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In this article we review the lessons learned from COVID-19 to postulate possible solutions for a Disease X event. The overall purpose of the study and the research problems investigated is the integration of artificial intelligence\u00a0function in digital healthcare systems. The basic design of the study includes a systematic state-of-the-art review, followed by an evaluation of different approaches to managing global pandemics. The study design then engages with constructing a new methodology for integrating algorithms in healthcare systems, followed by analysis of the new methodology and a discussion. Action research is applied to review existing state of the art, and a qualitative case study method is used to analyse the knowledge acquired from the COVID-19 pandemic. Major trends found as a result of the study derive from the synthesis of COVID-19 knowledge, presenting new insights in the form of a conceptual methodology\u2014that includes six phases for managing a future Disease X event, resulting with a summary map of various problems, solutions and expected results from integrating functional AI in healthcare systems.<\/jats:p>","DOI":"10.1007\/s43681-021-00111-x","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T12:24:24Z","timestamp":1634646264000},"page":"623-630","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Methodology for integrating artificial intelligence in healthcare systems: learning from COVID-19 to prepare for Disease X"],"prefix":"10.1007","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-6857","authenticated-orcid":false,"given":"Petar","family":"Radanliev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"De Roure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Maple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchenna","family":"Ani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"111_CR1","doi-asserted-by":"publisher","first-page":"102248","DOI":"10.1016\/j.cose.2021.102248","volume":"105","author":"HS Lallie","year":"2021","unstructured":"Lallie, H.S., Shepherd, L.A., Nurse, J.R.C., Erola, A., Epiphaniou, G., Maple, C., Bellekens, X.: Cyber security in the age of COVID-19: A timeline and analysis of cyber-crime and cyber-attacks during the pandemic. 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