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The possibilities for day-to-day clinical practice opened up by AI-driven clinical decision support systems (AI-CDSS) give rise to fundamental questions around responsibility. In causal, moral and legal terms the application of AI-CDSS is challenging existing attributions of responsibility. In this context, responsibility gaps are often identified as main problem. Mapping out the changing dynamics and levels of attributing responsibility, we argue in this article that the application of AI-CDSS causes diffusions of responsibility with respect to a causal, moral, and legal dimension. Responsibility diffusion describes the situation where multiple options and several agents can be considered for attributing responsibility. Using the example of an AI-driven \u2018digital tumor board\u2019, we\u00a0illustrate\u00a0how clinical decision-making is changed and diffusions of responsibility take place. Not denying or attempting to bridge responsibility gaps, we argue that dynamics and ambivalences are inherent in responsibility, which is based on normative considerations such as avoiding experiences of disregard and vulnerability of human life, which are inherently accompanied by a moment of uncertainty, and is characterized by revision openness. Against this background and to avoid responsibility gaps, the article concludes with suggestions for managing responsibility diffusions in clinical decision-making with AI-CDSS.<\/jats:p>","DOI":"10.1007\/s43681-022-00135-x","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T14:02:49Z","timestamp":1643032969000},"page":"747-761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Diffused responsibility: attributions of responsibility in the use of AI-driven clinical decision support systems"],"prefix":"10.1007","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-4901","authenticated-orcid":false,"given":"Hannah","family":"Bleher","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-6027","authenticated-orcid":false,"given":"Matthias","family":"Braun","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"135_CR1","unstructured":"European Commission: Communication from the Commission to the European Parliament, the European Council, the Council, the European Economic and Social Committee and the Committee of the Regions on Artificial Intelligence for Europe, Brussels, COM (2018) 237 final., Apr 2018. 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