{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:45:12Z","timestamp":1772815512952,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[1992,5]]},"DOI":"10.1007\/bf00124257","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T12:06:58Z","timestamp":1099397218000},"page":"237-245","source":"Crossref","is-referenced-by-count":11,"title":["Heterogeneity in the clastogenic response to X-rays in lymphocytes from ataxia-telangiectasia heterozygotes and controls"],"prefix":"10.1007","volume":"3","author":[{"given":"John K.","family":"Wiencke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane W.","family":"Wara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl T.","family":"Kelsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/258427a0","volume":"258","author":"AMR Taylor","year":"1975","unstructured":"Taylor AMR, Harnden OG, Arlett CG, et al. Ataxia-telangiectasia: a human mutation with abnormal radiation sensitivity. Nature (Lond) 1975; 258: 427?9.","journal-title":"Nature"},{"key":"CR2","first-page":"103","volume-title":"Ataxia Telangiectasia: A Cellular and Molecular Link Between Cancer, Neuropathology and Immune Deficiency","author":"BD Spector","year":"1982","unstructured":"Spector BD, Filipovich AH, Perry GSIII, Kersey JH. Epidemiology of cancer in ataxia-telangiectasia. In: Bridges BA, Harnden DG, eds. Ataxia Telangiectasia: A Cellular and Molecular Link Between Cancer, Neuropathology and Immune Deficiency. New York: Wiley, 1982; 103?38."},{"key":"CR3","first-page":"1","volume-title":"Ataxia Telangiectasia: Genetics, Neuropathology and Immunology of a Degenerative Disease of Childhood","author":"E Boder","year":"1985","unstructured":"Boder E. Ataxia telangiectasia: an overview. In: Gatti RA, Swift M, eds. Ataxia Telangiectasia: Genetics, Neuropathology and Immunology of a Degenerative Disease of Childhood. New York: Alan R. Liss, 1985: 1?63."},{"key":"CR4","first-page":"209","volume":"36","author":"M Swift","year":"1976","unstructured":"Swift M, Sholman L, Perry M, Chase C. Malignant neoplasms in the families of patients with ataxia-telangiectasia. Cancer Res 1976; 36: 209?15.","journal-title":"Cancer Res"},{"key":"CR5","first-page":"133","volume-title":"Ataxia Telangiectasia: Genetics, Neuropathology, and Immunology of a Degenerative Disease of Childhood","author":"M Swift","year":"1985","unstructured":"Swift M. Genetics and epidemiology of ataxia-telangiectasis. In: Gatti RA, Swift M, eds. Ataxia Telangiectasia: Genetics, Neuropathology, and Immunology of a Degenerative Disease of Childhood. New York: Alan R. Liss, 1985: 133?46."},{"key":"CR6","first-page":"573","volume":"39","author":"M Swift","year":"1986","unstructured":"Swift M, Morrell D, Cromartie E, Chamberlin AR, Skolnick MH, Bishop DT. The incidence and gene frequency of ataxia-telangiectasia in the United States. Am J Hum Genet 1986; 39: 573?83.","journal-title":"Am J Hum Genet"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1056\/NEJM198705213162101","volume":"316","author":"M Swift","year":"1987","unstructured":"Swift M, Reitnauer PJ, Morrell D, Chase CL. Breast and other cancers in families with ataxia-telangiectasia. N Engl J Med 1987; 316: 1289?94.","journal-title":"N Engl J Med"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1056\/NEJM199112263252602","volume":"325","author":"M Swift","year":"1991","unstructured":"Swift M, Morrell D, Massey RB, Chase CL. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 1991; 325: 1831?6.","journal-title":"N Engl J Med"},{"key":"CR9","first-page":"398","volume":"47","author":"H Nagasawa","year":"1987","unstructured":"Nagasawa H, Kraemer KH, Shiloh Y, Little JB. Detection of ataxia-telangiectasia heterozygous cell lines by post-irradiation cumulative labeling index: measurements with coded samples. Cancer Res 1987; 47: 398?402.","journal-title":"Cancer Res"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2307\/3576305","volume":"101","author":"JB Little","year":"1985","unstructured":"Little JB, Nagasawa H. Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasis fibroblast. Radiat Res 1985; 101: 81?93.","journal-title":"Radiat Res"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0027-5107(89)90103-6","volume":"211","author":"NS Rudolph","year":"1989","unstructured":"Rudolph NS, Nagasawa H, Little JB, Latt SA. Identification of ataxia telangiectasia heterozygotes by flow cytometric analysis of X-ray damage. Mut Res 1989; 211: 19?29.","journal-title":"Mut Res"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/274484a0","volume":"274","author":"PC Chen","year":"1978","unstructured":"Chen PC, Lavin MF, Kidson C, Moss D. Identification of ataxia-telangiectasia heterozygotes?a cancer prone population. Nature (Lond) 1978; 274: 484?6.","journal-title":"Nature"},{"key":"CR13","first-page":"3725","volume":"39","author":"MC Paterson","year":"1979","unstructured":"Paterson MC, Anderson AK, Smith BP, Smith PJ. Enhanced radiosensitivity of cultured fibroblasts from ataxia-telangiectasia heterozygotes manifested by defective colony-forming ability and reduced DNA repair replication after hypoxic X-irradiation. Cancer Res 1979; 39: 3725?34.","journal-title":"Cancer Res"},{"key":"CR14","first-page":"3950","volume":"42","author":"TJ Kinsella","year":"1982","unstructured":"Kinsella TJ, Mitchell JB, McPherson S, Russa A, Tretze F. In vitro X-ray sensitivity in ataxia-telangiectasia homozygote and heterozygote skin fibroblasts under oxic and hypoxic condition. Cancer Res 1982; 42: 3950?6.","journal-title":"Cancer Res"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1080\/09553008814552321","volume":"44","author":"CF Arlett","year":"1988","unstructured":"Arlett CF, Green MHL, Priestley A, Harcourt SA, Mayne LV. Comparative human cellular radiosensitivity. I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes. Int J Radiat Biol 1988; 44: 911?28.","journal-title":"Int J Radiat Biol"},{"key":"CR16","first-page":"101","volume-title":"Ataxia Telangiectasia: Genetics, Neuropathology and Immunology of a Degenerative Disease of Childhood","author":"CF Arlett","year":"1985","unstructured":"Arlett CF, Priestley A. An assessment of the radiosensitivity of ataxia-telangiectasia heterozygotes. In: Gatti RA, Swift M, eds. Ataxia Telangiectasia: Genetics, Neuropathology and Immunology of a Degenerative Disease of Childhood. New York: Alan R. Liss, 1985: 101?9."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2307\/3578071","volume":"128","author":"DE Weeks","year":"1991","unstructured":"Weeks DE, Paterson MC, Lange K, et al. Assessment of chronic radiosensitivity as an in vitro assay for heterozygote identification of ataxia-telangiectasia. Radiat Res 1991; 128: 90?9.","journal-title":"Radiat Res"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/BF00210804","volume":"84","author":"M Waghray","year":"1990","unstructured":"Waghray M, Al-Sedairy S, Ozand PT, Hannan MA. Cytogenetic characterization of ataxia-telangiectasia (A-T) heterozygotes using lymphoblastoid cell lines and chronic x-irradiation. Hum Genet 1990; 84: 532?4.","journal-title":"Hum Genet"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00210663","volume":"84","author":"Y Shiloh","year":"1989","unstructured":"Shiloh Y, Parshad R, Frydman M, et al. G2 chromosomal radiosensitivity in families with ataxia-telangiectasia. Hum Genet 1989; 84: 15?8.","journal-title":"Hum Genet"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0014-4827(82)90040-4","volume":"137","author":"PH Kohn","year":"1982","unstructured":"Kohn PH, Kraemer KH, Buchanan JK. Influence of ataxia-telangiectasia gene dosage on bleomycin-induced chromosome breakage and inhibition of replication in human lymphoblastoid cell lines. Exp Cell Res 1982; 137: 387?95.","journal-title":"Exp Cell Res"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000131739","volume":"33","author":"AT Natarajan","year":"1982","unstructured":"Natarajan AT, Meyers M, vanZealand AA, Simons JWIM. Attempts to detect ataxia-telangiectasia (A-T) heterozygotes by cytogenetical techniques. Cytogenet Cell Genet 1982; 33: 145?51.","journal-title":"Cytogenet Cell Genet"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF00280482","volume":"74","author":"MP Rosin","year":"1986","unstructured":"Rosin MP, Ochs HD. In vivo chromosomal instability in ataxia-telangiectasia homozygotes and heterozygotes. Hum Genet 1986; 74: 