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In this research, we explored the opportunities, challenges, and prospects of PLMs in urban science research. Specifically, we discussed potential applications of PLMs to urban institution, urban space, urban information, and citizen behaviors research through seven examples using ChatGPT. We also examined the challenges of PLMs in urban science research from both technical and social perspectives. The prospects of the application of PLMs in urban science research were then proposed. We found that PLMs can effectively aid in understanding complex concepts in urban science, facilitate urban spatial form identification, assist in disaster monitoring, sense public sentiment and so on. They have expanded the breadth of urban research in terms of content, increased the depth and efficiency of the application of multi-source big data in urban research, and enhanced the interaction between urban research and other disciplines. At the same time, however, the applications of PLMs in urban science research face evident threats, such as technical limitations, security, privacy, and social bias. The development of fundamental models based on domain knowledge and human-AI collaboration may help improve PLMs to support urban science research in future.\n<\/jats:p>","DOI":"10.1007\/s44212-024-00042-y","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T01:01:21Z","timestamp":1714352481000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Towards human-AI collaborative urban science research enabled by pre-trained large language models"],"prefix":"10.1007","volume":"3","author":[{"given":"Jiayi","family":"Fu","sequence":"first","affiliation":[]},{"given":"Haoying","family":"Han","sequence":"additional","affiliation":[]},{"given":"Xing","family":"Su","sequence":"additional","affiliation":[]},{"given":"Chao","family":"Fan","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"42_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cities.2020.102986","volume":"109","author":"M Abdul-Rahman","year":"2021","unstructured":"Abdul-Rahman, M., Chan, E. 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