{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:00:09Z","timestamp":1770721209259,"version":"3.49.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[1995,1]]},"DOI":"10.1007\/bf00262300","type":"journal-article","created":{"date-parts":[[2004,11,6]],"date-time":"2004-11-06T14:25:32Z","timestamp":1099751132000},"page":"213-219","source":"Crossref","is-referenced-by-count":53,"title":["Activated CD4+ and CD8+ T-cell subsets in Wegener's granulomatosis"],"prefix":"10.1007","volume":"14","author":[{"given":"M.","family":"Schlesier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kaspar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gutfleisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Wolff-Vorbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. -H.","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/art.1780330807","volume":"33","author":"RY Leavitt","year":"1990","unstructured":"Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP, Calabrese LH, Fries JF, Lie JT, Lightfoot RW Jr, et al (1990) The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum 33:1101?1107","journal-title":"Arthritis Rheum"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00002281-199102000-00003","volume":"3","author":"RY Leavitt","year":"1991","unstructured":"Leavitt RY, Fauci AS (1991) Wegener's granulomatosis. Curr Opin Rheumatol 3:8?14","journal-title":"Curr Opin Rheumatol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(85)91147-X","volume":"I","author":"FJ Woude Van der","year":"1985","unstructured":"Van der Woude FJ, Rasmussen N, Lobatto S, Wiik A, Permin H, Van Es LA, van der Giessen M, van der Hem GK, The TH (1985) Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet I:425?429","journal-title":"Lancet"},{"key":"CR4","first-page":"350","volume":"69","author":"G L\u00fcdemann","year":"1987","unstructured":"L\u00fcdemann G, Gross WL (1987) Autoantibodies against cytoplasmic structures of neutrophil granulocytes in Wegener's granulomatosis. Clin Exp Immunol 69:350?357","journal-title":"Clin Exp Immunol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1182\/blood.V82.4.1221.1221","volume":"82","author":"W-J Mayet","year":"1993","unstructured":"Mayet W-J, Csernok E, Szymkowiak C, Gross WL, Meyer Zum B\u00fcschenfelde K-H (1993) Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis. Blood 82:1221?1229","journal-title":"Blood"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.1993.tb03345.x","volume":"91","author":"WL Gross","year":"1993","unstructured":"Gross WL, Schmitt WH, Csernok E (1993) ANCA and associated diseases: immunodiagnostic and pathogenetic aspects. Clin Exp Immunol 91:1?12","journal-title":"Clin Exp Immunol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1182\/blood.V81.8.1996.1996","volume":"81","author":"EC Hagen","year":"1993","unstructured":"Hagen EC, Ballieux BEPB, Van Es LA, Daha MR, Van der Woude FJ (1993) Antineutrophil cytoplasmic autoantibodies: a review of the antigens involved, the assays, and the clinical and possible pathogenetic consequences. Blood 81:1996?2002","journal-title":"Blood"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/0002-9343(83)91030-6","volume":"74","author":"GN Gephardt","year":"1983","unstructured":"Gephardt GN, Ahmad M, Tubbs RR (1983) Pulmonary vasculitis (Wegener's granulomatosis). Immunohistochemical study of T and B cell markers. Am J Med 74:700?704","journal-title":"Am J Med"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000166898","volume":"5","author":"IJ Berge ten","year":"1985","unstructured":"ten Berge IJ, Wilmink JM, Meyer CJ, Surachno J, ten Veen KH, Balk TG, Schellekens PT (1985) Clinical and immunological follow-up of patients with severe renal disease in Wegener's granulomatosis. Am J Nephrol 5:21?29","journal-title":"Am J Nephrol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/art.1780350914","volume":"35","author":"WH Schmitt","year":"1992","unstructured":"Schmitt WH, Heesen C, Csernok E, Rautmann A, Gross WL (1992) Elevated serum levels of soluble interleukin-2 receptor in patients with Wegener's granulomatosis. Association with disease activity. Arthritis Rheum 35:1088?1096","journal-title":"Arthritis Rheum"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2249.1993.tb05918.x","volume":"91","author":"CA Stegeman","year":"1993","unstructured":"Stegeman CA, Cohen Tervaert JW, Huitema MG, Kallenberg CGM (1993) Serum markers of T cells activation in relapses of Wegener's granulomatosis. Clin Exp Immunol 91:415?420","journal-title":"Clin Exp Immunol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-1-4757-9182-2_69","volume":"336","author":"J Gutfleisch","year":"1993","unstructured":"Gutfleisch J, Baumert E, Wolff-Vorbeck G, Schlesier M, Strutz HJ, Peter HH (1993) Increased expression of CD25 and adhesion molecules on peripheral blood lymphocytes of patients with Wegener's