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Increasing lines of evidence suggest that back\u2010splicing is catalyzed by the canonical spliceosomal machinery and modulated by <jats:italic>cis<\/jats:italic>\u2010elements and <jats:italic>trans<\/jats:italic>\u2010factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this mini\u2010review, we discuss our current understanding of circRNA biogenesis regulation, mainly focusing on the complex regulation of complementary sequences, especially <jats:italic>Alu<\/jats:italic>s in human, on circRNA formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Back\u2010splicing can be significantly facilitated by RNA pair formed by orientation\u2010opposite complementary sequences that juxtapose flanking introns of circularized exon(s). RNA pair formed within individual introns competes with RNA pair formed across flanking introns in the same gene locus, leading to distinct choices for either canonical splicing or back\u2010splicing. Multiple RNA pairs that bracket different circle\u2010forming exons compete for alternative back\u2010splicing selection, resulting in multiple circRNAs generated in a single gene locus.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s40484-017-0112-7","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T03:06:48Z","timestamp":1501211208000},"page":"205-209","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifaceted roles of complementary sequences on circRNA formation"],"prefix":"10.1002","volume":"5","author":[{"given":"Qin","family":"Yang","sequence":"first","affiliation":[{"name":"<!--1--> CAS Key Laboratory of Computational Biology Collaborative Innovation Center of Genetics and Development CAS\u2010MPG Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai 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