{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:32:44Z","timestamp":1789813964327,"version":"4.0.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Springer Semin Immunopathol"],"published-print":{"date-parts":[[1991,12]]},"DOI":"10.1007\/bf00201470","type":"journal-article","created":{"date-parts":[[2004,8,30]],"date-time":"2004-08-30T15:46:41Z","timestamp":1093880801000},"page":"217-231","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Reactivation of Epstein-Barr virus in Sj\u00f6gren's syndrome"],"prefix":"10.1007","volume":"13","author":[{"given":"Robert I.","family":"Fox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Luppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Il","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Pisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF00201470_CR1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4049\/jimmunol.130.1.203","volume":"130","author":"TC Adamson III","year":"1983","unstructured":"Adamson TC III, Fox RI, Frisman DM, Howell FV (1983) Immunohistologic analysis of lymphoid infiltrates in primary Sj\u00f6gren's syndrome using monoclonal antibodies. J Immunol 130: 203.","journal-title":"J Immunol"},{"key":"BF00201470_CR2","first-page":"971","volume-title":"Textbook of rheumatology","author":"M Alspaugh","year":"1982","unstructured":"Alspaugh M, Whaley K (1982) Sj\u00f6gren's syndrome. In: Kelly A, Harris A (eds) Textbook of rheumatology, Saunders, Philadelphia, p 971."},{"key":"BF00201470_CR3","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1084\/jem.167.5.1560","volume":"167","author":"E Ben-Chetrit","year":"1988","unstructured":"Ben-Chetrit E, Chan EKL, Sullivan KF, Tan EM (1988) A 52-kDa protein is a novel component of the SS-A-Ro antigenic particle. J Exp Med 167: 1560.","journal-title":"J Exp Med"},{"key":"BF00201470_CR4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005792-196505000-00001","volume":"44","author":"KJ Block","year":"1956","unstructured":"Block KJ, Buchanan WW, Woho MJ, Bunim JJ (1956) Sj\u00f6gren's syndrome: a clinical, pathological and serological study of 62 cases. Medicine 44: 187.","journal-title":"Medicine"},{"key":"BF00201470_CR5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.me.42.020191.000425","volume":"42","author":"KD Croen","year":"1991","unstructured":"Croen KD (1991) Latency of the human herpesviruses. Annu Rev Med 42: 61.","journal-title":"Annu Rev Med"},{"key":"BF00201470_CR6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/art.1780170514","volume":"17","author":"T Daniels","year":"1974","unstructured":"Daniels T, Sylvester RSS et al (1974) Tuboreticular structures within the labial salivary glands in Sj\u00f6gren's syndrome. Arthritis Rheum 17: 593.","journal-title":"Arthritis Rheum"},{"key":"BF00201470_CR7","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJM198704303161803","volume":"316","author":"A Fishleder","year":"1987","unstructured":"Fishleder A, Tubbs R, Hesse B, Levin H (1987) Immunoglobulin-gene rearrangement in benign lymphoepithelial lesions. N Engl J Med 316: 1118.","journal-title":"N Engl J Med"},{"key":"BF00201470_CR8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0008-8749(85)90304-1","volume":"95","author":"S Fong","year":"1985","unstructured":"Fong S, Gilbertson TA, Hueniken RJ, Singhal SK, Vaughan JH, Carson DA (1985) IgM rheumatoid factor autoantibody and immunoglobulin-producing precursor cells in the bone marrow of humans. Cell Immunol 95: 157.","journal-title":"Cell Immunol"},{"key":"BF00201470_CR9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1172\/JCI110984","volume":"72","author":"RI Fox","year":"1983","unstructured":"Fox RI, Adamson TC III, Fong S, Robinson CA, Morgan EL, Robb JA, Howell FV (1983) Lymphocyte phenotype and function of pseudolymphomas associated with Sj\u00f6gren's syndrome. J Clin Invest 72: 52.","journal-title":"J Clin Invest"},{"key":"BF00201470_CR10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4049\/jimmunol.135.1.207","volume":"135","author":"RI