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Performing this task manually is a cumbersome, expensive, and time-consuming process for hematologists, and therefore computer-aided systems have been developed to help with this problem. This paper proposes an improved method of classification of WBCs utilizing a combination of preprocessing, convolutional neural networks (CNNs), feature selection algorithms, and classifiers. In preprocessing, contrast-limited adaptive histogram equalization (CLAHE) is applied to the input images. A CNN is designed and trained to be used for feature extraction along with ResNet50 and EfficientNetB0 networks. Ant colony optimization is used to select the best features which are then serially fused and passed onto classifiers such as support vector machine (SVM) and quadratic discriminant analysis (QDA) for classification. The classification accuracy achieved on the Blood Cell Images dataset is 98.44%, which shows the robustness of the proposed work.<\/jats:p>","DOI":"10.1007\/s40747-021-00564-x","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T15:02:57Z","timestamp":1634914977000},"page":"3143-3159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Categorizing white blood cells by utilizing deep features of proposed 4B-AdditionNet-based CNN network with ant colony optimization"],"prefix":"10.1007","volume":"8","author":[{"given":"Asim","family":"Shahzad","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-9298","authenticated-orcid":false,"given":"Mudassar","family":"Raza","sequence":"additional","affiliation":[]},{"given":"Jamal Hussain","family":"Shah","sequence":"additional","affiliation":[]},{"given":"Muhammad","family":"Sharif","sequence":"additional","affiliation":[]},{"given":"Ramesh Sunder","family":"Nayak","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"564_CR1","unstructured":"How Much Blood Is in the Human Body? https:\/\/www.healthline.com\/health\/how-much-blood-in-human-body. 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