{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:33:37Z","timestamp":1789418017539,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Metast"],"published-print":{"date-parts":[[1993,3]]},"DOI":"10.1007\/bf00114973","type":"journal-article","created":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T06:58:33Z","timestamp":1099292313000},"page":"151-158","source":"Crossref","is-referenced-by-count":51,"title":["Expression of nucleoside diphosphate kinase\/nm23 gene product in human pancreatic cancer: an association with lymph node metastasis and tumor invasion"],"prefix":"10.1007","volume":"11","author":[{"given":"Shoji","family":"Nakamori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ohhigashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Kameyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Inaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Higashiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingi","family":"Imaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwanaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Funai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narimichi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1002\/1097-0142(19871101)60:9<2284::AID-CNCR2820600930>3.0.CO;2-V","volume":"60","author":"B Gudjonsson","year":"1987","unstructured":"Gudjonsson B, 1987, Cancer of the pancreas, 50 years of surgery. Cancer, 60, 2284?2303.","journal-title":"Cancer"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00000658-198601000-00013","volume":"203","author":"R Tsuchiya","year":"1986","unstructured":"Tsuchiya R, Noda T, Harada N, Miyamoto T, Tomioka T, Yamamoto K, Yamaguchi T, Izawa K, Tsunoda T, Yoshino R and Eto T, 1986, Collective review of small carcinomas of the pancreas. Annals of Surgery, 203, 77?81.","journal-title":"Annals of Surgery"},{"key":"CR3","first-page":"5185","volume":"49","author":"G Bevilacqua","year":"1989","unstructured":"Bevilacqua G, Sobel ME, Liotta LA and Steeg, PS, 1989, Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Research, 49, 5185?5190.","journal-title":"Cancer Research"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/jnci\/83.4.281","volume":"83","author":"C Hennessy","year":"1991","unstructured":"Hennessy C, Henry JA, May FEB, Westley BR, Angus B and Lennard TWJ, 1991, Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis. Journal of the National Cancer Institute, 83, 281?285.","journal-title":"Journal of the National Cancer Institute"},{"key":"CR5","first-page":"245","volume":"139","author":"R Barnes","year":"1991","unstructured":"Barnes R, Masood S, Barker E, Rosengard AM, Coggin DL, Crowell T, King CR, Porter-Jordan K, Wargotz ES, Liotta LA and Steeg PS, 1991, Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. American Journal of Pathology, 139, 245?250.","journal-title":"American Journal of Pathology"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/jnci\/80.3.200","volume":"80","author":"PS Steeg","year":"1988","unstructured":"Steeg PS, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JM, Liotta LA and Sobel ME, 1988, Evidence for a novel gene associated with low tumor metastatic potential. Journal of the National Cancer Institute, 80, 200?204.","journal-title":"Journal of the National Cancer Institute"},{"key":"CR7","first-page":"6550","volume":"48","author":"PS Steeg","year":"1988","unstructured":"Steeg PS, Bevilacqua G, Pozzatti R, Liotta LA and Sobel ME, 1988, Altered expression on nm23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis. Cancer Research, 48, 6550?6554.","journal-title":"Cancer Research"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/342177a0","volume":"342","author":"AM Rosengard","year":"1989","unstructured":"Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IMK, King CR, Liotta LA and Steeg PA, 1989, Reduced nm23\/awd protein in tumor metastasis and aberrant Drosophila development. Nature, 342, 177?180.","journal-title":"Nature"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0092-8674(91)90404-M","volume":"65","author":"A Leone","year":"1991","unstructured":"Leone A, Flatow U, King CR, Sandeen MA, Marugulies IMK, Liotta LA and Steeg PS, 1991, Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell, 65, 25?35.","journal-title":"Cell"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1016\/S0021-9258(18)31515-1","volume":"266","author":"AM Gilles","year":"1991","unstructured":"Gilles AM, Presecan E, Vonica A and Lascu I, 1991, Nucleoside diphosphate kinase from human erythrocytes, structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. Journal of Biological Chemistry, 266, 8784?8789.","journal-title":"Journal of Biological Chemistry"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/jnci\/82.14.1199","volume":"82","author":"V Wallet","year":"1990","unstructured":"Wallet