Fox","year":"1985","unstructured":"Fox RI, Hugli TE, Lanier LL, Morgan EL, Howell F (1985) Salivary gland lymphocytes in primary Sj\u00f6gren's syndrome lack lymphocyte subsets defined by Leu 7 and Leu 11 antigens. J Immunol 135: 207.","journal-title":"J Immunol"},{"key":"BF00201470_CR11","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.4049\/jimmunol.135.5.3109","volume":"135","author":"RI Fox","year":"1985","unstructured":"Fox RI, Theofilopolos AN, Altoman A (1985) Production of interleukin 2 (IL 2) by salivary gland lymphocytes in Sj\u00f6gren's syndrome. Detection of reactive cells by using antibody directed to synthetic peptides of IL 2. J Immunol 135: 3109.","journal-title":"J Immunol"},{"key":"BF00201470_CR12","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/art.1780290908","volume":"29","author":"RI Fox","year":"1986","unstructured":"Fox RI, Bumol T, Fantozzi R, Bone R, Schreiber R (1986) Expression of histocompatibility antigen HLA-DR by salivary gland epithelial cells in Sj\u00f6gren's syndrome. Arthritis Rheum 29: 1105.","journal-title":"Arthritis Rheum"},{"key":"BF00201470_CR13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.136.2.477","volume":"136","author":"RI Fox","year":"1986","unstructured":"Fox RI, Chen PP, Carson DA, Fong S (1986) Expression of a cross-reactive idiotype on rheumatoid factor in patients with Sj\u00f6gren's syndrome. J Immunol 136: 477.","journal-title":"J Immunol"},{"key":"BF00201470_CR14","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.4049\/jimmunol.137.10.3162","volume":"137","author":"RI Fox","year":"1986","unstructured":"Fox RI, Pearson G, Vaughan JH (1986) Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sj\u00f6gren's syndrome. J Immunol 137: 3162.","journal-title":"J Immunol"},{"key":"BF00201470_CR15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jcla.1860010123","volume":"1","author":"RI Fox","year":"1987","unstructured":"Fox RI, Scott S, Houghton R, Whalley A, Geltofsky J, Vaughan JH, Smith R (1987) Synthetic peptide derived from the Epstein-Barr virus-encoded early diffuse antigen (EA-D) reactive with human antibodies. J Clin Lab Anal 1: 140.","journal-title":"J Clin Lab Anal"},{"key":"BF00201470_CR16","first-page":"1158","volume":"317","author":"B Freimark","year":"1987","unstructured":"Freimark B, Fox RI (1987) Letter. N Engl J Med 317: 1158.","journal-title":"N Engl J Med"},{"key":"BF00201470_CR17","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/j.2326-5205.1989.tb00017.x","volume":"32","author":"B Freimark","year":"1989","unstructured":"Freimark B, Fantozzi R, Bone R, Bordin G, Fox R (1989) Detection of clonally expanded salivary gland lymphocytes in Sj\u00f6gren's syndrome. Arthritis Rheum 32: 859.","journal-title":"Arthritis Rheum"},{"key":"BF00201470_CR18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1172\/JCI112892","volume":"79","author":"KK Gaither","year":"1987","unstructured":"Gaither KK, Fox OW, Yamagata H, Mamula MJ, Reichlin M, Harly JB (1987) Implications of anti-Ro\/Sjogren's syndrome A antigen autoantibody in normal sera for autoimmunity. J Clin Invest 79: 842.","journal-title":"J Clin Invest"},{"key":"BF00201470_CR19","first-page":"558","volume":"17","author":"JS Gaston","year":"1990","unstructured":"Gaston JS, Rowe M, Bacon P (1990) Sj\u00f6gren's syndrome after infection by Epstein-Barr virus. J Rheumatol 17: 558.","journal-title":"J Rheumatol"},{"key":"BF00201470_CR20","first-page":"376","volume":"32","author":"A Gougerout","year":"1925","unstructured":"Gougerout A (1925) Insuffisance pregressive et atrophie des glandes salivaires et muqueuses de la bouche, des conjonctives (et parfois des muqueuses, nasale, laryngee, vulvarie). \u201cSecheresse\u201d de la bouche, des conjonctives, etc. Bull Soc Fr Dermatol Syphiliar 32: 376.","journal-title":"Bull Soc Fr Dermatol Syphiliar"},{"key":"BF00201470_CR21","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/art.1780310406","volume":"31","author":"RG Hamilton","year":"1988","unstructured":"Hamilton