{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:01:30Z","timestamp":1764784890661},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1975,3,1]],"date-time":"1975-03-01T00:00:00Z","timestamp":162864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1975,3,1]],"date-time":"1975-03-01T00:00:00Z","timestamp":162864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[1975,3]]},"DOI":"10.1007\/bf00283497","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T08:07:37Z","timestamp":1652083657000},"page":"1-8","source":"Crossref","is-referenced-by-count":36,"title":["Senescence and human chromosome changes"],"prefix":"10.1007","volume":"27","author":[{"given":"Margarete S.","family":"Mattevi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco M.","family":"Salzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF00283497_CR1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/216487a0","volume":"216","author":"A. D. Bloom","year":"1967","unstructured":"Bloom, A. D., Archer, P. G., Awa, A. A.: Variation in human chromosome number. Nature (Lond.) 216, 487\u2013489 (1967)","journal-title":"Nature (Lond.)"},{"key":"BF00283497_CR2","first-page":"93","volume":"4","author":"N. P. Bochkov","year":"1968","unstructured":"Bochkov, N. P., Kozlov, V. M., Pilosov, P. V. Sevanskaev, A. V.: The level of spontaneous chromosome aberrations in cultures of human leukocytes (Russ.). Genetika 4, 93\u201397 (1968)","journal-title":"Genetika"},{"key":"BF00283497_CR3","first-page":"2003","volume":"99","author":"M. Cadotte","year":"1970","unstructured":"Cadotte, M., Fraser, D.: \u00c9tude de l'aneuploidie observ\u00e9e dans les cultures de sang et de m\u0153lle en fonction du nombre et de longueur des chromosomes de chaque groupe et de l'\u00e2ge et du sexe des sujets. L'Union M\u00e9d Canad. 99 2003\u20132007 (1970)","journal-title":"L'Union M\u00e9d Canad."},{"key":"BF00283497_CR4","first-page":"1","volume":"42","author":"W. M. Court Brown","year":"1966","unstructured":"Court Brown, W. M., Buckton, K. C., Jacobs, P. A., Tough, I. M., Kuenssberg, E. V., Knox, J. D. E.: Chromosome studies on adults. Eugen. Lab. Mem. 42, 1\u201391 (1966)","journal-title":"Eugen. Lab. Mem."},{"key":"BF00283497_CR5","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/2111324b0","volume":"211","author":"E. K. de Gal\u00e1n","year":"1966","unstructured":"Gal\u00e1n de, E. K.: Age and chromosomes. Nature (Lond.) 211, 1324\u20131325 (1966)","journal-title":"Nature (Lond.)"},{"key":"BF00283497_CR6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00000441-196907000-00004","volume":"258","author":"R. Goodman","year":"1969","unstructured":"Goodman, R., Fechheimer, N., Miller, R., Zartman, O.: Chromosomal alterations in three age groups of human females. Amer. J. med. Sci. 258, 26\u201333 (1969)","journal-title":"Amer. J. med. Sci."},{"key":"BF00283497_CR7","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/2061232a0","volume":"206","author":"J. L. Hamerton","year":"1965","unstructured":"Hamerton, J. L., Taylor, A. I., Angell R., McGuire, V. M.: Chromosome investigations of a small isolated human population: chromosome abnormalities and distribution of chromosome counts according to age and sex among the population of Tristan da Cunha. Nature (Lond.) 206, 1232\u20131234 (1965)","journal-title":"Nature (Lond.)"},{"key":"BF00283497_CR8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000130034","volume":"8","author":"T. Honda","year":"1969","unstructured":"Honda, T., Kamada, N., Bloom, A. D.: Chromosome aberrations and culture time. Cytogenetics 8, 117\u2013124 (1969)","journal-title":"Cytogenetics"},{"key":"BF00283497_CR9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1469-1809.1963.tb01532.x","volume":"27","author":"P. A. Jacobs","year":"1964","unstructured":"Jacobs, P. A., Brunton, M., Court Brown, W. M.: Cytogenetic studies on the general population: subjects of ages 65 years and more. Ann. hum. Genet. 27, 353\u2013365 (1964)","journal-title":"Ann. hum. Genet."