{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:51:41Z","timestamp":1785678701140,"version":"3.56.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochemistry"],"published-print":{"date-parts":[[1992,2]]},"DOI":"10.1007\/bf00267299","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T01:48:19Z","timestamp":1096422499000},"page":"105-110","source":"Crossref","is-referenced-by-count":14,"title":["Detection of gastrin and its messenger RNA in Zollinger-Ellison tumors by non-radioactive in situ hybridization and immunocytochemistry"],"prefix":"10.1007","volume":"97","author":[{"given":"L. -I.","family":"Larsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Hougaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00005792-196407000-00003","volume":"43","author":"HS Ballard","year":"1964","unstructured":"Ballard HS, Frame B, Harstock RJ (1964) Familial multiple endocrine adenoma-peptic ulcer complex. Medicine (Baltimore) 43:481?516","journal-title":"Medicine"},{"key":"CR2","volume-title":"Histochemistry","author":"T Barka","year":"1963","unstructured":"Barka T, Anderson P (1963) Histochemistry. Harper & Row, New York"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1073\/pnas.80.10.2866","volume":"80","author":"E Boel","year":"1983","unstructured":"Boel E, Vuust J, Norris K, Wind A, Rehfeld JF, Marcker KA (1983) Molecular cloning of human gastrin cDNA: evidence for evolution of gastrin by gene duplication. Proc Natl Acad Sci USA 80:2866?2869","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0300-5089(21)00074-2","volume":"3","author":"S Bonfils","year":"1974","unstructured":"Bonfils S, Bernades P (1974) Zollinger-Ellison syndrome: natural history and diagnosis. Clin Gastroenterol 3:539?557","journal-title":"Clin Gastroenterol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1136\/jcp.39.10.1066","volume":"39","author":"J Burns","year":"1986","unstructured":"Burns J, Redfern DRM, Esiri MM, McGee JOD (1986) Human and viral gene detection in routine paraffin embedded tissue by in situ hybridization with biotinylated probe: viral localization in herpes encephalitis. J Clin Pathol 39:1066?1073","journal-title":"J Clin Pathol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0046-8177(75)80109-2","volume":"6","author":"W Creutzfeldt","year":"1975","unstructured":"Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS (1975) Pathomorphologic, biochemical and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome). Hum Pathol 6:47?76","journal-title":"Hum Pathol"},{"key":"CR7","first-page":"589","volume-title":"Gut hormones","author":"W Creutzfeldt","year":"1978","unstructured":"Creutzfeldt W, Arnold R, Frerichs H (1978) Insulinomas and gastrinomas. In: Bloom SR (ed) Gut hormones. Churchill-Livingstone, Edinburgh, pp 589?598"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/37.1.2642295","volume":"37","author":"RW Dirks","year":"1989","unstructured":"Dirks RW, Raap AK, Minnen J van, Vrengdenhil E, Smit AB, Ploeg M van der (1989) Detection of mRNA molecules coding for neuropeptide hormones of the pond snail Lymnea stagnalis by radioactive and non-radioactive in situ hybridization. A model study for mRNA detection. J Histochem Cytochem 37:7?14","journal-title":"J Histochem Cytochem"},{"key":"CR9","first-page":"2","volume":"3","author":"S Fitzpatrick-McElligott","year":"1988","unstructured":"Fitzpatrick-McElligott S, Lewis ME, Tyler M, Baldino F Jr, Davis LG (1988) In situ hybridization with radiolabeled, synthetic oligodeoxynucleotide probes. DuPont Biotech Update 3, pp 2?3, 16","journal-title":"DuPont Biotech Update"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1210\/mend-1-4-306","volume":"1","author":"PJ Fuller","year":"1987","unstructured":"Fuller PJ, Stone DL, Brand SJ (1987) Molecular cloning and sequencing of a rat preprogastrin complementary deoxyribonucleic acid. Mol Endocrinol 1:306?311","journal-title":"Mol Endocrinol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/14.4.291","volume":"14","author":"RC