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Biol."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Functional genomics employs dozens of OMICs technologies to explore the functions of DNA, RNA and protein regulators in gene regulation processes. Despite each of these technologies being powerful tools on their own, like the parable of blind men and an elephant, any one single technology has a limited ability to depict the complex regulatory system. Integrative OMICS approaches have emerged and become an important area in biology and medicine. It provides a precise and effective way to study gene regulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This article reviews current popular OMICs technologies, OMICs data integration strategies, and bioinformatics tools used for multi\u2010dimensional data integration. We highlight the advantages of these methods, particularly in elucidating molecular basis of biological regulatory mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To better understand the complexity of biological processes, we need powerful bioinformatics tools to integrate these OMICs data. Integrating multi\u2010dimensional OMICs data will generate novel insights into system\u2010level gene regulations and serves as a foundation for further hypothesis\u2010driven research.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s40484-016-0085-y","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T00:47:27Z","timestamp":1479516447000},"page":"283-301","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Applications of integrative OMICs approaches to gene regulation studies"],"prefix":"10.1002","volume":"4","author":[{"given":"Jing","family":"Qin","sequence":"first","affiliation":[{"name":"<!--1--> School of Life Sciences The Chinese University of Hong Kong Hong Kong SAR 999077 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[{"name":"<!--2--> Laboratory for Food Safety and Environmental Technology Institutes of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China"},{"name":"<!--3--> School of Biomedical Sciences The University of Hong Kong Hong Kong SAR 999077 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaohua","family":"Hu","sequence":"additional","affiliation":[{"name":"<!--4--> College of Mathematics and Statistics Shenzhen University Shenzhen 518060 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panwen","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--5--> Department of Health Sciences Research and Center for Individualized Medicine Mayo Clinic Scottsdale AZ 85259 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwen","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--5--> Department of Health Sciences Research and Center for Individualized Medicine Mayo Clinic Scottsdale AZ 85259 USA"},{"name":"<!--6--> Department of Biomedical Informatics Arizona State University Scottsdale AZ 85259 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002130"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2013.12"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/415141a"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/340245a0"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3607"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3454"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2010.12.001"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168978"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3679"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2015.32"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2943"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12598"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2013.06.003"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1736"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061034498"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1218595"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2641"},{"key":"e_1_2_8_19_2","volume-title":"Current Protocols In Molecular Biology, Chapter 21, Unit 21\u201324","author":"Rhee H. 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