{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T15:13:13Z","timestamp":1786806793196,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1987,8,1]],"date-time":"1987-08-01T00:00:00Z","timestamp":554774400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[1987,8]]},"DOI":"10.1007\/bf00272442","type":"journal-article","created":{"date-parts":[[2004,10,4]],"date-time":"2004-10-04T04:17:53Z","timestamp":1096863473000},"page":"344-347","source":"Crossref","is-referenced-by-count":9,"title":["Frequency of the fragile X syndrome in institutionalized mentally retarded females in Japan"],"prefix":"10.1007","volume":"76","author":[{"given":"T.","family":"Arinami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF00279092","volume":"73","author":"T Arinami","year":"1986","unstructured":"Arinami T, Kondo I, Nakajima S (1986) Frequency of the fragile X syndrome in Japanese mentally retarded males. Hum Genet 73: 309?312","journal-title":"Hum Genet"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/jmg.21.5.373","volume":"21","author":"M Fitchett","year":"1984","unstructured":"Fitchett M, Seabright M (1984) Detected X chromosome in patients with fra(X) syndrome. J Med Genet 21:373","journal-title":"J Med Genet"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/BF00303019","volume":"60","author":"U Froster-Iskenius","year":"1982","unstructured":"Froster-Iskenius U, Schwinger E, Weigert M, Fonatsch C (1982) Replication pattern in XXY cells with fra(X). Hum Genet 60:278?280","journal-title":"Hum Genet"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ajmg.1320230110","volume":"23","author":"JP Fryns","year":"1986","unstructured":"Fryns JP (1986) The female and the fragile X. A study of 144 obligate female carriers. Am J Med Genet 23:157?169","journal-title":"Am J Med Genet"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1399-0004.1984.tb01086.x","volume":"26","author":"JP Fryns","year":"1984","unstructured":"Fryns JP, Kleczkowska A, Wolfs I, Van den Berghe H (1984) Klinefelter syndrome and two fragile X chromosomes. Clin Genet 26:445?447","journal-title":"Clin Genet"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/BF00333538","volume":"62","author":"RT Howell","year":"1982","unstructured":"Howell RT, McDermott A (1982) Replication of the fragile X chromosome fra(X) (q27) in three heterozygous females. Hum Genet 62:282?284","journal-title":"Hum Genet"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ajmg.1320070408","volume":"7","author":"PA Jacobs","year":"1980","unstructured":"Jacobs PA, Glover TW, Mayer M, Fox P, Gerrard JW, Dunn HG, Herbst DS (1980) X-linked mental retardation: a study of 7 families. Am J Med Genet 7:471?489","journal-title":"Am J Med Genet"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ajmg.1320230150","volume":"23","author":"PA Jacobs","year":"1986","unstructured":"Jacobs PA, Mayer M, Abruzzo MA (1986) Studies of the fragile (X) syndrome in populations of mentally retarded individuals in Hawaii. Am J Med Genet 23:567?572","journal-title":"Am J Med Genet"},{"key":"CR9","first-page":"640","volume":"36","author":"JH Knoll","year":"1984","unstructured":"Knoll JH, Chudley AE, Gerrard JW (1984) Fragile (X) X-linked mental retardation. II. Frequency and replication pattern of fragile (X) (q28) in heterozygotes. Am J Hum Genet 36:640?645","journal-title":"Am J Hum Genet"},{"key":"CR10","first-page":"231","volume":"21","author":"HA Lubs","year":"1969","unstructured":"Lubs HA (1969) A marker X chromosome. Am J Hum Genet 21: 231?244","journal-title":"Am J Hum Genet"},{"key":"CR11","first-page":"1418","volume-title":"Mendelian inheritance in man","author":"VA McKusick","year":"1986","unstructured":"McKusick VA (1986) 30955: Mental retardation, X-linked, associated with mar Xq28 (X-linked mental retardation and macroorchidism; Marker X syndrome; Fragile X syndrome; FRAXA; Martin-Bell syndrome). In: Mendelian inheritance in man, 7th edn. Johns Hopkins University Press, Baltimore, pp 1418?1421","edition":"7th edn"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/jnnp.6.3-4.154","volume":"6","author":"JP Martin","year":"1943","unstructured":"Martin JP, Bell J (1943) A pedigree of mental defect showing sexlinkage. J Neurol Psychiatry 6:154?157","journal-title":"J Neurol Psychiatry"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF00293025","volume":"69","author":"M Mayer","year":"1985","unstructured":"Mayer M, Abruzzo MA, Jacobs PJ, Yee SC (1985) A cytogenetic study of a population of retarded females with special reference to the fragile (X) syndrome. Hum