{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:07:14Z","timestamp":1772467634550,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[1989]]},"DOI":"10.1007\/bf00228075","type":"journal-article","created":{"date-parts":[[2004,9,26]],"date-time":"2004-09-26T22:25:45Z","timestamp":1096237545000},"page":"23-31","source":"Crossref","is-referenced-by-count":90,"title":["Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance"],"prefix":"10.1007","volume":"91","author":[{"given":"Robert F. A.","family":"Zwaal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard M.","family":"Bevers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Comfurius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Rosing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland H. J.","family":"Tilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F. J.","family":"Verhallen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0304-4157(73)90003-8","volume":"300","author":"RFA Zwaal","year":"1973","unstructured":"Zwaal RFA, Roelofsen B, Colley CM: Localization of red cell membrane constituents. Biochim Biophys Acta 300: 159?182,1973","journal-title":"Biochim Biophys Acta"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.bi.48.070179.000403","volume":"48","author":"JAF Op den Kamp","year":"1979","unstructured":"Op den Kamp JAF: Lipid asymmetry in membranes. Annu Rev Biochem 48: 47?71, 1979","journal-title":"Annu Rev Biochem"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-4157(78)90003-5","volume":"515","author":"RFA Zwaal","year":"1978","unstructured":"Zwaal RFA: Membrane and lipid involvement in blood coagulation. Biochim Biophys Acta 515: 163?205, 1978","journal-title":"Biochim Biophys Acta"},{"key":"CR4","doi-asserted-by":"crossref","unstructured":"Zucker MB, Nachmias VT: Platelet activation. Atherosclerosis 5: 2?18","DOI":"10.1161\/01.ATV.5.1.2"},{"key":"CR5","unstructured":"Bevers EM, Rosing J, Zwaal RFA: Platelets and coagulation. In: EB MacIntyre and J Gordon (Eds) Platelets in Biology and Pathology. Elsevier, 1987, vol. 3, pp. 127?160"},{"key":"CR6","first-page":"189","volume":"20","author":"J Palek","year":"1983","unstructured":"Palek J, Lux SE: Red cell membrane skeletal defects in hereditary and acquired hemolytic anemias. Semin Hematol 20: 189?224, 1983","journal-title":"Semin Hematol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI108390","volume":"57","author":"PK Schick","year":"1976","unstructured":"Schick PK, Kurica KB, Chacko GK: Location of phosphatidylethanolamine and phosphatidylserine in the human platelet plasma membrane. J Clin Invest 57: 1221?1226, 1976","journal-title":"J Clin Invest"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0005-2736(83)90169-4","volume":"736","author":"EM Bevers","year":"1983","unstructured":"Bevers EM, Comfurius P, Zwaal RFA: Changes in membrane phospholipid distribution during platelet activation. Biochim Biophys Acta 736: 57?66, 1983","journal-title":"Biochim Biophys Acta"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0005-2736(85)90485-7","volume":"85","author":"P Comfurius","year":"1985","unstructured":"Comfurius P, Bevers EM, Zwaal RFA: The involvement of cytoskeleton in the regulation of transbilayer movement of phospholipids in human blood platelets. Biochim Biophys Acta 85: 143?148, 1985","journal-title":"Biochim Biophys Acta"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood.V65.2.319.319","volume":"65","author":"J Rosing","year":"1985","unstructured":"Rosing J, van Rijn JLML, Bevers EM, van Dieijen G, Comfurius P, Zwaal RFA: The role of activated human platelets in prothrombin and factor X activation. Blood 65: 319?332, 1985","journal-title":"Blood"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1021\/bi00401a002","volume":"27","author":"J Rosing","year":"1988","unstructured":"Rosing J, Speijer H, Zwaal RFA: Prothrombin activation on phospholipid membranes with positive electrostatic potential. Biochemistry 27: 8?11, 1988","journal-title":"Biochemistry"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood.V65.6.1557.bloodjournal6561557","volume":"65","author":"J Rosing","year":"1985","unstructured":"Rosing J, Bevers EM, Comfurius J, Hemker HC, van Dieijen G, Weiss HJ, Zwaal RFA: Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder. Blood 65: 1557?1561, 1985","journal-title":"Blood"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1172\/JCI111672","volume":"75","author":"PFH Franck","year":"1985","unstructured":"Franck PFH, Bevers EM, Lubin H, Comfurius P, Chin DT, Op den Kamp JAF, Zwaal RFA, van Deenen LLM, Roelofsen B: Uncoupling of the membrane skeleton from the lipid bilayer: the cause of accelerated phospholipid flip-flop leading to enhanced