Graham","year":"1966","unstructured":"Graham RC, Karnovsky MJ (1966) The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: Ultrastructural cytochemistry by a new technique. J Histochem Cytochem 14:291?302","journal-title":"J Histochem Cytochem"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0046-8177(75)80097-9","volume":"6","author":"S Hammar","year":"1975","unstructured":"Hammar S, Sale G (1975) Multiple hormone producing islet cell carcinomas of the pancreas. Hum Pathol 6:349?362","journal-title":"Hum Pathol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0169-5002(90)90253-I","volume":"6","author":"FR Hirsch","year":"1990","unstructured":"Hirsch FR, Holst JJ, Larsson L-I (1990) Immunocytochemical demonstration of bombesin immunoreactivity in small cell carcinoma of the lung. A methodological study and review of the literature. Lung Cancer 6:1?8","journal-title":"Lung Cancer"},{"key":"CR14","first-page":"293","volume":"14","author":"L-I Larsson","year":"1979","unstructured":"Larsson L-I (1979) Pathology of the gastrin cell. Pathol Ann 14:293?316","journal-title":"Pathol Ann"},{"key":"CR15","first-page":"527","volume-title":"Neuro-histochemistry: modern methods and applications","author":"L-I Larsson","year":"1986","unstructured":"Larsson L-I (1986) Histochemistry of gastrin cells. In: Panula P, P\u00e4iv\u00e4rinta H, Soinila S (eds) Neuro-histochemistry: modern methods and applications. Liss, New York, pp 527?567"},{"key":"CR16","volume-title":"Immunocytochemistry, Theory and Practice","author":"L-I Larsson","year":"1988","unstructured":"Larsson L-I (1988) Immunocytochemistry, Theory and Practice. CRC Press Inc., Boca Raton, Florida"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/BF01845792","volume":"21","author":"L-I Larsson","year":"1989","unstructured":"Larsson L-I (1989) In situ hybridization of messenger RNA sequences. Histochem J 21:435?440","journal-title":"Histochem J"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF00315849","volume":"93","author":"L-I Larsson","year":"1990","unstructured":"Larsson L-I, Hougaard DM (1990) Optimization of non-radioactive in situ hybridization: image analysis of varying pretreatment, hybridization and probe labelling conditions. Histochemistry 93:347?354","journal-title":"Histochemistry"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00315993","volume":"96","author":"L-I Larsson","year":"1991","unstructured":"Larsson L-I, Hougaard DM (1991) Combined non-radioactive detection of peptide hormones and their mRNA's in endocrine cells. Histochemistry 96:375?380","journal-title":"Histochemistry"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1177\/25.12.925341","volume":"25","author":"L-I Larsson","year":"1977","unstructured":"Larsson L-I, Rehfeld JF (1977a) Characterization of antral gastrin cells with region-specific antisera. J Histochem Cytochem 25:1317?1321","journal-title":"J Histochem Cytochem"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/269335a0","volume":"269","author":"L-I Larsson","year":"1977","unstructured":"Larsson L-I, Rehfeld JF (1977b) Evidence for a common evolutionary origin of gastrin and cholecystokinin. Nature 269:335?338","journal-title":"Nature"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00489913","volume":"89","author":"L-I Larsson","year":"1988","unstructured":"Larsson L-I, Christensen T, Dalb\u00f8ge H (1988) Detection of proopiomelanocortin mRNA by in situ hybridization, using a biotinylated oligodeoxynucleotide probe and avidin-alkaline phosphatase histochemistry. Histochemistry 89:109?116","journal-title":"Histochemistry"},{"key":"CR23","first-page":"271","volume":"79","author":"L-I Larsson","year":"1975","unstructured":"Larsson L-I, Grimelius L, H\u00bbkanson R, Rehfeld JF, Stadil F, Holst J, Angervall L, Sundler F (1975) Mixed endocrine pancreatic tumours producing several peptide hormones. Am J Pathol 79:271?280","journal-title":"Am J Pathol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00266769","volume":"95","author":"L-I