335?40.","journal-title":"Hum Genet"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0165-4608(85)90227-4","volume":"14","author":"R Parshad","year":"1985","unstructured":"Parshad R, Sanford KK, Jones GM, Tarone RE. G2 chromosomal radiosensitivity of ataxia-telangiectasia heterozygotes. Cancer Genet Cytogenet 1985; 14: 163?8.","journal-title":"Cancer Genet Cytogenet"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/jnci\/82.12.1050","volume":"82","author":"KK Sanford","year":"1990","unstructured":"Sanford KK, Parshad R, Price FM, et al. Enhanced chromatid damage in blood lymphocytes after G2 phase X-irradiation, a marker of the ataxia-telangiectasia gene. JNCI 1990; 82: 1050?4.","journal-title":"JNCI"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0027-5107(81)90061-0","volume":"84","author":"RB Painter","year":"1981","unstructured":"Painter RB. Radioresistant DNA synthesis: an intrinsic feature of ataxia-telangiectasia. Mutat Res. 1981; 84: 183?90.","journal-title":"Mutat Res."},{"key":"CR26","first-page":"190","volume-title":"Radiation Biochemistry","author":"S Okada","year":"1970","unstructured":"Okada S. Radiation effects on cell progress through the life cycle. In: Altman KI, Gerber GB, Okada S, eds. Radiation Biochemistry. New York: Academic Press, 1970: 190?239."},{"key":"CR27","first-page":"5577","volume":"44","author":"R Parshad","year":"1984","unstructured":"Parshad R, Gantt R, Sanford KK, Jones GM. Chromosomal radiosensitivity of human tumor cells during the G2 cell cycle period,. Cancer Res 1984; 44: 5577?82.","journal-title":"Cancer Res"},{"key":"CR28","first-page":"409","volume":"69","author":"R Parshad","year":"1982","unstructured":"Parshad R, Gantt R, Sanford KK, Jones GM, Tarone RE. Repair of chromosome damage induced by X-irradiation during G2 phase in a line of normal human fibroblasts and its malignant derivative. JNCI 1982; 69: 409?14.","journal-title":"JNCI"},{"key":"CR29","first-page":"2045","volume":"46","author":"K Sanford","year":"1986","unstructured":"Sanford K, Parshad R, Stanbridge EJ, et al. Chromosome radiosensitivity during the G2 cell cycle period and cytopathology of human normal X tumor cell hybrids. Cancer Res 1986; 46: 2045?9.","journal-title":"Cancer Res"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00284606","volume":"52","author":"AT Natarajan","year":"1979","unstructured":"Natarajan AT, Meyers M. Chromosomal radiosensitivity of ataxia-telangiectasia cells at different cell cycle stages. Hum Genet 1979; 52: 127?32.","journal-title":"Hum Genet"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1073\/pnas.82.16.5400","volume":"82","author":"R Parshad","year":"1985","unstructured":"Parshad R, Sanford KK, Jones GM. Chromosomal radiosensitivity during the G2 cell-cycle period of skin fibroblasts from individuals with familial cancer. Proc Natl Acad Sci USA 1985; 82: 5400?3.","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1073\/pnas.80.18.5612","volume":"80","author":"R Parshad","year":"1983","unstructured":"Parshad R, Sanford KK, Jones GM. Chromatid damage after G2 phase X-irradiation of cells from cancer-prone individuals implicates deficiency in DNA repair. Proc Natl Acad Sci USA 1983; 80: 5612?6.","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/0027-5107(79)90115-5","volume":"63","author":"SB Bigelow","year":"1979","unstructured":"Bigelow SB, Rary JM, Bender MA. G2 chromosomal radiosensitivity in Fanconi's anemia. Mutat Res 1979; 63: 1899?99.","journal-title":"Mutat Res"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(87)91546-7","volume":"ii","author":"KK Sanford","year":"1987","unstructured":"Sanford KK, Tarone RE, Parshad R, Tucker MA, Greene MH, Jones GM. Hypersensitivity to G2 chromatid radiation damage in familial dysplastic naevus syndrome. Lancet 1987; ii 1111?6.","journal-title":"Lancet"},{"key":"CR35","first-page":"2579","volume":"48","author":"MA Bender","year":"1988","unstructured":"Bender MA, Viola MV, Fiore J, Thompson MH, Leonard RC. Normal G2 chromosomal radiosensitivity and cell survival in the cancer family syndrome. Cancer Res 1988; 48: 2579?84.","journal-title":"Cancer Res"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0027-5107(85)90044-2","volume":"152","author":"MA