"Crossref","is-referenced-by-count":17,"title":["Generic properties of random gene regulatory networks"],"prefix":"10.1002","volume":"1","author":[{"given":"Zhiyuan","family":"Li","sequence":"first","affiliation":[{"name":"<!--1--> Center for Quantitative Biology School of Physics and Peking\u2010Tsinghua Center for Life Sciences Peking University Beijing 100871 China"},{"name":"<!--2--> Department of Bioengineering and Therapeutic Sciences University of California San Francisco CA 94158 USA"}]},{"given":"Simone","family":"Bianco","sequence":"additional","affiliation":[{"name":"<!--2--> Department of Bioengineering and Therapeutic Sciences University of California San Francisco CA 94158 USA"}]},{"given":"Zhaoyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"<!--3--> Department of Physics Beijing Normal University Beijing 100875 China"}]},{"given":"Chao","family":"Tang","sequence":"additional","affiliation":[{"name":"<!--1--> Center for Quantitative Biology School of Physics and Peking\u2010Tsinghua Center for Life Sciences Peking University Beijing 100871 China"}]}],"member":"311","published-online":{"date-parts":[[2013,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2036429100"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.08.023"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystems.2005.09.010"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.093008.131241"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156951"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305937101"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20105193(69)90015\u20100"},{"key":"e_1_2_7_9_2","article-title":"Boolean dynamics with random couplings","author":"Kadanoff L.","year":"2002","journal-title":"Nlin"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506771102"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165\u20101684(02)00479\u20106"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20102836(85)90086\u20105"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0930314100"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105193(03)00035\u20103"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physd.2006.05.009"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.06.013"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100111"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039355"},{"key":"e_1_2_7_19_2","doi-asserted-by":"crossref","unstructured":"Ehud Kaplan J. 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