procoagulant activity of sickle cells. J Clin Invest 75: 183?190, 1985","journal-title":"J Clin Invest"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0304-4157(82)90001-6","volume":"694","author":"CWM Haest","year":"1982","unstructured":"Haest CWM: Interactions between membrane skeleton proteins and the intrinsic domain of the erythrocyte membrane. Biochim Biophys Acta 694: 331?352, 1982","journal-title":"Biochim Biophys Acta"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/295612a0","volume":"295","author":"D Allan","year":"1982","unstructured":"Allan D, Limbrick AR, Thomas P, Westerman MP: Release of spectrin free spicules on reoxygenation of sickled erythrocytes. Nature Lond 295: 612?613, 1982","journal-title":"Nature Lond"},{"key":"CR16","volume-title":"Thesis","author":"PFJ Verhallen","year":"1988","unstructured":"Verhallen PFJ: Involvement of platelet cytoskeleton and plasma membrane in the expression of procoagulant activity. Thesis, University of Limburg, Maastricht, 1988"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1021\/bi00357a046","volume":"25","author":"A Zachowski","year":"1986","unstructured":"Zachowski A, Favre E, Cribier S, Herv\u00e9 P, Devaux PF: Outside-inside translocation of aminophospholipids in the human erythrocyte membrane is mediated by a specific enzyme. Biochemistry 25: 2585?2590, 1986","journal-title":"Biochemistry"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-5793(86)80044-8","volume":"194","author":"L Tilley","year":"1986","unstructured":"Tilley L, Cribier S, Roelofsen B, Op den Kamp JAF, van Deenen LLM: ATP-dependent translocation of aminophospholipids in human erythrocyte membranes. FEBS Lett 194: 21?27, 1986","journal-title":"FEBS Lett"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1021\/bi00385a003","volume":"26","author":"A Sune","year":"1987","unstructured":"Sune A, Bette-Bobillo P, Bienvenue A, Fellmann P, Devaux PF: Selective outside-inside translocation of aminophospholipids in human platelets. Biochemistry 26: 2972?2978, 1987","journal-title":"Biochemistry"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0014-5793(88)81291-2","volume":"234","author":"PF Devaux","year":"1988","unstructured":"Devaux PF: Phospholipid flippases. FEBS Lett 234: 8?12, 1988","journal-title":"FEBS Lett"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1021\/bi00403a002","volume":"27","author":"J Connor","year":"1988","unstructured":"Connor J, Schroit AJ: Transbilayer movement of phosphatidylserine in erythrocytes; inhibition of transport and preferential labelling of a 31 kD protein by sulfhydryl reactive reagents. Biochemistry 27: 848?851, 1988","journal-title":"Biochemistry"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1016\/S0021-9258(18)45658-X","volume":"262","author":"OC Martin","year":"1987","unstructured":"Martin OC, Pagano RE: Transbilayer movement of fluorescent analogs of phosphatidylserine and phosphatidylethanolamine at the plasma membrane of cultured cells; evidence for a protein-mediated and ATP-dependent process. J Biol Chem 262: 5890?5898, 1987","journal-title":"J Biol Chem"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1016\/S0021-9258(18)89189-X","volume":"260","author":"AJ Schroit","year":"1985","unstructured":"Schroit AJ, Madsen JW, Tanaka Y: In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes. J Biol Chem 260: 5131?5138, 1985","journal-title":"J Biol Chem"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/bj2460103","volume":"246","author":"P Joshi","year":"1987","unstructured":"Joshi P, Dutta GP, Gupta CM: An intracellular simian malarial parasite (Plasmodium Knowlesi) induces stageindependent alterations in membrane phospholipid organization of its host erythrocyte. Biochem J 246: 103?108, 1987","journal-title":"Biochem J"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2141.1988.tb06198.x","volume":"68","author":"P Joshi","year":"1988","unstructured":"Joshi P, Gupta CM: Abnormal membrane phospholipid organization in Plasmodium falciparum-infected erythrocytes. Brit J Haematol 68: 255?259, 1988","journal-title":"Brit J Haematol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00228075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00228075\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00228075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T23:27:22Z","timestamp":1624663642000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00228075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989]]},"references-count":25,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1989]]}},"alternative-id":["BF00228075"],"URL":"https:\/\/doi.org\/10.1007\/bf00228075","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989]]}}}