granulomatosis (WG) and ANCA positive vasculitides. Adv Exp Med Biol 336:397?404","journal-title":"Adv Exp Med Biol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000236574","volume":"102","author":"M Ikeda","year":"1993","unstructured":"Ikeda M, Watanabe Y, Kitahara S, Inouye T (1993) Distinctive increases in HLA-DR+ and CD8+ 57+ lymphocyte subsets in Wegener's granulomatosis. Int Arch Allergy Immunol 102: 205?108","journal-title":"Int Arch Allergy Immunol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/jlb.54.2.161","volume":"54","author":"A Sheldon","year":"1993","unstructured":"Sheldon A, Flego L, Zola H (1993) Coexpression of IL-2 receptor p55 and p57 by circulating blood lymphocytes. J Leukocyte Biol 54:161?167","journal-title":"J Leukocyte Biol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.4049\/jimmunol.151.4.2237","volume":"151","author":"T Hoshino","year":"1993","unstructured":"Hoshino T, Yamada A, Honda J, Imai Y, Nakao M, Inoue M, Sagawa K, Yokoyama MM, Oizumi K, Itoh K (1993) Tissuespecific distribution and age-dependent increase of human CD11b+ T cells. J Immunol 151:2237?2246","journal-title":"J Immunol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0090-1229(91)90068-L","volume":"60","author":"MS Freedman","year":"1991","unstructured":"Freedman MS, Rujis TC, Blain M, Antel JP (1991) Phenotypic and functional characteristics of activated CD8+ cells: a CD11b-CD28? subset mediates noncytolytic functional suppression. Clin Immunol Immunopathol 60:254?267","journal-title":"Clin Immunol Immunopathol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.4049\/jimmunol.150.4.1147","volume":"150","author":"M Azuma","year":"1993","unstructured":"Azuma M, Phillips JH, Lanier LL (1993) CD28? T lymphocytes: antigenic and functional properties. J Immunol 150: 1147?1159","journal-title":"J Immunol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/BF00915256","volume":"6","author":"S Gupta","year":"1986","unstructured":"Gupta S (1986) Abnormality of Leu2+7+ cells in acquired immune deficiency syndrome (AIDS), AIDS-related complex, and asymptomatic homosexuals. J Clin Immunol 6:502?509","journal-title":"J Clin Immunol"},{"key":"CR19","first-page":"16","volume":"69","author":"JW Gratama","year":"1987","unstructured":"Gratama JW, Kardol M, Naipal AM, Slats J, Den Ouden A, Stijnen T, D'Amaro J, The TH, Bruning JW (1987) The influence of cytomegalovirus carrier status on lymphocyte subsets and natural immunity. Clin Exp Immunol 69:16?24","journal-title":"Clin Exp Immunol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2249.1990.tb05395.x","volume":"82","author":"G Vanham","year":"1990","unstructured":"Vanham G, Kestens L, Gigase P, Colebunders R, Vandenbruaene M, Brijs L, Ceuppens JL (1990) Evidence for circulating activated cytotoxic T cells in HIV-infected subjects before the onset of opportunistic infections. Clin Exp Immunol 82: 3?9","journal-title":"Clin Exp Immunol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/art.1780360506","volume":"36","author":"A Dupuy d'Angeac","year":"1993","unstructured":"Dupuy d'Angeac A, Monier S, Jorgensen C, Gao Q, Travaglio-Encinoza A, Bologna C, Combe B, Sany J, R\u00e8me T (1993) Increased percentage of CD3+, CD57+ lymphocytes in patients with rheumatoid arthritis: correlation with duration of disease. Arthritis Rheum 36:608?612","journal-title":"Arthritis Rheum"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2249.1992.tb05826.x","volume":"90","author":"E Baumert","year":"1992","unstructured":"Baumert E, Wolff-Vorbeck G, Schlesier M, Peter HH (1992) Immunophenotypical alterations in a subset of patients with common variable immunodeficiency (CVID). Clin Exp Immunol 90:25?30","journal-title":"Clin Exp Immunol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1182\/blood.V82.1.192.bloodjournal821192","volume":"82","author":"JS Jaffe","year":"1993","unstructured":"Jaffe JS, Strober W, Sneller MC (1993) Functional abnormalities of CD8+ T cells define a unique subset of patients with common variable immunodeficiency. Blood 82:192?201","journal-title":"Blood"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00007890-198602000-00027","volume":"41","author":"SJ Forman","year":"1986","unstructured":"Forman SJ, Zaia JA, Wright C, Gallagher MT, Blume KG (1986) Increased Leu-7-positive T lymphocytes during cytomegalovirus infection following allogenic bone marrow transplantation for hematologic malignancies. Transplantation 41:268?271","journal-title":"Transplantation"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.4049\/jimmunol.137.7.2180","volume":"137","author":"E Leroy","year":"1986","unstructured":"Leroy E, Calvo CF, Divine M, Gourdin MF, Baujean F, Ben Aribia MH, Mishal Z, Vernant JP, Farcet JP, Senik A (1986) Persistence of T8+\/HNK-1+ suppressor lymphocytes in the blood of long-term surviving patients after