},{"key":"BF00283497_CR10","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/1971080a0","volume":"197","author":"P. A. Jacobs","year":"1963","unstructured":"Jacobs, P. A., Brunton, M., Court Brown, W. M., Doll, R., Goldstein, H.: Change of human chromosome count distribution with age: evidence for a sex difference. Nature (Lond.) 197, 1080\u20131081 (1963)","journal-title":"Nature (Lond.)"},{"key":"BF00283497_CR11","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/1911178a0","volume":"197","author":"P. A. Jacobs","year":"1961","unstructured":"Jacobs, P. A., Court Brown, W. M., Doll, R.: Distribution of human chromosome counts in relation to age Nature (Lond.) 197, 1178\u20131180 (1961)","journal-title":"Nature (Lond.)"},{"key":"BF00283497_CR12","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1192\/bjp.115.527.1193","volume":"115","author":"L. F. Jarvik","year":"1969","unstructured":"Jarvik, L. F., Kato, T.: Chromosome and mental changes in octogenarians\u2014preliminary findings. Brit. J. Psychol. 115, 1193\u20131194 (1969)","journal-title":"Brit. J. Psychol."},{"key":"BF00283497_CR13","first-page":"562","volume":"22","author":"L. F. Jarvik","year":"1970","unstructured":"Jarvik, L. F., Kato, T.: Chromosome examination in aged twins. Amer. J. hum. Genet. 22, 562\u2013573 (1970)","journal-title":"Amer. J. hum. Genet."},{"key":"BF00283497_CR14","unstructured":"Jarvik, L. F., Yen, F. S.: Chromosome examinations in aged singleborn women. Abst. Behav. Genet. Assoc., Third Annual Meeting, Chapel Hill, N.C., USA (1973)"},{"key":"BF00283497_CR15","doi-asserted-by":"crossref","first-page":"724","DOI":"10.2183\/pjab1945.47.724","volume":"47","author":"T. Kadotani","year":"1971","unstructured":"Kadotani, T., Ohama, K., Nakayama, T., Takahara H., Makino, S.: Chromosome aberrations in leukocytes of normal human adults from 49 couples. Proc. Jap. Acad. 47, 724\u2013728 (1971)","journal-title":"Proc. Jap. Acad."},{"key":"BF00283497_CR16","first-page":"137","volume":"4","author":"J. J. Kerkis","year":"1967","unstructured":"Kerkis, J. J., Rajabli, S. I., Pospelova, T. V., Vysotzkaya, L. M.: On the causes of progressing with age aneuploidy in human leukocytes (Russ.) Genetika 4, 137\u2013141 (1967)","journal-title":"Genetika"},{"key":"BF00283497_CR17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/225281a0","volume":"225","author":"P. Neurath","year":"1970","unstructured":"Neurath, P., DeRemer, K., Bell, B., Jarvik, L., Kato, T.: Chromosome loss compared with chromosome size, age and sex of subjects. Nature (Lond.) 225, 281\u2013282 (1970)","journal-title":"Nature (Lond.)"},{"key":"BF00283497_CR18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1192\/bjp.114.508.303","volume":"114","author":"J. Nielsen","year":"1968","unstructured":"Nielsen, J.: Chromosomes in senile dementia. Brit. J. Psychol. 114, 303\u2013309 (1968)","journal-title":"Brit. J. Psychol."},{"key":"BF00283497_CR19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/geronj\/25.4.312","volume":"25","author":"J. Nielsen","year":"1970","unstructured":"Nielsen, J.: Chromosomes in senile, presenile, and arteriosclerotic dementia. J. Geront. 25, 312\u2013315 (1970)","journal-title":"J. Geront."},{"key":"BF00283497_CR20","first-page":"633","volume":"19","author":"A. A. Sandberg","year":"1967","unstructured":"Sandberg, A. A., Cohen, W. M., Rimm, A. A., Levin, M. L.: Aneuploidy and age in a population survey. Amer. J. hum. Genet. 19, 633\u2013643 (1967)","journal-title":"Amer. J. hum. Genet."}],"container-title":["Humangenetik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00283497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/BF00283497\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00283497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T08:07:52Z","timestamp":1652083672000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/BF00283497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,3]]}},"alternative-id":["BF00283497"],"URL":"https:\/\/doi.org\/10.1007\/bf00283497","relation":{},"ISSN":["0018-7348"],"issn-type":[{"value":"0018-7348","type":"print"}],"subject":[],"published":{"date-parts":[[1975,3]]}}}