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In the past, germline pathogenic variants have been thought to have only minor\u2010heritable contributions to cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Emerging evidence has shown that germline genomes play a dominant\u2010heritable contribution to cancer via encoding the host immune system. The functional components of the immune system are encoded by the host genome, thus the germline genome might have a profound impact on cancer immune evasion and immunotherapy response. Indeed, recent studies showed that germline pathogenic variants can influence immune capacity in cancer patients at a population level by (i) shaping tumor somatic mutations, altering methylation patterns and antigen\u2010presentation capacity or (ii) influencing NK cell\u2019s function to modulate lymphocyte infiltration in the tumor microenvironment. In addition, the HLA (types A, B or C) genotypes also shape the landscape of tumor somatic mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results highlight the indispensable roles of germline genome in immunity and cancer development and suggest that germline genomics should be integrated into the research field of cancer biology and cancer immunotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s40484-020-0212-7","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T15:04:02Z","timestamp":1596207842000},"page":"216-227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Germline genomes have a dominant\u2010heritable contribution to cancer immune evasion and immunotherapy response"],"prefix":"10.1002","volume":"8","author":[{"given":"Xue","family":"Jiang","sequence":"first","affiliation":[{"name":"<!--1--> Shanghai Mental Health Center School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Asad","sequence":"additional","affiliation":[{"name":"<!--2--> Department of Biochemistry and Molecular Biology Cumming School of Medicine University of Calgary Calgary T2N 4N1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"<!--2--> Department of Biochemistry and Molecular Biology Cumming School of Medicine University of Calgary Calgary T2N 4N1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanpeng","family":"Sun","sequence":"additional","affiliation":[{"name":"<!--2--> Department of Biochemistry and Molecular Biology Cumming School of Medicine University of Calgary Calgary T2N 4N1 Canada"},{"name":"<!--3--> Tianjin Normal University Tianjin 300074 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010S\u00e9bastien","family":"Milanese","sequence":"additional","affiliation":[{"name":"<!--4--> Human Health Therapeutics Research Centre National Research Council Canada Montreal H4P 2R2 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liao","sequence":"additional","affiliation":[{"name":"<!--5--> School of Mathematics and Statistics Hainan Normal University Haikou 570206 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--2--> Department of Biochemistry and Molecular Biology Cumming School of Medicine University of Calgary Calgary T2N 4N1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900475"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201018\u20100940"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5229"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201015\u20101125"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201018\u20101942"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.03.008"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.2535"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00453"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.012"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100014\u2010x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.314617.118"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010018\u20100191\u20101"},{"key":"e_1_2_6_15_2","first-page":"1013","article-title":"Population genetics of BRCA1 and BRCA2.","volume":"60","author":"Szabo C. 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