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Biol."],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Phase transition and phase separation as well as their tipping points are penetrating phenomena in biology and are intrinsic properties of biological systems ranging from basic molecule complexes to cells and all way up to entire ecosystems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For example, phase separation has been established as a key mechanism for biological molecules such as protein or RNA to form membraneless organelles to perform complex biological functions. Phase transitions are commonly observed during cellular differentiation, and generally, there are the tipping points or critical states just before the phase transitions. And the stability of ecosystem and extinction of species are systematic manifestation of phase transitions. All phase transition and phase separation phenomena display switch\u2010like behavior and critical transitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Here we summarize the concepts regarding the epithelial\u2010to\u2010mesenchymal transition (EMT) as a type of phase changes and the implication of critical transitions in EMT, and discuss open questions and challenges in this fast\u2010moving field.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s40484-020-0219-0","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T08:05:41Z","timestamp":1599811541000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Critical transitions and tipping points in EMT"],"prefix":"10.1002","volume":"8","author":[{"given":"Peng","family":"Wang","sequence":"first","affiliation":[{"name":"<!--1--> Key Laboratory of Computational Biology CAS\u2010MPG Partner Institute for Computational Biology Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China"},{"name":"<!--4--> School of Life Science and Technology ShanghaiTech University Shanghai 201210 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luonan","family":"Chen","sequence":"additional","affiliation":[{"name":"<!--2--> Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai 200031 China"},{"name":"<!--3--> Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming 650223 China"},{"name":"<!--4--> School of Life Science and Technology ShanghaiTech University Shanghai 201210 China"},{"name":"<!--5--> Institute of Brain\u2010Intelligence Technology Zhangjiang Laboratory Shanghai 201210 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_11_2_2","unstructured":"Stanley H. 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