{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:44:25Z","timestamp":1768283065688,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[1985,3]]},"DOI":"10.1007\/bf00273867","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T17:07:38Z","timestamp":1644253658000},"page":"172-175","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy-associated changes in the endocrine pancreas of normoglycaemic streptozotocin-treated Wistar rats"],"prefix":"10.1007","volume":"28","author":[{"given":"B.","family":"Ziegler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lucke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Besch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. -J.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00273867_CR1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/00016346009159930","volume":"39","author":"B Hellman","year":"1960","unstructured":"Hellman B (1960) The islets of Langerhans in the rat during pregnancy and lactation with special reference to the changes in the B\/A cell ratio. Acta Obstet Gynecol Scand 39: 331\u2013342","journal-title":"Acta Obstet Gynecol Scand"},{"key":"BF00273867_CR2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0002-9378(16)33642-0","volume":"118","author":"FA Van Assche","year":"1974","unstructured":"Van Assche FA (1974) Quantitative morphologic and histoenzymatic study of the endocrine pancreas in non-pregnant and pregnant rats. Am J Obstet Gynecol 118: 39\u201341","journal-title":"Am J Obstet Gynecol"},{"key":"BF00273867_CR3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/262501a0","volume":"262","author":"AJ Bone","year":"1976","unstructured":"Bone AJ, Taylor KW (1976) Metabolic adaptation to pregnancy shown by increased biosynthesis of insulin in islets of Langerhans isolated from pregnant rats. Nature 262: 501\u2013502","journal-title":"Nature"},{"key":"BF00273867_CR4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1677\/joe.0.0540317","volume":"54","author":"JC Green","year":"1972","unstructured":"Green JC, Taylor KW (1972) Effects of pregnancy in the rat on the size and insulin secretory response of the islets of Langerhans. J Endocrinol 54: 317\u2013325","journal-title":"J Endocrinol"},{"key":"BF00273867_CR5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF01921949","volume":"34","author":"B Ziegler","year":"1978","unstructured":"Ziegler B, Ziegler M, Fiedler H (1978) Effects of pregnancy on the glucose-induced insulin release from cultivated pancreatic islets of the rat. Experienta 34: 138\u2013139","journal-title":"Experienta"},{"key":"BF00273867_CR6","first-page":"792","volume":"6","author":"SSC Yen","year":"1971","unstructured":"Yen SSC, Rsai CC, Vela P (1971) Gestational diabetogenesis quantitative analyses of the glucose-insulin relationship between normal pregnancy and pregnancy with gestational diabetes. Am J Obstet Gynecol 6: 792\u2013800","journal-title":"Am J Obstet Gynecol"},{"key":"BF00273867_CR7","first-page":"373","volume":"5","author":"G Marynissen","year":"1983","unstructured":"Marynissen G, Aerts L, Van Assche FA (1983) The endocrine pancreas during pregnancy and lactation in the rat. J Dev Physiol 5: 373\u2013381","journal-title":"J Dev Physiol"},{"key":"BF00273867_CR8","first-page":"308","volume":"71","author":"HJ Hahn","year":"1978","unstructured":"Hahn HJ (1978) Die isolierte Langerhans'sche Insel, ein Modell zur Untersuchung der Insulinsekretion in vitro. Endokrinologie 71: 308\u2013324","journal-title":"Endokrinologie"},{"key":"BF00273867_CR9","first-page":"91","volume":"15","author":"D Gottschling","year":"1974","unstructured":"Gottschling D, Ziegler M, Wilke W, Michael R (1974) Radioimmunoassay von Plasmainsulin. Methodenkritische Untersuchungen. Radiobiol Radiother 15: 91\u201397","journal-title":"Radiobiol Radiother"},{"key":"BF00273867_CR10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3109\/10520295909114654","volume":"34","author":"PE Lacy","year":"1959","unstructured":"Lacy PE, Davies J (1959) Demonstration of insulin in mammalian pancreas by the fluorescent antibody method. Stain Technol 34: 85\u201390","journal-title":"Stain Technol"},{"key":"BF00273867_CR11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0074-7696(08)61637-X","volume":"26","author":"ER Weibel","year":"1969","unstructured":"Weibel ER (1969) Stereological principles for morphometry in electron microscopic cytology. Int Rev Cytol 26: 235\u2013302","journal-title":"Int Rev Cytol"},{"key":"BF00273867_CR12","first-page":"167","volume":"44","author":"S