{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:07:12Z","timestamp":1771016832378,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1989,5,1]],"date-time":"1989-05-01T00:00:00Z","timestamp":609984000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[1989,5]]},"DOI":"10.1007\/bf00284054","type":"journal-article","created":{"date-parts":[[2004,10,4]],"date-time":"2004-10-04T05:31:11Z","timestamp":1096867871000},"page":"179-186","source":"Crossref","is-referenced-by-count":34,"title":["The levels of ?, ?, and ? chains in patients with Hb H disease"],"prefix":"10.1007","volume":"82","author":[{"given":"Ferdane","family":"Kutlar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Gonzalez-Redondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Kutlar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aytemiz","family":"Gurgey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\ufffdigdem","family":"Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgi D.","family":"Efremov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara","family":"Kleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titus H. J.","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1056\/NEJM198511283132207","volume":"28","author":"JG Adams III","year":"1985","unstructured":"Adams JG III, Coleman MB, Hayes J, Morrison WT, Steinberg MH (1985) Modulation of fetal hemoglobin synthesis by iron deficiency. N Engl J Med 28:1402?1405","journal-title":"N Engl J Med"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajh.2830090304","volume":"9","author":"C Altay","year":"1980","unstructured":"Altay C, Gurgey A, Tuncbilek E (1980) Hematological evaluation of patients with various combinations of ?-thalassemia. Am J Hematol 9:261?267","journal-title":"Am J Hematol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ajh.2830200313","volume":"20","author":"I Bakioglu","year":"1985","unstructured":"Bakioglu I, Hattori Y, Kutlar A, Mathew C, Huisman THJ (1985) Five adults with mild sickle cell anemia share a ?S chromosome with the same haplotype. Am J Hematol 20:297?300","journal-title":"Am J Hematol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/1841877a0","volume":"184","author":"K Betke","year":"1959","unstructured":"Betke K, Marti HR, Schlicht I (1959) Estimation of small percentages of foetal haemoglobin. Nature 184:1877?1878","journal-title":"Nature"},{"key":"CR5","volume-title":"Hemoglobin: molecular, genetic and clinical aspects","author":"HF Bunn","year":"1986","unstructured":"Bunn HF, Forget BG (1986) Hemoglobin: molecular, genetic and clinical aspects. Saunders, Philadelphia"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/science.157.3784.65","volume":"157","author":"GL Capp","year":"1967","unstructured":"Capp GL, Rigas DA, Jones RT (1967) Hemoglobin Portland 1: a new human hemoglobin unique in structure. Science 157:65?66","journal-title":"Science"},{"key":"CR7","unstructured":"Chang JC, Kan YW (1984) Deletion of the entire human ?-globin gene cluster. Clin Res 32:549A"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1182\/blood.V71.1.248.248","volume":"71","author":"JC Diaz-Chico","year":"1988","unstructured":"Diaz-Chico JC, Yang KG, Stoming TA, Efremov DG, Kutlar A, Kutlar F, Aksoy M, Altay \u00c7, Gurgey A, Kilin\u00e7 Y, Huisman THJ (1988) Mild and severe ?-thalassemia among homozygotes from Turkey; identification of the types by hybridization of amplified DNA with synthetic probes. Blood 71:248?251","journal-title":"Blood"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2141.1988.tb06197.x","volume":"68","author":"YJ Fei","year":"1988","unstructured":"Fei YJ, Fujita S, Huisman THJ (1988) Two different theta (?) globin gene deletions observed among Black newborn babies. Br J Haematol 68:249?253","journal-title":"Br J Haematol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1182\/blood.V63.5.1253.1253","volume":"63","author":"AE Felice","year":"1984","unstructured":"Felice AE, Cleek MP, McKie K, McKie V, Huisman THJ (1984) The rare ?-thalassemia-1 of Blacks is a ??-thalassemia-1 associated with a deletion of all ?- and ?