{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:28:34Z","timestamp":1760027314662},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[1993,3]]},"DOI":"10.1007\/bf00271365","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T03:48:56Z","timestamp":1102650536000},"page":"243-246","source":"Crossref","is-referenced-by-count":18,"title":["Plasma concentration ? effect relationship of metoprolol during and after pregnancy"],"prefix":"10.1007","volume":"44","author":[{"given":"S.","family":"H\ufffdgstedt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"5","key":"CR1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-0773.1975.tb03329.x","volume":"36","author":"KO Borg","year":"1975","unstructured":"Borg KO, Carlsson E, Hoffmann K-J, J\u00f6nsson T-E, Thorin H, Wallin B (1975) Metabolism of metoprolol-(3H) in man, the dog and the rat. Acta Pharmacol Toxicol 36 [Suppl 5]: 125?135","journal-title":"Acta Pharmacol Toxicol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2165\/00003088-197904010-00005","volume":"4","author":"M Dam","year":"1977","unstructured":"Dam M, Christiansen J, Munch O, Mygind KI (1977) Antiepileptic drugs: metabolism in pregnancy. Clin Pharmacokinet 4: 53?62","journal-title":"Clin Pharmacokinet"},{"issue":"5","key":"CR3","first-page":"134","volume":"36","author":"M Ervik","year":"1975","unstructured":"Ervik M (1975) Quantitative determination of metoprolol in plasma and urine by gas chromatography. Acta Pharmacol Toxicol 36 [Suppl 5]: 134?144","journal-title":"Acta Pharmacol Toxicol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/bmj.1.6178.1591","volume":"I","author":"EDM Gallery","year":"1979","unstructured":"Gallery EDM, Saunders DM, Hunyor SN, Gyory AZ (1979) Randomized comparison of methyldopa and oxprenolol for treatment of hypertension in pregnancy. BMJ I: 1591?1594","journal-title":"BMJ"},{"key":"CR5","unstructured":"Gugler R, Christ R, Raczinski H, H\u00f6ffgen K, Bodem G (1979) Pharmacokinetic and pharmacodynamic comparison of three beta-adrenoceptor blocking drugs. Naunyn Schmiedebergs Arch Pharmacol 307: R76 (303)"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00613820","volume":"24","author":"S H\u00f6gstedt","year":"1983","unstructured":"H\u00f6gstedt S, Lindberg B, Rane A (1983) Increased oral clearance of metoprolol in pregnancy. Eur J Clin Pharmacol 24: 217?220","journal-title":"Eur J Clin Pharmacol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/clpt.1985.114","volume":"37","author":"S H\u00f6gstedt","year":"1985","unstructured":"H\u00f6gstedt S, Lindberg B, Peng DR, Reg\u00bbrdh C-G, Rane A (1985) Pregnancy-induced increase in metoprolol metabolism. Clin Pharmacol Ther 37: 688?692","journal-title":"Clin Pharmacol Ther"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/00016348509156729","volume":"64","author":"S H\u00f6gstedt","year":"1985","unstructured":"H\u00f6gstedt S, Lindeberg S, Axelsson O, Lindmark G, Rane A, Sandstr\u00f6m B, Lindberg BS (1985) A prospective controlled trial of metoprolol-hydralazine treatment in hypertension during pregnancy. Acta Obstet Gynecol Scand 64: 505?510","journal-title":"Acta Obstet Gynecol Scand"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1600-0773.1990.tb00697.x","volume":"66","author":"S H\u00f6gstedt","year":"1990","unstructured":"H\u00f6gstedt S, Lindberg B, Reg\u00bbrdh C-G, Mostr\u00f6m U, Rane A (1990) The Rhesus monkey as a model for studies of pregnancy-induced changes in metoprolol metabolism. Pharmacol Toxicol 66: 32?36","journal-title":"Pharmacol Toxicol"},{"key":"CR10","volume-title":"The physiology of human pregnancy","author":"FE Hytten","year":"1971","unstructured":"Hytten FE, Leitch I (1971) The physiology of human pregnancy. 