RG, Harley JB, Bias WB et al (1988) Two Ro (SS-A) autoantibody responses in systemic lupus erythematous. Arthritis Rheum 31: 446.","journal-title":"Arthritis Rheum"},{"key":"BF00201470_CR22","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/art.1780290207","volume":"29","author":"JB Harley","year":"1986","unstructured":"Harley JB, Alexander EL, Bias WB, Fox OF, Provost TT, Richlin M, Yanagata H, Arnett FC (1986) Anti-Ro (SS-A) and Anti-La (SS-B) in patients with Sj\u00f6gren's syndrome. Arthritis Rheum 29: 196.","journal-title":"Arthritis Rheum"},{"key":"BF00201470_CR23","doi-asserted-by":"crossref","first-page":"888","DOI":"10.7326\/0003-4819-89-6-888","volume":"89","author":"SS Kassan","year":"1978","unstructured":"Kassan SS, Thomas TL, Moutsopoulos HM, Hoover R, Kimberly RP, Budman DR, Costa J, Decker JL, Chused TM (1978) Increased risk of lymphoma in sicca syndrome. Ann Intern Med 89: 888.","journal-title":"Ann Intern Med"},{"key":"BF00201470_CR24","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1073\/pnas.78.2.805","volume":"78","author":"M Lerner","year":"1982","unstructured":"Lerner M, Andrews N, Miller J, etal (1982) Two small RNA's encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. Proc Natl Acad Sci USA 78: 805.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF00201470_CR25","first-page":"475","volume":"61","author":"G Lindahl","year":"1985","unstructured":"Lindahl G, Hedfors E, Kloreskig L, Forsum U (1985) Epithelial HLA-DR expression and T cell subsets in salivary glands in Sj\u00f6gren's syndrome. Clin Exp Immunol 61: 475.","journal-title":"Clin Exp Immunol"},{"key":"BF00201470_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197501022920101","volume":"292","author":"R Lukes","year":"1975","unstructured":"Lukes R, Tindle B (1975) Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease. N Engl J Med 292: 1.","journal-title":"N Engl J Med"},{"key":"BF00201470_CR27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0002-9343(91)90567-H","volume":"90","author":"X Mariette","year":"1991","unstructured":"Mariette X, Gozlan J, Clerc D, Bisson M, Morinet F (1991) Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sj\u00f6gren's syndrome. Am J Med 90: 286.","journal-title":"Am J Med"},{"key":"BF00201470_CR28","unstructured":"Mikulicz JH (1982) \u00dcber eine eigenartige symmetrische Erkrankung der Tr\u00e4nen- und Mundspeicheldr\u00fcsen. In: Billroth GT (ed) Beitr Chir Fortschr, Stuttgart, pp 610\u2013620."},{"key":"BF00201470_CR29","first-page":"471","volume":"29","author":"W Morgan","year":"1953","unstructured":"Morgan W, Castleman B (1953) A clinicopathologic study of Mikulicz'a disease. Am J Pathol 29: 471.","journal-title":"Am J Pathol"},{"key":"BF00201470_CR30","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/art.1780220816","volume":"22","author":"P Pierce","year":"1979","unstructured":"Pierce P, Stern R, Jaffe R, etal (1979) Immunoblastic sarcoma with features of Sj\u00f6gren's syndrome and SLE in a patient with immunoblastic lymphadenopathy. Arthritis Rheum 22: 911.","journal-title":"Arthritis Rheum"},{"key":"BF00201470_CR31","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1172\/JCI114014","volume":"83","author":"MD Rader","year":"1989","unstructured":"Rader MD, O'Brien C, Liu Y, Harley JB, Reichlin M (1989) Heterogeneity of the Ro\/SSA antigen. J Clin Invest 83: 1293.","journal-title":"J Clin Invest"},{"key":"BF00201470_CR32","first-page":"221","volume-title":"Diseases of the salivary gland","author":"P Rankow","year":"1976","unstructured":"Rankow P, Polayes I (1976) Inflammatory conditions of the salivary gland. In: Rankow P (ed) Diseases of the salivary gland. W.B. Saunders, Philadelphia, pp 221\u2013239."