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Traditional centralized employment matching systems face privacy constraints, data sovereignty requirements, and limited collaborative learning capabilities. This paper presents a comprehensive privacy-preserving federated learning framework for multi-regional disability employment matching that enables collaborative model training while maintaining data locality and regulatory compliance. Our approach combines ensemble-based LightGBM federation with parameter-level MLP federation, achieving 0.9011 F1-score (LightGBM) and 0.7881 F1-score (MLP with privacy preservation) across five Italian employment centers in Veneto region. The privacy framework integrates differential privacy with RDP composition (\u03b5\u2009=\u20091.0, \u03b4\u2009=\u200910\u207b\u2076), Shamir\u2019s 3-of-5 secret sharing for secure aggregation, and blockchain anchoring for long-term integrity verification. Empirical evaluation demonstrates minimal performance degradation under federated constraints (0.0005 F1-score loss) while providing formal privacy guarantees. The system reduces manual processing time from 30\u201360\u00a0min to under 5\u00a0min per candidate with sub-100\u00a0ms response times suitable for real-world deployment. Ongoing pilot deployment at partner employment centers validates practical applicability for European disability employment services. The research contributes to trustworthy AI frameworks for sensitive social applications requiring regulatory compliance, algorithmic fairness, and privacy preservation.<\/jats:p>","DOI":"10.1007\/s44163-026-01014-8","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:36:52Z","timestamp":1772026612000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Privacy-preserving federated learning for multi-regional disability employment matching: a comprehensive framework with differential privacy and blockchain anchoring"],"prefix":"10.1007","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-6326","authenticated-orcid":false,"given":"Oleksandr","family":"Kuznetsov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6332-0435","authenticated-orcid":false,"given":"Michele","family":"Melchiori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-6424","authenticated-orcid":false,"given":"Alessandro","family":"Galdelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-9244","authenticated-orcid":false,"given":"Emanuele","family":"Frontoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-3075","authenticated-orcid":false,"given":"Marco","family":"Arnesano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"1014_CR1","volume-title":"Report on the Employment of Disabled People in European Countries: Italy","author":"A Micangeli","year":"2008","unstructured":"Micangeli A, Puglisi A, Vignola R. 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All synthetic data generation procedures were designed to prevent potential harm to individuals with disabilities. The federated learning framework preserves data locality and individual privacy while enabling collaborative improvement of employment services.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing financial or non-financial interests related to this research. The author Alessandro Galdelli is a member of the Editorial board of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"281"}}