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Advances in AI hold the promise of improving the precision of outcome prediction at the level of the individual. However, the addition of these technologies to patient\u2013clinician interactions, as with any complex human interaction, has potential pitfalls. While physicians have always had to carefully consider the ethical background and implications of their actions, detailed deliberations around fast-moving technological progress may not have kept up. We use a common but key challenge in healthcare interactions, the disclosure of bad news (likely imminent death), to illustrate how the philosophical framework of the 'Felicific Calculus' developed in the eighteenth century by Jeremy Bentham, may have a timely quasi-quantitative application in the age of AI. We show how this ethical algorithm can be used to assess, across seven mutually exclusive and exhaustive domains, whether an AI-supported action can be morally justified.<\/jats:p>","DOI":"10.1007\/s43681-022-00230-z","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T13:18:01Z","timestamp":1667222281000},"page":"1215-1228","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Breaking bad news in the era of artificial intelligence and algorithmic medicine: an exploration of disclosure and its ethical justification using the hedonic calculus"],"prefix":"10.1007","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-0827","authenticated-orcid":false,"given":"Benjamin","family":"Post","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9808-2475","authenticated-orcid":false,"given":"Cosmin","family":"Badea","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-7207","authenticated-orcid":false,"given":"Aldo","family":"Faisal","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-8413","authenticated-orcid":false,"given":"Stephen J.","family":"Brett","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"issue":"11","key":"230_CR1","doi-asserted-by":"publisher","first-page":"e1008453","DOI":"10.1371\/journal.pcbi.1008453","volume":"16","author":"M Kulmanov","year":"2020","unstructured":"Kulmanov, M., Hoehndorf, R.: DeepPheno: predicting single gene loss-of-function phenotypes using an ontology-aware hierarchical classifier. 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