{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:21:27Z","timestamp":1789694487868,"version":"4.0.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1989,11,1]],"date-time":"1989-11-01T00:00:00Z","timestamp":625881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochemistry"],"published-print":{"date-parts":[[1989,11]]},"DOI":"10.1007\/bf00266839","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T00:12:58Z","timestamp":1096416778000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Fine structure of neurons synthesizing vasoactive intestinal peptide in the human colon from patients with Hirschsprung's disease"],"prefix":"10.1007","volume":"93","author":[{"given":"T.","family":"Tsuto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. L.","family":"Obata-Tsuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","first-page":"283","volume":"23","author":"S Amano","year":"1981","unstructured":"Amano S (1981) Ultrastructural localization of vasoactive intestinal polypeptide (VIP) in Meissner's plexus of the human colon. Nihon Univ J Med 23:283?292","journal-title":"Nihon Univ J Med"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00548512","volume":"358","author":"HG Baumgarten","year":"1973","unstructured":"Baumgarten HG, Horstein AF, Stelzner F (1973) Nervous elements in the human colon of Hirschsprung's disease. (With comparative remarks on neuronal profiles in the normal human and monkey colon and sphincter ani internus). Virchows Arch [Pathol Anat] 358:113?136","journal-title":"Virchows Arch [Pathol Anat]"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0167-0115(85)90201-0","volume":"11","author":"I Berezin","year":"1985","unstructured":"Berezin I, Sheppard S, Daniel E, Yanaihara N (1985) Ultrastructural immunocytochemical distribution of VIP-like immunore-activity in dog ileum. Regul Pept 11:287?298","journal-title":"Regul Pept"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1126\/science.6176025","volume":"216","author":"KN Bitar","year":"1982","unstructured":"Bitar KN, Makhlouf GM (1982) Relaxation of isolated gastric smooth muscle cells by vasoactive intestinal peptide. Science 216:531?533","journal-title":"Science"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000212901","volume":"33","author":"F Erzs\ufffdbet","year":"1987","unstructured":"Erzs\ufffdbet F, P\ufffdnzes L (1987) Density of substance P, vasoactive intestinal polypeptide and somatostatin-containing nerve fibers in the ageing small intestine of the rats. Gerontology 33:341?348","journal-title":"Gerontology"},{"key":"CR6","series-title":"Advances in peptide hormone research series","first-page":"361","volume-title":"Vasoactive intestinal peptide","author":"J Fahrenkrug","year":"1982","unstructured":"Fahrenkrug J (1982) VIP as a neurotransmitter in the peripheral nervous system. In: Said SI (ed) Vasoactive intestinal peptide. (Advances in peptide hormone research series). Raven Press, New York, pp 361?372"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1113\/jphysiol.1978.sp012391","volume":"280","author":"J Fahrenkrug","year":"1978","unstructured":"Fahrenkrug J, Galbo H, Holst JJ, Schaffalitzky de Muckadell OB (1978) Influence of the autonomic nervous system on the release of vasoactive intestinal polypeptide from the porcine gastrointestinal tract. J Physiol (London) 280:405?422","journal-title":"J Physiol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/BF01965977","volume":"36","author":"T Furuta","year":"1980","unstructured":"Furuta T, Sakata K, Kunieda T, Kishimoto Y (1980) On the pathogenesis of intestinal aganglionosis. A consideration based on electron microscopic observations of experimental and clinical aganglionoses. Experientia 36:1073?1074","journal-title":"Experientia"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1136\/pgmj.48.562.471","volume":"48","author":"ER Howard","year":"1972","unstructured":"Howard ER (1972) Hirschsprung's disease: a review of the morphology and physiology. Postgrad Med J 48:471?477","journal-title":"Postgrad Med J"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1136\/gut.11.12.1007","volume":"11","author":"ER Howard","year":"1970","unstructured":"Howard ER, Garrett JR (1970a) Electron microscopy of myenteric nerves in Hirschsprung's disease and in normal bowel. Gut 11:1007?1014","journal-title":"Gut"},{"key":"CR11","first-page":"1264","volume":"63","author":"ER Howard","year":"1970","unstructured":"Howard ER, Garrett JR (1970b) Histochemistry and electron microscopy of rectum and colon in Hirschsprung's disease. Proc R Soc Med 63:1264?1266","journal-title":"Proc R Soc