Bender","year":"1985","unstructured":"Bender MA, Rary JM, Kale RP. G2 chromosomal radiosensitivity in ataxia-telangiectasia lymphocytes. Mutat Res 1985; 152: 39?47.","journal-title":"Mutat Res"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0027-5107(85)90209-X","volume":"148","author":"H Nagasawa","year":"1985","unstructured":"Nagasawa H, Latt SA, Lalande ME, Little JB. Effects of X-irradiation on cell cycle progression induction of chromosomal aberrations and cell killing in ataxia-telangiectasia (A-T) fibroblasts. Mutat Res 1985; 148: 71?82.","journal-title":"Mutat Res"},{"key":"CR38","first-page":"4535","volume":"48","author":"H Nagasawa","year":"1988","unstructured":"Nagasawa H, Little JB. Radiosensitivities of ten apparently normal human diploid fibroblast strains to cell killing, G2-phase chromosomal aberrations, and cell cycle delay. Cancer Res 1988; 48: 4535?8.","journal-title":"Cancer Res"},{"key":"CR39","first-page":"4626","volume":"49","author":"MR Spitz","year":"1989","unstructured":"Spitz MR, Fueger JJ, Beddingfield NA, et al. Chromosome sensitivity to bleomycin-induced mutagenesis, an independent risk factor for upper aerodigestive tract cancers. Cancer Res 1989; 49: 4626?8.","journal-title":"Cancer Res"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00284040","volume":"82","author":"BR Young","year":"1989","unstructured":"Young BR, Painter RB. Radioresistant DNA synthesis and human genetic diseases. Hum Genet 1989; 82: 113?7.","journal-title":"Hum Genet"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/09553008814552331","volume":"54","author":"J Cole","year":"1988","unstructured":"Cole J, Arlett CF, Green MHL, et al. Comparative human cellular radiosensitivity. II. The survival following gamma-irradiation of unstimulated (G0) T-lymphocytes, T-lymphocyte lines, lymphoblastoid cell lines and fibroblasts from normal donors, from ataxia-telangiectasia patients and from ataxia telangiectasia-heterozygotes. Int J Radiat Biol 1988; 54: 929?43.","journal-title":"Int J Radiat Biol"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00286705","volume":"83","author":"MP Rosin","year":"1989","unstructured":"Rosin MP, Ochs HD, Gatti RA, Boder E. Heterogeneity of chromosomal breakage levels in epithelial tissues of ataxia-telangiectasia homozygotes and heterozygotes. Hum Genet 1989; 83: 133?8.","journal-title":"Hum Genet"},{"key":"CR43","first-page":"402","volume":"44","author":"WL Bigbee","year":"1989","unstructured":"Bigbee WL, Langlois RG, Swift M, Jensen RH. Evidence for an elevated frequency of in vivo somatic cell mutations in ataxia-telangiectasia. Am J Hum Genet 1989; 44: 402?8.","journal-title":"Am J Hum Genet"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2307\/3577662","volume":"123","author":"JB Little","year":"1990","unstructured":"Little JB, Nove J. Sensitivity of human diploid fibroblast cells strains from various genetic disorders to acute and protracted radiation exposure. Radiation Res 1990; 123: 87?92.","journal-title":"Radiation Res"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0027-5107(84)90038-1","volume":"125","author":"MD Ford","year":"1984","unstructured":"Ford MD, Martin L, Lavin MF. The effects of ionizing radiation on cell cycle progression in ataxia-telangiectasia. Mutat Res 1984; 125: 115?22.","journal-title":"Mutat Res"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/336577a0","volume":"336","author":"RA Gatti","year":"1989","unstructured":"Gatti RA, Berkel I, Boder E, et al. Localization of an ataxia-telangiectasia gene to chromosome 11q22?23. Nature 1989; 336: 577?80.","journal-title":"Nature"}],"container-title":["Cancer Causes and Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00124257.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00124257\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00124257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T05:17:34Z","timestamp":1554268654000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00124257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["BF00124257"],"URL":"https:\/\/doi.org\/10.1007\/bf00124257","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}