{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:14:02Z","timestamp":1791137642529,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1991,9,1]],"date-time":"1991-09-01T00:00:00Z","timestamp":683683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Epidemiol"],"published-print":{"date-parts":[[1991,9]]},"DOI":"10.1007\/bf00143140","type":"journal-article","created":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T03:17:42Z","timestamp":1099279062000},"page":"562-566","source":"Crossref","is-referenced-by-count":11,"title":["Transmissible spongiform encephalopathies (TSE) virus-induced amyloidoses of the central nervous system (CNS)"],"prefix":"10.1007","volume":"7","author":[{"given":"H.","family":"Diringer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","unstructured":"Benson M.D. (1981): Hereditary amyloidosis-disease entity and clinical model - Hosp. Pract. (March 15), 165?181"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1002\/j.1460-2075.1985.tb03931.x","volume":"4","author":"H.R. Braig","year":"1985","unstructured":"BraigH.R. and DiringerH. (1985): Scrapie: Concept of a virus-induced amyloidosis of the brain - The EMBO J. 4: 2309?2312.","journal-title":"The EMBO J."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1099\/0022-1317-68-1-79","volume":"68","author":"M.E. Bruce","year":"1987","unstructured":"BruceM.E. and DickinsonA.G. (1987): Biological evidence that scrapie agent has an independant genome - J. Gen. Virol., 68: 79?89.","journal-title":"J. Gen. Virol."},{"key":"CR4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(86)90875-5","volume":"46","author":"G.A. Carlson","year":"1986","unstructured":"CarlsonG.A., KingsburyD.T., GoodmanP., ColemanS., MarshallS.T. et al. (1986): Linkage of prion protein and scrapie incubation time genes - Cell 46: 503?511.","journal-title":"Cell"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF01313752","volume":"108","author":"P. Casaccia","year":"1989","unstructured":"CasacciaP., LadoganaA., XiY.G. and PocchiariM. (1989): Levels of infectivity in the blood throughout the incubation period of hamsters peripherally infected with scrapie - Arch. Virol. 108: 145?149.","journal-title":"Arch. Virol."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1099\/0022-1317-67-9-2005","volume":"67","author":"M. Czub","year":"1986","unstructured":"CzubM., BraigH.-R. and DiringerH. (1986 a): Pathogenesis of scrapie: Study of the temporal development of clinical symptoms, of infectivity titres and scrapie-associated fibrils in brains of hamsters infected intraperitoneally - J. Gen. Virol. 67: 2005?2009.","journal-title":"J. Gen. Virol."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF01314297","volume":"91","author":"M. Czub","year":"1986","unstructured":"CzubM., BraigH.R., B1odeH.G. and DiringerH. (1986 b): The major protein of SAF is absent from spleen and thus not an essential part of the scrapie agent -Arch. Virol. 91: 383?386.","journal-title":"Arch. Virol."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0021-9975(68)90005-4","volume":"78","author":"A.G. Dickinson","year":"1968","unstructured":"DickinsonA.G., MeikleV.M.H. and FraserH. (1968): Identification of a gene, which controls the incubation period of some strains of scrapie agent in mice - J. Comp. Path., 78: 293?299.","journal-title":"J. Comp. Path."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0021-9975(74)90023-1","volume":"84","author":"A. G. Dickinson","year":"1974","unstructured":"DickinsonA. G., StampJ.T and RenwickC.C. (1974): Maternal and lateral transmission of scrapie in sheep- J. Comp. Pathol. 84: 19?25.","journal-title":"J. Comp. Pathol."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF01309373","volume":"82","author":"H. Diringer","year":"1984","unstructured":"DiringerH. (1984): Sustained viremia in experimental hamster scrapie - Arch. Virol. 82: 105?109.","journal-title":"Arch. Virol."},{"key":"CR11","first-page":"435","volume":"33","author":"H. Diringer","year":"1990","unstructured":"DiringerH. (1990): Durchbrechen von Speziesbarieren mit unkonventionellen Viren -BGA-Blatt 33: 435?440.","journal-title":"BGA-Blatt"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/BF01120701","volume":"3","author":"H. Diringer","year":"1983","unstructured":"DiringerH. and KimberlinR.H. (1983): Infectious scrapie agent is apparently not as small as recent claims suggest - Biosci. Rep. 3: 563?568.","journal-title":"Biosci. Rep."