2nd edition. Oxford: Blackwell Scientific Publications","edition":"2nd edition"},{"issue":"5","key":"CR11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1600-0773.1975.tb03320.x","volume":"36","author":"G Johnsson","year":"1975","unstructured":"Johnsson G, Reg\u00bbrdh C-G, S\u00f6lvell L (1975) Combined pharmacokinetic and pharmacodynamic studies in man of the adrenergic-receptor antagonist metoprolol. Acta Pharmacol Toxicol 36 [Suppl 5]: 31?44","journal-title":"Acta Pharmacol Toxicol"},{"key":"CR12","doi-asserted-by":"crossref","unstructured":"Kjellmer I, Dagbjartsson A, Hrbek K, Karlsson K, Ros\u00e9n KG (1984) Maternal beta-adrenoreceptor blockade reduces fetal tolerance to asphyxia. A study in pregnant sheep. Acta Obstet Gynecol Scand [Suppl 118]: 75?80","DOI":"10.3109\/00016348409157128"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.2165\/00003088-197702030-00002","volume":"2","author":"B Krauer","year":"1977","unstructured":"Krauer B, Krauer F (1977) Drug kinetics in pregnancy. Clin Pharmacokinet 2: 1671?1681","journal-title":"Clin Pharmacokinet"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1212\/WNL.27.2.128","volume":"27","author":"CM Lander","year":"1977","unstructured":"Lander CM, Edwards WE, Eadie MJ, Tyrer JH (1977) Plasma anticonvulsant concentrations during pregnancy. Neurology 27: 128?131","journal-title":"Neurology"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/BF00635903","volume":"29","author":"S Lyren\u00e4s","year":"1986","unstructured":"Lyren\u00e4s S, Grahn\u00e9n A, Lindberg B, Lindstr\u00f6m B, L\u00f6nnerholm G (1986) Pharmacokinetics of terbutaline during pregnancy. Eur J Clin Pharmacol 29: 619?623","journal-title":"Eur J Clin Pharmacol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2165\/00003088-198207060-00003","volume":"7","author":"H Nau","year":"1982","unstructured":"Nau H, Kuhnz W, Egger H-J, Rating D, Helge H (1982) Anticonvulsants during pregnancy and lactation: Transplacental maternal and neonatal pharmacokinetics. Clin Pharmacokinet 7: 508?543","journal-title":"Clin Pharmacokinet"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00609896","volume":"24","author":"MF O'Hare","year":"1983","unstructured":"O'Hare MF, Leahey W, Murnaghan GA, McDevitt DG (1983) Pharmacokinetics of sotalol during pregnancy. Eur J Clin Pharmacol 24: 521?524","journal-title":"Eur J Clin Pharmacol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/infdis\/136.3.370","volume":"136","author":"A Philipsson","year":"1977","unstructured":"Philipsson A (1977) Pharmacokinetics of ampicillin during pregnancy. J Infect Dis 136: 370?376","journal-title":"J Infect Dis"},{"key":"CR19","first-page":"774","volume":"228","author":"A Rane","year":"1984","unstructured":"Rane A, H\u00f6gstedt S, Lindberg B, Reg\u00bbrdh C-G, Jorulf H (1984) Comparison of different clearance estimates for metoprolol in the Rhesus monkey. J Pharmacol Exp Ther 228: 774?778","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"CR20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0773.1975.tb03321.x","volume":"36","author":"C-G Reg\u00bbrdh","year":"1975","unstructured":"Reg\u00bbrdh C-G, Johnsson G, Jord\u00f6 L, S\u00f6lvell L (1975) Comparative bioavailability and effect studies in metoprolol administered as ordinary and slow-release tablets in single and multiple doses. Acta Pharmacol Toxicol 36 [Suppl 5]: 45?58","journal-title":"Acta Pharmacol Toxicol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/01.RES.19.2.400","volume":"21","author":"BF Robinson","year":"1966","unstructured":"Robinson BF, Epstein SE, Beiser GD, Braunwald E (1966) Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ Res 21: 400?411","journal-title":"Circ Res"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2125.1983.tb01531.x","volume":"15","author":"PC Rubin","year":"1983","unstructured":"Rubin PC, Butters L, Kelman AW, Fitzsimons C, Reid JL (1983) Labetalol disposition and concentration-effect relationship during pregnancy. Br J Clin Pharmacol 15: 465?470","journal-title":"Br J Clin Pharmacol"},{"issue":"2&3","key":"CR23","first-page":"141","volume":"B4","author":"K Wichman","year":"1985","unstructured":"Wichman K, Karlberg BE, Ryd\u00e9n G (1985) Metoprolol in the treatment of mild to moderate hypertension in pregnancy ? effects on the mother. Clin Exper Hypertens Preg B4 (2&3): 141?156","journal-title":"Clin Exper Hypertens Preg"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00271365.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00271365\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00271365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T15:47:41Z","timestamp":1705420061000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00271365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["BF00271365"],"URL":"https:\/\/doi.org\/10.1007\/bf00271365","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}