V, Mutzel R, Troll H, Barzu O, Wurster B, Vernon M and Lacombe ML. 1990, Dictyostelium nucleoside diphosphate kinase highly homologous to nm23 and awd proteins involved in mammalian tumour metastasis and Drosophila development. Journal of the National Cancer Institute, 82, 1199?1202.","journal-title":"Journal of the National Cancer Institute"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0092-8674(90)90496-2","volume":"63","author":"J Biggs","year":"1990","unstructured":"Biggs J, Hersperger E, Steeg PS, Liotta LA and Shearn A, 1990, Drosophila gene that is homologous to a mammalian gene associated with tumour metastasis codes for a nucleoside diphosphate kinase. Cell, 63, 933?940.","journal-title":"Cell"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"15744","DOI":"10.1016\/S0021-9258(18)55460-0","volume":"265","author":"N Kimura","year":"1990","unstructured":"Kimura N, Shimada N, Nomura K and Watanabe K, 1990, Isolation and characterization of a cDNA clone encoding rat nucleoside diphosphate kinase. Journal of Biological Chemistry, 265, 15744?15749.","journal-title":"Journal of Biological Chemistry"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/jnci\/83.17.1249","volume":"83","author":"R Hirayama","year":"1991","unstructured":"Hirayama R, Sawai S, Takagi Y, Mishima Y, Kimura N, Shimada N, Esaki Y, Kurashima C, Utsuyama M and Hirokawa K, 1991, Positive relationship between expression of anti-metastatic factor (nm23 gene product or nucleoside diphosphate kinase) and good prognosis in human breast cancer. Journal of the National Cancer Institute, 83, 1249?1250.","journal-title":"Journal of the National Cancer Institute"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00000658-198808000-00014","volume":"208","author":"O Ishikawa","year":"1988","unstructured":"Ishikawa O, Ohhigashi H, Sasaki Y, Kabuto T, Fukuda I, Furukawa H, Imaoka S and Iwanaga T, 1988, Practical usefulness of lymphatic and connective tissue clearance for the carcinoma of the pancreas head. Annals of Surgery, 208, 215?220.","journal-title":"Annals of Surgery"},{"key":"CR16","volume-title":"TNM Classification of Malignant Tumors","author":"International Union Against Cancer","year":"1987","unstructured":"International Union Against Cancer. TNM Classification of Malignant Tumors, 4th edn. Berlin: Springer-Verlag, 1987.","edition":"4th edn."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1016\/S0021-9258(18)68831-3","volume":"263","author":"N Kimura","year":"1988","unstructured":"Kimura N and Shimada N, 1988, Membrane-associated nucleoside diphosphate kinase from rat liver: purification, characterization, and comparison with cytosolic enzyme. Journal of Biological Chemistry, 263, 4647?4653.","journal-title":"Journal of Biological Chemistry"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3109\/02841868909092254","volume":"28","author":"PK Lehtinen","year":"1989","unstructured":"Lehtinen PK, Huovinen R and Touminen J, 1989, Pancreatic cancer: evolution of prognostic factors and treatment results. Acta Oncologia, 28, 481?484.","journal-title":"Acta Oncologia"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02924228","volume":"7","author":"HA Reber","year":"1990","unstructured":"Reber HA, 1990, Lymph node involvement as a prognostic factor in pancreatic cancer. International Journal of Pancreatology, 7, 125?127.","journal-title":"International Journal of Pancreatology"},{"key":"CR20","first-page":"459","volume":"80","author":"R Tsuchiya","year":"1985","unstructured":"Tsuchiya R, Orita T and Noda T, 1985, Size of tumor and other factors influencing prognosis of carcinoma of the head of pancreas. American Journal of Gastroenterology, 80, 459?462.","journal-title":"American Journal of Gastroenterology"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/1097-0142(19860415)57:8<1576::AID-CNCR2820570823>3.0.CO;2-9","volume":"57","author":"GD Favero","year":"1986","unstructured":"Favero GD, Fabris C, Plebani M, Panucci A, Piccoli A, Perobelli L, Pedrazzoli S, Baccaglini U, Burlina A and Naccarato R, 1986, CA19?9 and carcinoem bryonic antigen in pancreatic cancer diagnosis. Cancer, 57, 1576?1579.","journal-title":"Cancer"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/jnci\/83.10.712","volume":"83","author":"M Haut","year":"1991","unstructured":"Haut M, Steeg PA, Willson JKV and Markowitz SD, 1991, Induction of nm23 gene expression in human colonic neoplasms and equal expression in colon tumors of high and low metastatic potential. Journal of the National Cancer Institute, 83, 712?716.","journal-title":"Journal of the National Cancer Institute"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/mc.2940020310","volume":"2","author":"B Francis","year":"1989","unstructured":"Francis B, Overmeyer J, John W, Marshall