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1099\/0022-1317-72-2-457","volume":"72","author":"H. Diringer","year":"1991","unstructured":"DiringerH. and EhlersB. (1991): Chemoprophylaxis of scrapie in mice - J. Gen. Virol. 72: 457?460.","journal-title":"J. Gen. Virol."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF01311308","volume":"118","author":"H. Diringer","year":"1991","unstructured":"DiringerH. et al. (1991): Virus-induced amyloidosis in scrapie involves a change in covalent linkages in the preamyloid - Arch. Virol. 118: 127?131.","journal-title":"Arch. Virol."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1099\/0022-1317-65-8-1325","volume":"65","author":"B. Ehlers","year":"1983","unstructured":"EhlersB. and DiringerH. (1983): Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen - J. Gen. Virol. 65: 1325?1330.","journal-title":"J. Gen. Virol."},{"key":"CR16","first-page":"457","volume":"72","author":"B. Ehlers","year":"1990","unstructured":"EhlersB. and DiringerH. (1990): Chemoprophylaxis of scrapie in mice - J. Gen. Virol. 72: 457?460.","journal-title":"J. Gen. Virol."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1099\/0022-1317-65-2-423","volume":"65","author":"B. Ehlers","year":"1984","unstructured":"EhlersB., RudolphR. and DiringerH. (1984): The reticuloendothelial system in scrapie pathogenesis -J. Gen. Virol. 65: 423?428.","journal-title":"J. Gen. Virol."},{"key":"CR18","unstructured":"Foote W. C, Call J. W, Bunch T.D. and Pitcher J.R. (1986): Embryo transfer in the control of transmission of scrapie in sheep and goats- Proceedings 90th Ann. Meeting United States Animal Health Ass., Louisville, Kentucky. pp. 413?416"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0378-1135(87)90084-8","volume":"13","author":"H. Fraser","year":"1987","unstructured":"FraserH. and FarquharC.F. (1987): Ionising irradiation has no influence on scrapie incubation period in mice - Vet. Microbiol. 13: 211?223.","journal-title":"Vet. Microbiol."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","volume":"349","author":"A. Goate","year":"1991","unstructured":"GoateA. et al. (1991): Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimers's disease - Nature 349: 704?706","journal-title":"Nature"},{"key":"CR21","first-page":"3","volume-title":"Slow transmissible diseases of the nervous system 2","author":"W.J. Hadlow","year":"1979","unstructured":"HadlowW.J., RaceR.E., KennedyR.C. and EklundC.M. (1979): Natural infection of sheep with scrapie virus. In: ?Slow transmissible diseases of the nervous system 2?. (Ed. S.B. Prusiner and W.J. Hadlow) (Academic Press, New York) pp. 3?12."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/infdis\/146.5.657","volume":"146","author":"W.J. Hadlow","year":"1982","unstructured":"HadlowW.J., KennedyR.C. and RaceR.E. (1982): Natural Infection of Suffolk sheep with scrapie virus -J. Infect. Dis. 146: 657?664.","journal-title":"J. Infect. Dis."},{"key":"CR23","first-page":"331","volume-title":"Slow Transmissible Diseases of the Nervous System","author":"J.L. Hourrigan","year":"1979","unstructured":"HourriganJ.L., KlingspornA., ClarkW.W. and deCampM. (1979): Epidemiology of scrapie in the United States. In: Slow Transmissible Diseases of the Nervous System. Vol. 1 (edts. S.B. Prusiner, W.J. Hadlow) pp. 331?356. Academic Press, New York."},{"key":"CR24","first-page":"1678","volume":"196","author":"J.L. Hourrigan","year":"1990","unstructured":"HourriganJ.L. (1990): Experimentally induced bovine spongiform encephalopathy in cattle in Mission, Tex., and the control of scrapie - JAMA 196: 1678?1679.","journal-title":"JAMA"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1099\/0022-1317-68-10-2711","volume":"68","author":"N. Hunter","year":"1987","unstructured":"HunterN., HopeJ., McConnellI. and DickinsonA.G. (1987): Linkage of the scrapie-associated fibril protein (PrP) gene and Sinc using congenic mice and restriction fragment length polymorphism analysis -J. Gen. Virol. 68: 2711?2716.","journal-title":"J. Gen. Virol."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0168-1702(89)90040-3","volume":"12","author":"R.H. Kimberlin","year":"1989","unstructured":"KimberlinR.H. and WalkerC.A. (1989): Pathogenesis of scrapie in mice after intragastric infection - Virus Res. 12: 213?220.","journal-title":"Virus Res."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.2111584","volume":"248","author":"E. Levy","year":"1990","unstructured":"LevyE. et al. (1990): Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type - Science 248: 1124?1126.","journal-title":"Science"},{"key":"CR28","volume-title":"Viral pathogenesis and immunology","author":"C.A. Mims","year":"1984","unstructured":"MimsC.A. and WhiteD.O. (1984): Viral pathogenesis and immunology - Blackwell Scient. Publ., London."