},{"key":"BF00201470_CR33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4049\/jimmunol.134.1.211","volume":"134","author":"G Rhodes","year":"1985","unstructured":"Rhodes G, Carson DA, Valbracht J, Houghten R, Vaughan JH (1985) Human immune responses to synthetic peptides from the Epstein-Barr nuclear antigen. J Immunol 134: 211.","journal-title":"J Immunol"},{"key":"BF00201470_CR34","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1084\/jem.169.6.2191","volume":"169","author":"I Saito","year":"1989","unstructured":"Saito I, Servenius B, Compton T, Fox RI (1989) Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sj\u00f6gren's syndrome. J Exp Med 169: 2191.","journal-title":"J Exp Med"},{"key":"BF00201470_CR35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00443482","volume":"395","author":"U Schmid","year":"1982","unstructured":"Schmid U, Helbron D, Lennert K (1982) Development of malignant lympyhoma in myoepithelial sialadenitis (Sj\u00f6gren's syndrome). Virchows Arch [A] 395: 11.","journal-title":"Virchows Arch [A]"},{"key":"BF00201470_CR36","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1172\/JCI113039","volume":"80","author":"AL Sestak","year":"1987","unstructured":"Sestak AL, Harley JB, Yoshida S, Reichlin M (1987) Lupus\/Sj\u00f6gren's autoantibody specificities in sera with paraproteins. J Clin Invest 80: 138.","journal-title":"J Clin Invest"},{"key":"BF00201470_CR37","first-page":"1","volume":"2","author":"HS Sj\u00f6gren","year":"1933","unstructured":"Sj\u00f6gren HS (1933) Zur Kenntnis der keratoconjunctivitis sicca (Keratitis folliformis bei Hypofunktion der Tr\u00e4nendr\u00fcsen). Acta Opthalmol (Copenh) 2: 1.","journal-title":"Acta Opthalmol (Copenh)"},{"key":"BF00201470_CR38","first-page":"247","volume":"25","author":"DA Thorley-Lawson","year":"1988","unstructured":"Thorley-Lawson DA (1988) Basic virological aspects of Epstein-Barr virus infection. Semin Hematol 25: 247.","journal-title":"Semin Hematol"},{"key":"BF00201470_CR39","volume-title":"Curr Top Microbiol Immunol","author":"W van Eden","year":"1988","unstructured":"van Eden W, Hogervorst J, Hensen E, van der Zee R, van Embden J, Cohen I (1988) Gillis S (ed) Curr Top Microbiol Immunol, Plenum Press, New York."},{"key":"BF00201470_CR40","first-page":"513","volume":"66","author":"K Whaley","year":"1973","unstructured":"Whaley K, Webb J, McAvoy B, Hughes GR, Lee P, MacSween RN, Buchanan WW (1973) Sj\u00f6gren's syndrome. II. Clinical associations and immunological phenomena. Q J Med 66: 513.","journal-title":"Q J Med"},{"key":"BF00201470_CR41","doi-asserted-by":"crossref","first-page":"490","DOI":"10.7326\/0003-4819-102-4-490","volume":"102","author":"S Whittingham","year":"1985","unstructured":"Whittingham S, McNeilage J, Mackay IR (1985) Primary Sj\u00f6gren's syndrome after infectious mononucleosis. Ann Intern Med 102: 490.","journal-title":"Ann Intern Med"},{"key":"BF00201470_CR42","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1128\/jvi.51.3.795-798.1984","volume":"51","author":"H Wolf","year":"1984","unstructured":"Wolf H, Haus M, Wilmes E (1984) Persistence of Epstein-Barr virus in the parotid gland. J Virol 51: 795.","journal-title":"J Virol"},{"key":"BF00201470_CR43","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1073\/pnas.81.7.1996","volume":"81","author":"SL Wolin","year":"1984","unstructured":"Wolin SL, Steitz JA (1984) The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs. Proc Natl Acad Sci USA 81: 1996.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Springer Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00201470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF00201470\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00201470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00201470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T13:42:00Z","timestamp":1744033320000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF00201470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["BF00201470"],"URL":"https:\/\/doi.org\/10.1007\/bf00201470","relation":{},"ISSN":["0344-4325","1432-2196"],"issn-type":[{"value":"0344-4325","type":"print"},{"value":"1432-2196","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]},"assertion":[{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}