Lucke","year":"1985","unstructured":"Lucke S, Ziegler B, Weidlich K, Barowski U, Besch W, Hahn HJ (1985) The effect of subdiabetogenic streptozotocin doses on rat beta cell volume and functions. Biomed Biochim Acta 44: 167\u2013171","journal-title":"Biomed Biochim Acta"},{"key":"BF00273867_CR13","first-page":"1171","volume":"41","author":"B Ziegler","year":"1982","unstructured":"Ziegler B, Kohnert KD, Noack S, Hahn HJ (1982) Effects of 3-isobutyl-1-methylxanthine on secretory response, cAMP accumulation and DNA synthesis of islets from postnatal and adult Wistar rats. Acta Biol Med Germ 41: 1171\u20131177","journal-title":"Acta Biol Med Germ"},{"key":"BF00273867_CR14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0003-2697(71)90476-3","volume":"39","author":"RT Hinegardner","year":"1971","unstructured":"Hinegardner RT (1971) An improved fluorometric assay for DNA. Anal Biochem 39: 197\u2013201","journal-title":"Anal Biochem"},{"key":"BF00273867_CR15","first-page":"79","volume":"15","author":"M Ziegler","year":"1974","unstructured":"Ziegler M, Michael R, Stein HH, Klatt D (1974) Radioimmunoassay von Pankreasglukagon isolierter Langerhans'scher Ratteninseln nach dem Prinzip der R\u00fccktitration. Radiobiol Radiother 15: 79\u201384","journal-title":"Radiobiol Radiother"},{"key":"BF00273867_CR16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2337\/diab.30.7.590","volume":"30","author":"GC Weir","year":"1981","unstructured":"Weir GC, Clore ET, Zmachinski CJ, Bonner-Weir S (1981) Islet secretion in a new experimental model for non-insulin-dependent diabetes. Diabetes 30: 590\u2013595","journal-title":"Diabetes"},{"key":"BF00273867_CR17","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI110910","volume":"71","author":"S Bonner-Weir","year":"1983","unstructured":"Bonner-Weir S, Trent DF, Weir GC (1983) Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 71: 1544\u20131552","journal-title":"J Clin Invest"},{"key":"BF00273867_CR18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/B978-0-08-015844-0.50008-0","volume-title":"The structure and metabolism of the pancreatic islets","author":"J Logothetopoulos","year":"1970","unstructured":"Logothetopoulos J, Brodsky G, Kern MF (1970) Islet cell proliferation in experimental and genetic diabetes. In: Falkmer S, Hellman B, T\u00e4ljedal I-B (eds) The structure and metabolism of the pancreatic islets. Pergamon Press, Oxford, pp 15\u201323"},{"key":"BF00273867_CR19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00262208","volume":"26","author":"C Hellerstr\u00f6m","year":"1984","unstructured":"Hellerstr\u00f6m C (1984) The life story of the pancreatic \u03b2 cell. Diabetologia 26: 393\u2013400","journal-title":"Diabetologia"},{"key":"BF00273867_CR20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1677\/joe.0.0880219","volume":"88","author":"JC Green","year":"1981","unstructured":"Green JC, Seifi SE, Perrin D, Howell SL (1981) Cell replication in the islets of Langerhans of adult rats: effects of pregnancy, ovariectomy and treatment with steroid hormones. J Endocrinol 88: 219\u2013224","journal-title":"J Endocrinol"},{"key":"BF00273867_CR21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1677\/joe.0.0800175","volume":"80","author":"FA Van Assche","year":"1979","unstructured":"Van Assche FA, Aerts L, Gepts W (1979) Morphological changes in the endocrine pancreas in pregnant rats with experimental diabetes. J Endocrinol 80: 175\u2013179","journal-title":"J Endocrinol"},{"key":"BF00273867_CR22","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2337\/diab.18.9.606","volume":"18","author":"G Brodsky","year":"1969","unstructured":"Brodsky G, Logothetopoulos J (1969) Streptozotocin diabetes in the mouse and guinea pig. Diabetes 18: 606\u2013611","journal-title":"Diabetes"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00273867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF00273867\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00273867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T17:07:56Z","timestamp":1644253676000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF00273867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["BF00273867"],"URL":"https:\/\/doi.org\/10.1007\/bf00273867","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]},"assertion":[{"value":"11 June 1984","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 1984","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}