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1128\/JVI.63.12.5489-5491.1989","volume":"63","author":"K. Moelling","year":"1989","unstructured":"MoellingK., SchulzeT. and DiringerH. (1989): Inhibition of human immunodeficiency virus type 1 RNase H by sulfated polyanions - J. Virol. 63: 5489?5491.","journal-title":"J. Virol."},{"key":"CR30","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1128\/JVI.65.6.2767-2772.1991","volume":"65","author":"L.A. Morrison","year":"1991","unstructured":"MorrisonL.A. and FieldsB.N. (1991): Parallel mechanisms in neuropathogenesis of enteric virus infections - J. Virol. 65: 2767?2772.","journal-title":"J. Virol."},{"key":"CR31","first-page":"333","volume":"76","author":"J.H. Pattison","year":"1964","unstructured":"PattisonJ.H. (1964): The spread of scrapie by contact between affected and healthy sheep, goats or mice -Vet. Rec. 76: 333?336.","journal-title":"Vet. Rec."},{"key":"CR32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/vr.90.17.465","volume":"90","author":"J.H. Pattison","year":"1972","unstructured":"PattisonJ.H. and WatsonW.A. (1972): Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep - Vet. Rec. 90: 465?468.","journal-title":"Vet. Rec."},{"key":"CR33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0368-1742(61)80021-0","volume":"71","author":"J.H. Pattison","year":"1961","unstructured":"PattisonJ.H. and MillsonG.C. (1961): Experimental transmission of scrapie to goats and sheep by the oral route - J. Comp. Path. 71: 171?176.","journal-title":"J. Comp. Path."},{"key":"CR34","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1021\/bi00562a028","volume":"19","author":"S.B. Prusiner","year":"1980","unstructured":"PrusinerS.B., GrothD.F., CochranS.P., MasiarzF.R., McKinleyM.P. et al. (1980): Molecular properties, partial purification and assay by incubation period measurements of the hamster scrapie agent -Biochemistry 19: 4883?4891.","journal-title":"Biochemistry"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2660001","volume":"266","author":"S.B. Prusiner","year":"1990","unstructured":"PrusinerS.B. and GabizonR. (1990): Prion liposomes- Biochem. J. 266: 1?14.","journal-title":"Biochem. J."},{"key":"CR36","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/308658a0","volume":"308","author":"R.G. Rohwer","year":"1984","unstructured":"RohwerR.G. (1984 a): Scrapie infectious agent is virus-like in size and susceptibility to inactivation -Nature 308: 658?662.","journal-title":"Nature"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.6420887","volume":"223","author":"R.G. Rohwer","year":"1984","unstructured":"RohwerR.G. (1984 b): Virus-like sensitivity of the scrapie agent to heat inactivation - Science 223: 600?602.","journal-title":"Science"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(87)90150-4","volume":"51","author":"N. Stahl","year":"1987","unstructured":"StahlN., BorcheltD.R., HasiaoK.K. and PrusinerS.G. (1987): Scrapie prion protein contains a phosphatidylinositol glycolipid - Cell 51: 229?240.","journal-title":"Cell"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0092-8674(87)90134-6","volume":"51","author":"D. Westaway","year":"1987","unstructured":"WestawayD., GoodmanP., MirendaC., McKinleyM.P., CarlsonG. et al. (1987): Distinct prion proteins in short and long scrapie incubation period mice -Cell 51: 651?662.","journal-title":"Cell"},{"key":"CR40","first-page":"638","volume":"123","author":"J.W. Wilesmith","year":"1988","unstructured":"WilesmithJ.W., WellsG.A.H., CranwellM.O. and RyanJ.B.M. (1988): Bovine spongiform encephalopathy: epidemiological studies - Vet. Rec. 123: 638?644.","journal-title":"Vet. Rec."}],"container-title":["European Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00143140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00143140\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00143140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T17:15:52Z","timestamp":1585934152000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00143140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,9]]}},"alternative-id":["BF00143140"],"URL":"https:\/\/doi.org\/10.1007\/bf00143140","relation":{},"ISSN":["0392-2990","1573-7284"],"issn-type":[{"value":"0392-2990","type":"print"},{"value":"1573-7284","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}