-globin genes. Blood 63:1253?1257","journal-title":"Blood"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00401231","volume":"73","author":"AE Felice","year":"1986","unstructured":"Felice AE, Cleek MP, Marino EM, McKie K, McKie VC, Chang BK, Huisman THJ (1986) Different ? globin gene deletions among Black Americans. Hum Genet 73:221?224","journal-title":"Hum Genet"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood.V66.4.783.783","volume":"66","author":"JG Gilman","year":"1985","unstructured":"Gilman JG, Huisman THJ (1985) DNA sequence variation associated with elevated fetal G? globin poduction. Blood 66:783?787","journal-title":"Blood"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00561460","volume":"26","author":"JM Gonzalez-Redondo","year":"1988","unstructured":"Gonzalez-Redondo JM, Han I-S, Gu Y-C, Huisman THJ (1988a) Nucleotide sequence of the human ?1 globin gene. Biochem Genet 26:207?211","journal-title":"Biochem Genet"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1182\/blood.V72.3.1007.bloodjournal7231007","volume":"72","author":"JM Gonzalez-Redondo","year":"1988","unstructured":"Gonzalez-Redondo JM, Stoming TA, Lanclos KD, Gu YC, Kutlar A, Kutlar F, Nakatsuji T, Deng B, Han IS, McKie VC, Huisman THJ (1988b) Clinical and genetic heterogeneity in Black patients with homozygous ?-thalassemia from the Southeastern USA. Blood 72:1007?1014","journal-title":"Blood"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2141.1987.tb01306.x","volume":"66","author":"YC Gu","year":"1987","unstructured":"Gu YC, Landman H, Huisman THJ (1987) Two different quadruplicated ? globin gene arrangements. Br J Haematol 66:245?250","journal-title":"Br J Haematol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/03630268609036566","volume":"10","author":"Y Hattori","year":"1986","unstructured":"Hattori Y, Kutlar F, Kutlar A, McKie VC, Huisman THJ (1986) Haplotypes of ?S chromosomes among patients with sickle cell anemia from Georgia. Hemoglobin 10:623?642","journal-title":"Hemoglobin"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/BF00281073","volume":"75","author":"T Henni","year":"1987","unstructured":"Henni T, Morle F, Lopez B, Colonna P, Godet J (1987) ?-Thalassemia haplotypes in the Algerian population. Hum Genet 75: 272?276","journal-title":"Hum Genet"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0021-9673(00)80513-0","volume":"198","author":"JB Henson","year":"1980","unstructured":"Henson JB, Carver JR, Wilson JB, Huisman THJ (1980) Carboxymethyl-cellulose microchromatography for the quantitation of Hemoglobin Bart's (?4) and its use in the detection of the ?-thalassemia conditions. J Chromatogr 198:443?448","journal-title":"J Chromatogr"},{"key":"CR19","volume-title":"The hemoglobinopathies techniques of identification","author":"THJ Huisman","year":"1977","unstructured":"Huisman THJ, Jonxis JHP (1977) The hemoglobinopathies techniques of identification. Dekker, New York"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3109\/03630268508997037","volume":"9","author":"A Kutlar","year":"1985","unstructured":"Kutlar A, Hattori Y, Bakioglu I, Kutlar F, Kamel K, Huisman THJ (1985) Hematological observations in Arabian SS patients with a homozygosity or heterozygosity for a ?S) chromosome with haplotype no. 31. Hemoglobin 9:545?557","journal-title":"Hemoglobin"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-9673(01)95816-9","volume":"357","author":"F Kutlar","year":"1986","unstructured":"Kutlar F, Kutlar A, Huisman THJ (1986) Separation of normal and abnormal hemoglobin chains by reversed phase high performance liquid chromatography. J Chromatogr 357:147?153","journal-title":"J Chromatogr"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0021-9673(01)94185-8","volume":"394","author":"F Kutlar","year":"1987","unstructured":"Kutlar F, Fei YJ, Wilson JB, Kutlar A, Huisman THJ (1987) Detection of the embryonic ? chain in blood from newborn babies by reversed phase high performance liquid chromatography. J Chromatogr 394:333?343","journal-title":"J Chromatogr"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0378-4347(00)83036-4","volume":"487","author":"F Kutlar","year":"1989","unstructured":"Kutlar F, Hu H, Huisman THJ (1989) Quantitation of Hb Bart's, Hb H, Hb Portland-I, Hb Portland-II, and Hb Constant Spring by anion exchange high performance liquid chromatography. J Chromatogr 487:265?274","journal-title":"J Chromatogr"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1182\/blood.V65.6.1434.bloodjournal6561434","volume":"65","author":"RD Nicholls","year":"1985","unstructured":"Nicholls RD, Higgs DR, Clegg JB, Weatherall DJ (1985) 186-6 due to recombination between the ?1-globin gene and an AluI repeat. Blood 65:1434?1438","journal-title":"Blood"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0092-8674(87)90289-3","volume":"49","author":"RD Nicholls","year":"1987","unstructured":"Nicholls RD, Fischel-Ghodsian N, Higgs DR (1987) Recombination at the human ?