Med"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/BF01071907","volume":"21","author":"J Kachelhoffer","year":"1976","unstructured":"Kachelhoffer J, Mendel C, Dauchel J, Hohmatter D, Grenier JF (1976) The effects of VIP on intestinal motility. Study on ex vivo perfused isolated canine jejunal loops. Am J Dig Dis 21:957?962","journal-title":"Am J Dig Dis"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0361-9230(84)90059-5","volume":"12","author":"HL Obata-Tuso","year":"1984","unstructured":"Obata-Tuso HL, Tsuto T, Okamura H, Kubo T, Fukui K, Yanaihara N, Ibata Y (1984) The fine structures of the VIP-like immunoreactive neurons in the cat hypothalamus. Brain Res Bull 12:315?321","journal-title":"Brain Res Bull"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0016-5085(83)80077-8","volume":"85","author":"L Probert","year":"1983","unstructured":"Probert L, Mey JD, Polak JM (1983) Ultrastructural localization of four different neuropeptides within separate populations of p-type nerves in the guinea pig colon. Gastroenterology 85:1094?1104","journal-title":"Gastroenterology"},{"key":"CR15","first-page":"246","volume-title":"Gastrointestinal hormones","author":"SI Said","year":"1980","unstructured":"Said SI (1980) Vasoactive intestinal polypeptide (VIP): isolation, distribution, biological actions, structure-function relationships. In: Jerzy Glass GB (ed) Gastrointestinal hormones. Raven Press, New York, pp 246?273"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/18.5.315","volume":"18","author":"LA Sternberger","year":"1970","unstructured":"Sternberger LA, Hardy PH, Cuculis JJ, Meyer HG (1970) The unlabeled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-anti-horseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18:315?333","journal-title":"J Histochem Cytochem"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00692647","volume":"401","author":"T Taguchi","year":"1983","unstructured":"Taguchi T, Tanaka K, Ikeda K, Matsubayashi S, Yanaihara N (1983) Peptidergic innervation irregularities in Hirschsprung's disease. Virchows Arch [Pathol Anat] 401:223?235","journal-title":"Virchows Arch [Pathol Anat]"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3940(82)90092-1","volume":"34","author":"T Tsuto","year":"1982","unstructured":"Tsuto T, Okamura H, Fukui K, Obata HL, Terubayashi H, Iwai N, Majima S, Yanaihara N, Ibata Y (1982) An immunohistochemical investigation of vasoactive intestinal polypeptide in the colon of patients with Hirschsprung's disease. Neurosci Lett 34:57?62","journal-title":"Neurosci Lett"},{"key":"CR19","first-page":"250","volume":"39","author":"T Tsuto","year":"1984","unstructured":"Tsuto T, Obata-Tsuto H, Kawakami F, Fukui K, Iwai N, Majima S, Ibata Y (1984) New application of catecholamine fluorescence histochemistry using glyoxylic acid for diagnosis of Hirschsprung's disease by rectal biopsy. Kinderchirurgie 39:250?252","journal-title":"Kinderchirurgie"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0022-3468(85)80118-4","volume":"20","author":"T Tsuto","year":"1985","unstructured":"Tsuto T, Okamura H, Fukui K, Obata-Tsuto HL, Terubayashi H, Yanagihara J, Iwai N, Majima S, Yanaihara N, Ibata Y (1985) Immunohistochemical investigations of gut hormones in the colon of patients with Hirschsprung's disease. J Pediatr Surg 20:266?270","journal-title":"J Pediatr Surg"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0016-5085(77)80007-3","volume":"72","author":"N Yanaihara","year":"1977","unstructured":"Yanaihara N, Sakagami M, Sato H (1977) Immunological aspects of secretin, substance P and VIP. Gastroenterology 72:803?810","journal-title":"Gastroenterology"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2220\/biomedres.1.449","volume":"1","author":"C Yanaihara","year":"1980","unstructured":"Yanaihara C, Sakagami M, Mochizuki T (1980) Immunoreactive VIP (vasoactive intestinal polypeptide) in canine intestinal mucosa and muscle. Biomed Res 1:449?455","journal-title":"Biomed Res"}],"container-title":["Histochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00266839.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00266839\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00266839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T06:53:39Z","timestamp":1585896819000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00266839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["BF00266839"],"URL":"https:\/\/doi.org\/10.1007\/bf00266839","relation":{},"ISSN":["0301-5564","1432-119X"],"issn-type":[{"value":"0301-5564","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}