E and Haley B, 1989, Prevalence of nucleoside diphosphate kinase autophosphorylation in human colon carcinoma versus normal colon homogenates. Molecular Carcinogenesis, 2, 168?178.","journal-title":"Molecular Carcinogenesis"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI115299","volume":"88","author":"N Hailat","year":"1991","unstructured":"Hailat N, Keim DR, Melhem RF, Zhu XX, Eckerskorn C, Brodeur GM, Reynolds CP, Seeger RC, Lottspeich F, Strahler JR and Hanash SM, 1991, High levels of p19\/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification. Journal of Clinical Investigation, 88, 341?345.","journal-title":"Journal of Clinical Investigation"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/0277-5379(91)90101-I","volume":"27","author":"ML Lacombe","year":"1991","unstructured":"Lacombe ML, Sastre-Garau X, Lascu I, Vonica A, Wallet V, Thiery JP and Vernon M, 1991, Overexpression of nucleoside diphosphate kinase (nm23) in solid tumors. European Journal of Cancer, 27, 1302?1307.","journal-title":"European Journal of Cancer"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/ijc.2910500406","volume":"50","author":"X Sastre-Garau","year":"1992","unstructured":"Sastre-Garau X, Lacombe ML, Jouve M, Veron M and Magdelenat H, 1992, Nucleoside diphosphate kinase\/nm23 expression in breast cancer: lack of correlation with lymph-node metastasis. International Journal of Cancer, 50, 533?538.","journal-title":"International Journal of Cancer"},{"key":"CR27","first-page":"384","volume":"33","author":"L Wang","year":"1992","unstructured":"Wang L, Bukowski R, Church J, Milsom J and Banerjee S, 1992, Mutation in nm23, a putative metastasis suppressor gene in human colorectal cancer. Proceedings of the 83rd Annual Meeting of the American Association for Cancer Research, 33, 384.","journal-title":"Proceedings of the 83rd Annual Meeting of the American Association for Cancer Research"},{"key":"CR28","unstructured":"Parks REL and Agarwal RP. Nucleoside diphosphokinase. In: Boyer PD, ed. The Enzymes, Vol. 8, pp. 307?334. New York: Academic Press."},{"key":"CR29","first-page":"351","volume":"9","author":"PS Steeg","year":"1989","unstructured":"Steeg PS, 1989, Search for metastasis suppressor genes. Invasion Metastasis, 9, 351?359.","journal-title":"Invasion Metastasis"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0304-4165(86)90254-0","volume":"882","author":"K Ohtsuki","year":"1986","unstructured":"Ohtsuki K, Ikeuch T and Yokoyama M, 1986, Characterization of nucleoside-diphosphate kinase-associated guanine nucleotide-binding proteins from Hela S3 cells. Biochimica et Biophysica Acta, 882, 322?330.","journal-title":"Biochimica et Biophysica Acta"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/0006-2952(90)90420-P","volume":"39","author":"AS Otero","year":"1990","unstructured":"Otero AS, 1990, Transphosphorylation and G protein activation. Biochemical Pharmacology, 39, 1399?1404.","journal-title":"Biochemical Pharmacology"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"21536","DOI":"10.1016\/S0021-9258(18)45773-0","volume":"265","author":"S Kikkawa","year":"1990","unstructured":"Kikkawa S, Takahashi K, Takahashi K, Simada N, Ui M, Kimura N and Katada T, 1990, Conversion of GDP into GTP by nucleoside diphosphate kinase on the GTP-binding protein. Journal of Biological Chemistry, 265, 21536?21540.","journal-title":"Journal of Biological Chemistry"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0092-8674(88)90571-5","volume":"53","author":"C Almoquer","year":"1988","unstructured":"Almoquer C, Shibata D, Fornester K, Martin J, Arnhim N and Perusho M, 1988, Most human carcinomas of the exocrin pancreas contain mutant c-K-ras genes. Cell, 53, 549?554.","journal-title":"Cell"},{"key":"CR34","first-page":"4683","volume":"49","author":"JL Bos","year":"1989","unstructured":"Bos JL, 1989, ras Oncogenes in human cancer: a review. Cancer Research, 49, 4683?4689.","journal-title":"Cancer Research"},{"key":"CR35","first-page":"445","volume":"51","author":"JA Stahl","year":"1991","unstructured":"Stahl JA, Leone A, Rosengard A, Porter L, King CR and Steeg PS, 1991 Identification of a second human nm23 gene, nm23H-2. Cancer Research, 51, 445?449.","journal-title":"Cancer Research"}],"container-title":["Clinical &amp; Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00114973.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00114973\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00114973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T21:12:06Z","timestamp":1682802726000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00114973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["BF00114973"],"URL":"https:\/\/doi.org\/10.1007\/bf00114973","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}