allogenic bone marrow transplantation. J Immunol 137:2180?2190","journal-title":"J Immunol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1182\/blood.V74.5.1665.1665","volume":"74","author":"A Velardi","year":"1989","unstructured":"Velardi A, Varese P, Terenzi A, Dembecj C, Albi N, Grossi CE, Moretta L, Martelli NF, Grignani F, Mingari MC (1989) Lymphokine production by T-cell clones after human bone marrow transplantation. Blood 74:1665?1672","journal-title":"Blood"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-3083.1991.tb02519.x","volume":"33","author":"J Moller","year":"1991","unstructured":"Moller J, Dickmeiss E, Ryder LP, Jacobsen N, Svejgaard A (1991) Increased fequencies of the CD29 and CD57 markers and decreased frequency of CD45RA within CD4+ and CD8+ subsets after allogenic bone marrow transplantation in man. Scand J Immunol 33:499?504","journal-title":"Scand J Immunol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.4049\/jimmunol.136.5.1579","volume":"136","author":"JH Phillips","year":"1986","unstructured":"Phillips JH, Lanier LL (1986) Lectin-dependent and anti-CD3 induced cytotoxicity are preferentially mediated by peripheral blood cytotoxic T lymphocytes expressing Leu-7 antigen. J Immunol 136:1579?1585","journal-title":"J Immunol"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.4049\/jimmunol.139.11.3802","volume":"139","author":"BE Tomkinson","year":"1987","unstructured":"Tomkinson BE, Wagner DK, Nelson DL, Sullivan JL (1987) Activated lymphocytes during acute Epstein-Barr virus infection. J Immunol 139:3802?3807","journal-title":"J Immunol"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.4049\/jimmunol.143.7.2193","volume":"143","author":"P Joly","year":"1989","unstructured":"Joly P, Guillon JM, Mayaud C, Plata F, Theodorou I, Denis M, Debre P, Autran B (1989) Cell-mediated suppression of HIV-specific cytotoxic T lymphocytes. J Immunol 143:2193?2201","journal-title":"J Immunol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.4049\/jimmunol.141.11.3791","volume":"141","author":"J R\u00fcthlein","year":"1988","unstructured":"R\u00fcthlein J, James SP, Strober W (1988) Role of CD2 in activation and cytotoxic function of CD8\/Leu-7-positive T cells. J Immunol 141:3791?3797","journal-title":"J Immunol"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/intimm\/4.9.1049","volume":"4","author":"M Nakata","year":"1992","unstructured":"Nakata M, Kawasaki A, Azuma M, Tsuji K, Matsuda H, Shinkai Y, Yagita H, Okumura K (1992) Expression of perforin and cytolytic potential of human peripheral blood lymphocyte subpopulations. Int Immunol 4:1049?1054","journal-title":"Int Immunol"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF00919976","volume":"13","author":"S Zupo","year":"1993","unstructured":"Zupo S, Azzoni L, Massara R, D'Amato A, Perussia B, Ferrarini M (1993) Coexpression of Fc gamma receptor IIIA and interleukin-2 receptor beta chain by a subset of human CD3+\/CD8+\/CD11b+ lymphocytes. J Clin Immunol 13:228?236","journal-title":"J Clin Immunol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.4049\/jimmunol.149.4.1326","volume":"149","author":"HI McFarland","year":"1992","unstructured":"McFarland HI, Nahill SR, Maciaszek JW, Welsh RM (1992) CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection. J Immunol 149:1326?1333","journal-title":"J Immunol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1126\/science.3131876","volume":"240","author":"KA Smith","year":"1988","unstructured":"Smith KA (1988) Interleukin-2: inception, impact, and implications. Science 240:1169?1176","journal-title":"Science"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-4757-9182-2_5","volume":"336","author":"E Csernok","year":"1993","unstructured":"Csernok E, Schmitt WH, Ernst M, Bainton DF, Gross WL (1993) Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides. Adv Exp Med Biol 336:45?50","journal-title":"Adv Exp Med Biol"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-3083.1992.tb02953.x","volume":"36","author":"P Gane","year":"1992","unstructured":"Gane P, Fain O, Mansour I, Roquin H, Rouger P (1992) Expression of CD11b (Leu15) antigen on CD3+, CD4+, CD8+, CD16+ peripheral lymphocytes. Estimation of CD3+8+11b+ and CD3+4?8?11b+ T-cell subsets using a single laser flow cytometer. Scand J Immunol 36:395?404","journal-title":"Scand J Immunol"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00262300.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00262300\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00262300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T23:57:04Z","timestamp":1682812624000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00262300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["BF00262300"],"URL":"https:\/\/doi.org\/10.1007\/bf00262300","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}