-globin gene cluster: sequence features and topological constraints. Cell 49:369?378","journal-title":"Cell"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/286538a0","volume":"286","author":"SH Orkin","year":"1980","unstructured":"Orkin SH, Michelson A (1980) Partial deletion of the ?-globin structural gene in human ?-thalassaemia. Nature 286:538?540","journal-title":"Nature"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0092-8674(79)90292-7","volume":"17","author":"SH Orkin","year":"1979","unstructured":"Orkin SH, Old J, Lazarus H, Altay C, Gurgey A, Weatherall DJ, Nathan DG (1979) The molecular basis of ?-thalassemias: frequent occurrence of dysfunctional ? loci among non-Asians with Hb H disease. Cell 17:33?42","journal-title":"Cell"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1073\/pnas.78.8.5041","volume":"78","author":"SH Orkin","year":"1981","unstructured":"Orkin SH, Goff SC, Hechtman RL (1981) Mutation in an intervening sequence splice junction in man. Proc Natl Acad Sci USA 78: 5041?5045","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2141.1986.tb07525.x","volume":"63","author":"E Paglietti","year":"1986","unstructured":"Paglietti E, Galanello R, Moi P, Pirastu M, Cao A (1986) Molecular pathology of haemoglobin H disease in Sardinians. Br J Haematol 63:485?496","journal-title":"Br J Haematol"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/03630268208996930","volume":"6","author":"M Poncz","year":"1982","unstructured":"Poncz M, Solowiejczyk D, Harpel B, Mory Y, Schwartz E, Surrey S (1982) Construction of human gene libraries from small amounts of peripheral blood: analysis of ?-like globin genes. Hemoglobin 6:27?36","journal-title":"Hemoglobin"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1073\/pnas.77.6.3586","volume":"77","author":"L Pressley","year":"1980","unstructured":"Pressley L, Higgs DR, Clegg JB, Weatherall DJ (1980) Gene deletions in ?-thalassemia prove than the 5? ? locus is functional. Proc Natl Acad Sci USA 77:3586?3589","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/ajh.2830290116","volume":"29","author":"CC Qiu","year":"1988","unstructured":"Qiu CC, Abraham EC (1988) Evidence for posttranslational control of fetal hemoglobin synthesis. Am J Hematol 29:58?59","journal-title":"Am J Hematol"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1016\/S0021-9258(17)39875-7","volume":"259","author":"ZI Randhawa","year":"1984","unstructured":"Randhawa ZI, Jones RT, Lie-Injo LE (1984) Human Hemoglobin Portland II (?2?2) ? isolation and characterization of Portland hemoglobin components and their constituent globin chains. J Biol Chem 259:7325?7330","journal-title":"J Biol Chem"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3109\/03630267709027867","volume":"1","author":"CTH Schleider","year":"1977","unstructured":"Schleider CTH, Mayson SM, Huisman THJ (1977) Further modification of the microchromatographic determination of Hemoglobin A2. Hemoglobin 1:503?504","journal-title":"Hemoglobin"},{"key":"CR35","volume-title":"The chromatography of hemoglobin","author":"WA Schroeder","year":"1980","unstructured":"Schroeder WA, Huisman THJ (1980) The chromatography of hemoglobin. Dekker, New York"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1080\/01483918408068849","volume":"7","author":"JB Shelton","year":"1984","unstructured":"Shelton JB, Shelton JR, Schroeder WA (1984) High performance liquid chromatographic separation of globin chains on a large-pore C4 column. J Liquid Chromatogr 7:1969?1977","journal-title":"J Liquid Chromatogr"},{"key":"CR37","volume-title":"The thalassaemia syndromes","author":"DJ Weatherall","year":"1981","unstructured":"Weatherall DJ, Clegg JB (1981) The thalassaemia syndromes, 3rd edn. Blackwell, Oxford","edition":"3rd edn."},{"key":"CR38","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/j.1460-2075.1984.tb02051.x","volume":"3","author":"P Winichagoon","year":"1984","unstructured":"Winichagoon P, Higgs DR, Goodbourn SEY, Clegg JB, Weatherall DJ, Wasi P (1984) The molecular basis of ?-thalassaemia in Thailand. EMBO J 3:1813?1818","journal-title":"EMBO J"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00284054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00284054\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00284054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T03:58:42Z","timestamp":1624679922000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00284054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,5]]}},"alternative-id":["BF00284054"],"URL":"https:\/\/doi.org\/10.1007\/bf00284054","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,5]]}}}