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Further research is needed to effectively integrate ontologies into collaborative filtering recommender systems. This paper proposes an ontology-based semantic similarity measure to evaluate similarities between items and eventually generate accurate recommendations. The proposed semantic similarity measure termed fusion-based semantic similarity takes into account the semantics of ontological instances (i.e. items) inferred from a specific domain ontology, which is determined by analyzing the hierarchical relationships among the instances, as well as the features of the instances and their relationships to other instances. The new measure comprehensively captures the semantic knowledge associated with instances by exploiting all possible shared semantics between instances in a given domain ontology. Furthermore, this paper proposes a new semantic-enhanced hybrid recommendation approach as a result of combining the new semantic similarity measure with the standard item-based CF to enhance the quality of generated recommendations. In order to assess the effectiveness of our semantic-enhanced hybrid collaborative filtering method, a series of experiments were conducted to compare the performance of the proposed approach against well-established benchmark techniques. The reported experimental results consistently emphasize its superiority, demonstrating enhanced predictive abilities and a notable improvement in the quality of recommendations. More specifically, the proposed approach achieved notable 6% reduction in Mean Absolute Error (MAE) in certain cases, outperforming other benchmark techniques. Additionally, this study highlights the potential of using semantic-based similarity to enhance the performance of recommendation systems. 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