Genet 69:206?208","journal-title":"Hum Genet"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00278849","volume":"59","author":"KB Nielsen","year":"1981","unstructured":"Nielsen KB, Tommerup N, Poulsen H, Mikkelsen M (1981) X-linked mental retardation with fragile X. A pedigree showing transmission by apparently unaffected males and partial expression in female carriers. Hum Genet 59:23?25","journal-title":"Hum Genet"},{"key":"CR15","first-page":"373","volume":"21","author":"KB Nielsen","year":"1983","unstructured":"Nielsen KB, Tommerup N, Poulsen H, Jacobsen P, Beck B, Mikkelsen M (1983) Carrier detection and X inactivation studies in patients with fragile X syndrome. J Med Genet 21:373","journal-title":"J Med Genet"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF00287638","volume":"66","author":"J Paul","year":"1984","unstructured":"Paul J, Froster-Iskenius V, Moje W, Schwinger E (1984) Heterozygous female carriers of the marker-X chromosome: IQ estimation and replication status fra(X)(Q). Hum Genet 66:344?346","journal-title":"Hum Genet"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1192\/bjp.148.6.655","volume":"148","author":"DA Primrose","year":"1986","unstructured":"Primrose DA, El-Matmati R, Boyd E, Gosden C, Newton M (1986) Prevalence of the fragile X syndrome in an institution for the mentally handicapped. Br J Psychiatr 148:655?657","journal-title":"Br J Psychiatr"},{"key":"CR18","first-page":"253","volume":"25","author":"EW Richards","year":"1981","unstructured":"Richards EW, Sylvester PE, Brooker C (1981) Fragile X-linked mental retardation: the Martin-Bell syndrome. J Ment Defic Res 25: 253?256","journal-title":"J Ment Defic Res"},{"key":"CR19","first-page":"452","volume":"34","author":"GR Sutherland","year":"1982","unstructured":"Sutherland GR (1982) Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites. Am J Hum Genet 34:452?458","journal-title":"Am J Hum Genet"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/jmg.22.2.85","volume":"22","author":"E Tuckerman","year":"1985","unstructured":"Tuckerman E, Webb T, Bundey SE (1985) Frequency and replication status of the fragile X, fra(X)(q27-28), in a pair of monozygotic twins of markedly differing intelligence. J Med Genet 22:85?91","journal-title":"J Med Genet"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/jmg.23.5.407","volume":"23","author":"E Tuckerman","year":"1986","unstructured":"Tuckerman E, Webb T, Thake A (1986) Replication status of fragile X(q27.3) in 13 female heterozygotes. J Med Genet 23:407?410","journal-title":"J Med Genet"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4615-8342-4_2","volume":"13","author":"G Turner","year":"1983","unstructured":"Turner G, Jacobs P (1983) Marker (X)-linked mental retardation. Adv Hum Genet 13:83?110","journal-title":"Adv Hum Genet"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1056\/NEJM198009183031202","volume":"303","author":"G Turner","year":"1980","unstructured":"Turner G, Brookwell R, Daniel A, Selikowitz M, Zilibowitz M (1980) Heterozygous expression of X-linked mental retardation and X-chromosome marker fra(X)(q27). N Engl J Med 303:662?664","journal-title":"N Engl J Med"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1056\/NEJM198609043151002","volume":"315","author":"G Turner","year":"1986","unstructured":"Turner G, Robinson H, Laing S, Purvis-Smith S (1986) Preventive screening for the fragile X syndrome. N Engl J Med 315:607?609","journal-title":"N Engl J Med"},{"key":"CR25","first-page":"286","volume":"34","author":"IA Uchida","year":"1982","unstructured":"Uchida IA, Joyce EM (1982) Activity of the fragile X in heterozygous carriers. Am J Hum Genet 34:286?293","journal-title":"Am J Hum Genet"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/jmg.23.5.396","volume":"23","author":"TP Webb","year":"1986","unstructured":"Webb TP, Bundey S, Thake A, Todd J (1986) The frequency of the fragile X chromosome among schoolchildren in Coventry. J Med Genet 23:396?399","journal-title":"J Med Genet"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00272442.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00272442\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00272442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:22:34Z","timestamp":1554319354000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00272442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,8]]}},"alternative-id":["BF00272442"],"URL":"https:\/\/doi.org\/10.1007\/bf00272442","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,8]]}}}