{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:33:07Z","timestamp":1773419587176,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[1989,7]]},"DOI":"10.1007\/bf00263866","type":"journal-article","created":{"date-parts":[[2004,9,27]],"date-time":"2004-09-27T16:37:04Z","timestamp":1096303024000},"page":"308-313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Single breath N2 washout in papain-induced pulmonary emphysema"],"prefix":"10.1007","volume":"15","author":[{"given":"T.","family":"Hachenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wendt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Schreckenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Hermeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. -M.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lawin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00263866_CR1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1152\/jappl.1970.29.5.705","volume":"29","author":"E Agostoni","year":"1973","unstructured":"Agostoni E, Miserocchi G (1973) Vertical gradient of transpulmonary pressure with active and artificial lung expansion. J Appl Physiol 29:705\u2013712","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00000542-198311000-00006","volume":"59","author":"NA Bergman","year":"1983","unstructured":"Bergman NA, Tien YA (1983) Contribution of the closure of pulmonary units to impaired oxygenation during anesthesia. Anesthesiology 59:395\u2013401","journal-title":"Anesthesiology"},{"key":"BF00263866_CR3","first-page":"744","volume":"107","author":"AS Buist","year":"1973","unstructured":"Buist AS, Ross BB (1973) Predicted values for closing volumes using a modified single breath nitrogen test. Am Rev Respir Dis 107:744\u2013752","journal-title":"Am Rev Respir Dis"},{"key":"BF00263866_CR4","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1056\/NEJM197806082982303","volume":"298","author":"M Cosio","year":"1977","unstructured":"Cosio M, Ghezzo H, Hoog JC, Corbin R, Loveland M, Dosman J, Macklem PT (1977) The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med 298:1277\u20131281","journal-title":"N Engl J Med"},{"key":"BF00263866_CR5","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0034-5687(67)90057-6","volume":"2","author":"RE Dollfuss","year":"1968","unstructured":"Dollfuss RE, Milic-Emili J, Bazes DV (1968) Regional ventilation of the lung studied with boli of xenon 133. Respir Physiol 2:234\u2013246","journal-title":"Respir Physiol"},{"key":"BF00263866_CR6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/jappl.1949.2.6.283","volume":"38","author":"WS Fowler","year":"1949","unstructured":"Fowler WS (1949) Lung function studies III. Uneven pulmonary ventilation in normal subjects and in patients with pulmonary disease. J Appl Physiol 38:283\u2013299","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711170102","volume":"117","author":"JA Hayes","year":"1975","unstructured":"Hayes JA, Korthy A, Snider GL (1975) The pathology of elastase-induced panacinar emphysema in hamsters. J Pathol 117:1\u201314","journal-title":"J Pathol"},{"key":"BF00263866_CR8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/bja\/47.8.847","volume":"47","author":"G Hedenstierna","year":"1975","unstructured":"Hedenstierna G, McCarthy G (1975) The effect of anaesthesia and intermittent positive pressure ventilation with different frequencies on the anatomical and alveolar dead space. Br J Anaesth 47:847\u2013852","journal-title":"Br J Anaesth"},{"key":"BF00263866_CR9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1399-6576.1986.tb02393.x","volume":"30","author":"G Hedenstierna","year":"1986","unstructured":"Hedenstierna G, Tokics L, Strandberg A, Lundquist H, Brismar B (1986) Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis. Acta Anaesth Scand 30:183\u2013191","journal-title":"Acta Anaesth Scand"},{"key":"BF00263866_CR10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/jappl.1974.36.2.135","volume":"36","author":"RH Ingram","year":"1974","unstructured":"Ingram RH, O'Cain CF, Fridy WW (1974) Simultaneous quasi \u2014 static lung pressure \u2014 volume curves and \u201cclosing volume\u201d measurements. J Appl Physiol 36:135\u2013141","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR11","first-page":"1109","volume":"17","author":"JB Karlinsky","year":"1978","unstructured":"Karlinsky JB, Snider GL (1978) State of the art. Animal models of emphysema. Am Rev Respir Dis 17:1109\u20131133","journal-title":"Am Rev Respir Dis"},{"key":"BF00263866_CR12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1152\/jappl.1981.51.2.321","volume":"51","author":"T