{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:56:19Z","timestamp":1757703379780},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1987,5,1]],"date-time":"1987-05-01T00:00:00Z","timestamp":546825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[1987,5]]},"DOI":"10.1007\/bf00215481","type":"journal-article","created":{"date-parts":[[2004,9,16]],"date-time":"2004-09-16T23:39:52Z","timestamp":1095377992000},"page":"68-72","source":"Crossref","is-referenced-by-count":17,"title":["Anti-apomorphine effects of phenothiazine drug metabolites"],"prefix":"10.1007","volume":"92","author":[{"given":"E.","family":"Morel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.G.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.G.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"436","volume":"21","author":"KP Bhargava","year":"1963","unstructured":"Bhargava KP, Chandra OM (1963) Anti-emetic activity of phenothiazines in relation to their chemical structure. Br J Pharmacol 21:436?440","journal-title":"Br J Pharmacol"},{"key":"CR2","first-page":"81","volume":"217","author":"DB Bylund","year":"1981","unstructured":"Bylund DB (1981) Interactions of neuroleptic metabolites with dopaminergic, alpha adrenergic and muscarinic cholinergic receptors. J Pharmacol Exp Ther 217:81?86","journal-title":"J Pharmacol Exp Ther"},{"key":"CR3","first-page":"25","volume":"17","author":"S Courvoisier","year":"1956","unstructured":"Courvoisier S (1956) Pharmacodynamic basis for the use of chlorpromazine in psychiatry. J Clin Exp Psychopathol 17:25?37","journal-title":"J Clin Exp Psychopathol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(78)90236-4","volume":"47","author":"I Creese","year":"1978","unstructured":"Creese I, Manian AA, Prosser TD, Snyder SH (1978) 3H-Haloperidol binding to dopamine receptors in the rat corpus striatum: influence of chlorpromazine metabolites and derivatives. Eur J Pharmacol 47:291?296","journal-title":"Eur J Pharmacol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-349-05929-4_10","volume-title":"Clinical pharmacology in psychiatry. Neuroleptic and antidepressant research","author":"SG Dahl","year":"1981","unstructured":"Dahl SG (1981) Active metabolites of phenothiazine drugs. In: Usdin E, Dahl SG, Gram LF, Lingj\u00e6rde O (eds) Clinical pharmacology in psychiatry. Neuroleptic and antidepressant research. Macmillan, London, pp 125?137"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00007691-198204000-00005","volume":"4","author":"SG Dahl","year":"1982","unstructured":"Dahl SG (1982) Active metabolites of neuroleptic drugs: Possible contribution to therapeutic and toxic effects. Ther Drug Monit 4:33?40","journal-title":"Ther Drug Monit"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/jps.2600660214","volume":"66","author":"SG Dahl","year":"1977","unstructured":"Dahl SG, Garle M (1977) Identification of non-polar methotrimeprazine metabolites in plasma and urine by GLC-mass spectrometry. J Pharm Sci 66:190?193","journal-title":"J Pharm Sci"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00432672","volume":"74","author":"SG Dahl","year":"1981","unstructured":"Dahl SG, Hall H (1981) Binding affinity of levomepromazine and two of its major metabolites to central dopamine and ?-adrenergic receptors in the rat. Psychopharmacology 74:101?104","journal-title":"Psychopharmacology"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0014-2999(76)90031-5","volume":"37","author":"SG Dahl","year":"1976","unstructured":"Dahl SG, Refsum H (1976) Effects of levomepromazine, chlorpromazine and their sulphoxides on isolated rat atria. Eur J Pharmacol 37:241?248","journal-title":"Eur J Pharmacol"},{"key":"CR10","first-page":"409","volume":"21","author":"SG Dahl","year":"1982","unstructured":"Dahl SG, Hjorth M, Hough E (1982a) Chlorpromazine, methotrimeprazine and metabolites. Structural changes accompanying the loss of neuroleptic potency by ring sulfoxidation. Mol Pharmacol 21:409?414","journal-title":"Mol Pharmacol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/bms.1200091207","volume":"9","author":"SG Dahl","year":"1982","unstructured":"Dahl SG, Johnsen H, Lee CR (1982b) Gas chromatographic mass spectrometric identification of O-demethylated and mono-hydroxylated metabolites of levomepromazine in blood from psychiatric patients by selected ion recording with high resolution. Biomed Mass Spectrom 9:534?538","journal-title":"Biomed Mass Spectrom"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0006-2952(86)90269-8","volume":"35","author":"SG Dahl","year":"1986","unstructured":"Dahl SG, Hough E, Hals P-A (1986) Phenothiazine drugs and metabolites: Molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol 35:1263?1269","journal-title":"Biochem Pharmacol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/jps.2600600605","volume":"60","author":"J Dreyfuss","year":"1971","unstructured":"Dreyfuss J, Cohen AI (1971) Identification of 7-hydroxyfluphenazine as major metabolite of fluphenazine-14C in the dog. J Pharm Sci 60:826?828","journal-title":"J Pharm Sci"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/jps.2600600604","volume":"60","author":"J