Larsson","year":"1991","unstructured":"Larsson L-I, Traasdahl B, Hougaard DM (1991) Quantitative non-radioactive in situ hybridization. Model studies and studies on pituitary proopiomelanocortin cells after adrenalectomy. Histochemistry 95:209?215","journal-title":"Histochemistry"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1073\/pnas.80.13.4045","volume":"80","author":"JJ Leary","year":"1983","unstructured":"Leary JJ, Brigati DJ, Ward D (1983) Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized in nitrocellulose: bioblots. Proc Natl Acad Sci USA 80:4045?4049","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00000478-199001000-00004","volume":"14","author":"RV Lloyd","year":"1990","unstructured":"Lloyd RV, Jin L, Fields K (1990) Detection of chromogranins A and B in endocrine tissues with radioactive and biotinylated oligonucleotide probes. Am J Surg Pathol 14:35?43","journal-title":"Am J Surg Pathol"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1083\/jcb.103.5.2025","volume":"103","author":"OD Madsen","year":"1986","unstructured":"Madsen OD, Larsson L-I, Rehfeld JF, Schwartz TW, Lernmark \u00c5, Labrecque AD, Steiner DF (1986) Cloned cell lines from a transplantable islet cell tumor are heterogenous and express cholecystokinin in addition to islet hormones. J Cell Biol 103:2025?2034","journal-title":"J Cell Biol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1073\/pnas.85.18.6652","volume":"85","author":"OD Madsen","year":"1988","unstructured":"Madsen OD, Andersen LC, Michelsen B, Owerbach D, Larsson L-I, Lernmark \u00c5, Steiner DF (1988) Tissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines during passage in vivo. Proc Natl Acad Sci USA 85:6652?6656","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR29","first-page":"25","volume-title":"Techniques in immunocytochemistry, vol 3","author":"DY Mason","year":"1985","unstructured":"Mason DY (1985) Immunocytochemical labeling of monoclonal antibodies by the APAAP immunoalkaline phosphatase technique. In: Bullock GB, Petrusz P (eds) Techniques in immunocytochemistry, vol 3. Academic Press, New York, pp 25?42"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0196-9781(82)90172-3","volume":"3","author":"MH Schaffer","year":"1982","unstructured":"Schaffer MH, Agarwal KL, Noyes BE (1982) Rat gastrin's amino acid sequence determined from the nucleotide sequence of the mRNA. Peptides 3:693?696","journal-title":"Peptides"},{"key":"CR31","first-page":"119","volume-title":"Progress in surgical pathology, vol I","author":"E Solcia","year":"1980","unstructured":"Solcia E, Capella C, Buffa R, Frigerio B, Fiocca R (1980) Pathology of the Zollinger-Ellison syndrome. In: Fenoglio CM (ed) Progress in surgical pathology, vol I. Memon Publ Co, New York, pp 119?133"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/38.3.1689343","volume":"38","author":"CA Ziomek","year":"1990","unstructured":"Ziomek CA, Lepire ML, Torres I (1990) A highly fluorescent simultaneous azo dye technique for demonstration of nonspecific alkaline phosphatase activity. J Histochem Cytochem 38:437?442","journal-title":"J Histochem Cytochem"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/00000658-195510000-00015","volume":"142","author":"RM Zollinger","year":"1955","unstructured":"Zollinger RM, Ellison EH (1955) Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 142:709?728","journal-title":"Ann Surg"}],"container-title":["Histochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00267299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00267299\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00267299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T01:13:09Z","timestamp":1624669989000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00267299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["BF00267299"],"URL":"https:\/\/doi.org\/10.1007\/bf00267299","relation":{},"ISSN":["0301-5564","1432-119X"],"issn-type":[{"value":"0301-5564","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}