Klassen","year":"1981","unstructured":"Klassen T, Thurlbeck WM, Berend N (1981) Correlation between lung structure and function in a canine model of emphysema. J Appl Physiol 51:321\u2013326","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR13","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1152\/jappl.1977.43.6.983","volume":"43","author":"YL Lai","year":"1977","unstructured":"Lai YL, Rodarte JR, Hyatt RE (1977) Effect of body position on lung emptying in recumbent anesthetized dogs. J Appl Physiol 43:983\u2013987","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1152\/jappl.1975.39.2.235","volume":"39","author":"R Lemen","year":"1975","unstructured":"Lemen R, Jones G, Graf RD, Gowan G (1975) \u201cClosing volume\u201d changes in alloxan-induced pulmonary edema. J Appl Physiol 39:235\u2013241","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1152\/jappl.1982.52.1.141","volume":"52","author":"SA Likens","year":"1982","unstructured":"Likens SA, Mauderly JL (1982) Effect of elastase and histamine on single breath N2 washout in the rat. J Appl Physiol 52:141\u2013146","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1152\/jappl.1972.33.3.293","volume":"33","author":"V Marco","year":"1972","unstructured":"Marco V, Meranze DR, Yoshida M, Kimbel P (1972) Papain-induced experimental emphysema in the dog. J Appl Physiol 33:293\u2013299","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR17","first-page":"898","volume":"126","author":"PA Martorana","year":"1982","unstructured":"Martorana PA, W\u00fcsten B, van Even P, G\u00f6bel H, Schaper J (1982) A six-month study of the evolution of papain-induced empysema in the dog. Am Rev Respir Dis 126:898\u2013903","journal-title":"Am Rev Respir Dis"},{"key":"BF00263866_CR18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1152\/jappl.1973.35.1.25","volume":"35","author":"DE Niewoehner","year":"1973","unstructured":"Niewoehner DE, Kleinemann J (1973) Effects of experimental emphysema and bronchiolitis on lung mechanics and morphometry. J Appl Physiol 35:25\u201331","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR19","volume-title":"Applied respiratory physiology","author":"JF Nunn","year":"1987","unstructured":"Nunn JF (1987) Applied respiratory physiology, 3rd edn. Butterworth, London","edition":"3rd edn"},{"key":"BF00263866_CR20","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1152\/jappl.1969.26.6.738","volume":"26","author":"SS Park","year":"1969","unstructured":"Park SS, Goldring IP, Shim CS, Williams MH (1969) Mechanical properties of the lung in experimental pulmonary emphysema. J Appl Physiol 26:738\u2013744","journal-title":"J Appl Physiol"},{"key":"BF00263866_CR21","first-page":"778","volume":"102","author":"R Pushpakom","year":"1970","unstructured":"Pushpakom R, Hogg JC, Woolcock AJ, Angus AE, Macklem PE, Thurlbeck WM (1970) Experimental papain-induced emphysema in dogs. Am Rev Respir Dis 102:778\u2013789","journal-title":"Am Rev Respir Dis"},{"key":"BF00263866_CR22","unstructured":"Roth L, Daunderer M (1983) Giftliste. Giftige, gesundheits-sch\u00e4dliche, reizende und krebserregende Stoffe. IV, 12\u201313, Ergomed Verlagsgesellschaft"},{"key":"BF00263866_CR23","first-page":"36","volume":"35","author":"HU Spiegel","year":"1986","unstructured":"Spiegel HU, Bergermann M, Hauss J, Wendt M, Sch\u00f6nleben K (1986) Die hochdosierte Piritramidbasisan\u00e4sthesie in experimenteller An\u00e4sthesie und Chirurgie. Anaesthesist 35:36\u201342","journal-title":"Anaesthesist"},{"key":"BF00263866_CR24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1172\/JCI108630","volume":"59","author":"PD Wagner","year":"1977","unstructured":"Wagner PD, Dantzker RD, Dueck R, Clausen JL, West JB (1977) Ventilation \u2014 perfusion inequality in chronic obstructive pulmonary disease. J Clin Invest 59:203\u2013216","journal-title":"J Clin Invest"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00263866.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF00263866\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00263866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00263866.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T21:09:30Z","timestamp":1744146570000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF00263866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,7]]}},"alternative-id":["BF00263866"],"URL":"https:\/\/doi.org\/10.1007\/bf00263866","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7]]},"assertion":[{"value":"25 July 1988","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 1988","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}