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This information is currently under-used for health research and innovation. Free text requires more processing for analysis than structured data, but processing natural language at scale has recently advanced, using large language models. However, data controllers are often concerned about patient privacy risks if clinical text is allowed to be used in research. Text can be de-identified, yet it is challenging to quantify the residual risk of patient re-identification. This paper presents a comprehensive review and discussion of elements for consideration when evaluating the risk of patient re-identification from free text. We consider (1) the reasons researchers want access to free text; (2) the accuracy of automated de-identification processes, identifying best practice; (3) methods previously used for re-identifying health data and their success; (4) additional protections put in place around health data, particularly focussing on the UK where \u201cFive Safes\u201d secure data environments are used; (5) risks of harm to patients from potential re-identification and (6) public views on free text being used for research. We present a model to conceptualise and evaluate risk of re-identification, accompanied by case studies of successful governance of free text for research in the UK. When de-identified and stored in secure data environments, the risk of patient re-identification from clinical free text is very low. More health research should be enabled by routinely storing and giving access to de-identified clinical text data.<\/jats:p>","DOI":"10.1007\/s43681-025-00681-0","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T15:07:05Z","timestamp":1740582425000},"page":"4441-4454","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["What is the patient re-identification risk from using de-identified clinical free text data for health research?"],"prefix":"10.1007","volume":"5","author":[{"given":"Elizabeth","family":"Ford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Pillinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerina","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlene","family":"Casey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Nenadic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"3","key":"681_CR1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/ije\/dyv098","volume":"44","author":"E Herrett","year":"2015","unstructured":"Herrett, E., Gallagher, A.M., Bhaskaran, K., Forbes, H., Mathur, R., van Staa, T., Smeeth, L.: Data resource profile: clinical practice research datalink (CPRD). 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