Dreyfuss","year":"1971","unstructured":"Dreyfuss J, Ross JJ, Schreiber EC (1971) Biological disposition and metabolic fate of fluphenazine-14C in the dog. J Pharm Sci 60:821?825","journal-title":"J Pharm Sci"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0014-2999(86)90793-4","volume":"125","author":"P-A Hals","year":"1986","unstructured":"Hals P-A, Hall H, Dahl SG (1986) Phenothiazine drug metabolites: Dopamine D2 receptor, ?1- and ?2-adrenoeceptor binding. Eur J Pharmacol 125:373?381","journal-title":"Eur J Pharmacol"},{"key":"CR16","first-page":"63","volume":"10","author":"H Johnsen","year":"1982","unstructured":"Johnsen H, Dahl SG (1982) Identification of O-demethylated and ring-hydroxylated metabolites of methotrimeprazine (levomepromazine) in man. Drug Metab Dispos 10:63?67","journal-title":"Drug Metab Dispos"},{"key":"CR17","first-page":"111","volume-title":"Progress in drug metabolism, vol 9","author":"A J\u00f8rgensen","year":"1986","unstructured":"J\u00f8rgensen A (1986) Metabolism and pharmacokinetics of antipsychotic drugs. In: Bridges JW, Chasseaud LF (eds) Progress in drug metabolism, vol 9. Taylor and Francis, London, pp 111?174"},{"key":"CR18","first-page":"334","volume":"231","author":"CD Kilts","year":"1984","unstructured":"Kilts CD, Knight DL, Mailman RB, Widerl\u00f6w E, Breese GR (1984) Effects of thioridazine and its metabolites on dopaminergic function: Drug metabolism as a determinant of the anti-dopaminergic actions of thioridazine. J Pharmacol Exp Ther 231:334?342","journal-title":"J Pharmacol Exp Ther"},{"key":"CR19","first-page":"539","volume":"225","author":"MH Lewis","year":"1983","unstructured":"Lewis MH, Widerl\u00f6v E, Knight D, Kilts Cd, Mailman RB (1983) N-Oxides of phenothiazine antipsychotics: Effects on in vivo and in vitro estimates of dopaminergic function. J Pharmacol Exp Ther 225:539?545","journal-title":"J Pharmacol Exp Ther"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0024-3205(71)90010-5","volume":"10","author":"AA Manian","year":"1971","unstructured":"Manian AA, Efron DH, Harris SR (1971) Appearance of mono-hydroxylated chlorpromazine metabolites in the central nervous system. Life Sci 10:679?684","journal-title":"Life Sci"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00634146","volume":"50","author":"P Protais","year":"1976","unstructured":"Protais P, Costentin J, Schwartz JC (1976) Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology 50:1?6","journal-title":"Psychopharmacology"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF00429006","volume":"81","author":"P Protais","year":"1983","unstructured":"Protais P, Bonnet JJ, Costentin J (1983) Pharmacological characterization of the receptors involved in the apomorphine-induced polyphasic modifications of locomotor activity in mice. Psychopharmacology 81:126?134","journal-title":"Psychopharmacology"},{"key":"CR23","first-page":"229","volume":"32","author":"P Seeman","year":"1980","unstructured":"Seeman P (1980) Brain dopamine receptors. Pharmacol Rev 32:229?313","journal-title":"Pharmacol Rev"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.2042-7158.1976.tb04082.x","volume":"28","author":"R Whelpton","year":"1976","unstructured":"Whelpton R, Curry SH (1976) Methods for study of fluphenazine kinetics in man. J Pharm Pharmacol 28:869?873","journal-title":"J Pharm Pharmacol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-1-349-05929-4_9","volume-title":"Clinical pharmacology in psychiatry. Neuroleptic and antidepressant research","author":"D Wiles","year":"1981","unstructured":"Wiles D (1981) Preliminary assessment of a calf caudate radioreceptor assay for the estimation of neuroleptic drugs in plasma: comparison with other techniques. In: Usdin E, Dahl SG, Gram LF, Lingj\u00e6rde O (eds) Clinical pharmacology in psychiatry. Neuroleptic and antidepressant research. Macmillan, London, pp 111?121"},{"key":"CR26","first-page":"93","volume-title":"Neuroleptics: Neurochemical, behavioral and clinical perspectives","author":"P Worms","year":"1983","unstructured":"Worms P, Broekkamp CLE, Lloyd KG (1983) Behavioral effects of neuroleptics. In: Coyle JT, Enna SJ (eds) Neuroleptics: Neurochemical, behavioral and clinical perspectives, Raven, New York, pp 93?117"},{"key":"CR27","first-page":"76","volume":"248","author":"K Yamada","year":"1980","unstructured":"Yamada K, Furukawa T (1980) Behavior of rats and mice administered active metabolites of fluphenazine, 7-hydroxy-fluphenazine and fluphenazine-sulphoxide. Arch Int Pharmacodyn 248:76?85","journal-title":"Arch Int Pharmacodyn"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00215481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00215481\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00215481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:11:50Z","timestamp":1554768710000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00215481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["BF00215481"],"URL":"https:\/\/doi.org\/10.1007\/bf00215481","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}