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Biol."],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Next\u2010generation sequencing (NGS) technologies have fostered an unprecedented proliferation of high\u2010throughput sequencing projects and a concomitant development of novel algorithms for the assembly of short reads. However, numerous technical or computational challenges in <jats:italic>de novo<\/jats:italic> assembly still remain, although many new ideas and solutions have been suggested to tackle the challenges in both experimental and computational settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this review, we first briefly introduce some of the major challenges faced by NGS sequence assembly. Then, we analyze the characteristics of various sequencing platforms and their impact on assembly results. After that, we classify <jats:italic>de novo<\/jats:italic> assemblers according to their frameworks (overlap graph\u2010based, <jats:italic>de Bruijn<\/jats:italic> graph\u2010based and string graph\u2010based), and introduce the characteristics of each assembly tool and their adaptation scene. Next, we introduce in detail the solutions to the main challenges of <jats:italic>de novo<\/jats:italic> assembly of next generation sequencing data, single\u2010cell sequencing data and single molecule sequencing data. At last, we discuss the application of SMS long reads in solving problems encountered in NGS assembly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review not only gives an overview of the latest methods and developments in assembly algorithms, but also provides guidelines to determine the optimal assembly algorithm for a given input sequencing data type.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s40484-019-0166-9","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T05:51:42Z","timestamp":1556171502000},"page":"90-109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Current challenges and solutions of <i><b>de novo<\/b><\/i> assembly"],"prefix":"10.1002","volume":"7","author":[{"given":"Xingyu","family":"Liao","sequence":"first","affiliation":[{"name":"<!--1--> School of Computer Science and Engineering Central south University Changsha 410083 China"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"<!--1--> School of Computer Science and Engineering Central south University Changsha 410083 China"}]},{"given":"You","family":"Zou","sequence":"additional","affiliation":[{"name":"<!--1--> School of Computer Science and Engineering Central south University Changsha 410083 China"}]},{"given":"Fang\u2010Xiang","family":"Wu","sequence":"additional","affiliation":[{"name":"<!--2--> Division of Biomedical Engineering University of Saskatchewan Saskatchewan S7N 5A9 Canada"}]},{"family":"Yi\u2010Pan","sequence":"additional","affiliation":[{"name":"<!--3--> Department of Computer Science Georgia State University Atlanta GA 30302 USA"}]},{"given":"Jianxin","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--1--> School of Computer Science and Engineering Central south University Changsha 410083 China"}]}],"member":"311","published-online":{"date-parts":[[2019,6]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2010.03.001"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3367"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003998"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2144\/000114133"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbs015"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102010\u201011\u201011\u2010r116"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.11.014"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010015\u20101519\u2010z"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3642"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1966"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006864"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2018.2861380"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03959"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089670"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2640"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.191395.115"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep31602"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.089532.108"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017351108"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.126953.111"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/2047\u2010217X\u20101\u201018"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102012\u201013\u20104\u2010243"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.1995.2.291"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2023"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.072033.107"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2196"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.828403"},{"key":"e_1_2_9_29_2","first-page":"23","article-title":"The present and future of de novo whole\u2010genome assembly.","volume":"19","author":"Sohn J. 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