{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:10:09Z","timestamp":1791130209899,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[1985,3]]},"DOI":"10.1007\/bf00293026","type":"journal-article","created":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T16:39:18Z","timestamp":1100018358000},"page":"209-211","source":"Crossref","is-referenced-by-count":49,"title":["Analysis of the fragile-X chromosome: localization and detection of the fragile site in high resolution preparations"],"prefix":"10.1007","volume":"69","author":[{"given":"M. S.","family":"Krawczun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. C.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. T.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF00291345","volume":"61","author":"G Barbi","year":"1982","unstructured":"Barbi G, Steinbach P (1982) Increase in the incidence of the fragile site Xq27 in prometaphases. Hum Genet 61:82","journal-title":"Hum Genet"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/BF00285034","volume":"65","author":"G Barbi","year":"1983","unstructured":"Barbi G, Steinbach P, Wiedenmann A, Vogel W (1983) Manifestation of the fragile site Xq27 in fibroblasts. Hum Genet 65:76?78","journal-title":"Hum Genet"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00285404","volume":"63","author":"R Brookwell","year":"1983","unstructured":"Brookwell R, Turner G (1983) High resolution banding and the locus of the Xq fragile site. Hum Genet 63:77","journal-title":"Hum Genet"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ajmg.1320130206","volume":"13","author":"R Brookwell","year":"1982","unstructured":"Brookwell R, Daniel A, Turner G, Fishburn J (1982) The fragile X(q27) form of X-linked mental retardation: FUdR as an inducing agent for fra(X)(q27) expression in lymphocytes, fibroblasts, and amniocytes. Am J Med Genet 13:139?148","journal-title":"Am J Med Genet"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1399-0004.1984.tb00475.x","volume":"25","author":"GB Gardiner","year":"1984","unstructured":"Gardiner GB, Wenger SL, Steele MW (1984) In vitro reversal of fragile-X expression by exogenous thymidine. Clin Genet 25:135?139","journal-title":"Clin Genet"},{"key":"CR6","first-page":"234","volume":"33","author":"TW Glover","year":"1981","unstructured":"Glover TW (1981) FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition. Am J Hum Genet 33:234?242","journal-title":"Am J Hum Genet"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/jmg.20.4.280","volume":"20","author":"CJ Harrison","year":"1983","unstructured":"Harrison CJ, Jack EM, Allen TD, Harris R (1983) The fragile X: a scanning electron microscope study. J Med Genet 20:280?285","journal-title":"J Med Genet"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000131620","volume":"31","author":"ISCN","year":"1981","unstructured":"ISCN (1981) An international system for human cytogenetic nomenclature ? high resolution banding (1981). Cytogenet Cell Genet 31:1?23","journal-title":"Cytogenet Cell Genet"},{"key":"CR9","first-page":"171","volume":"26","author":"PB Jacky","year":"1983","unstructured":"Jacky PB, Dill FJ (1983) Fragile X chromosome and chromosome condensation. Ann Genet (Paris) 26:171?173","journal-title":"Ann Genet (Paris)"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1159\/000130208","volume":"11","author":"HP Klinger","year":"1972","unstructured":"Klinger HP (1972) Rapid processing of primary embryonic tissue for chromosome banding analysis. Cytogenetics 11:424?435","journal-title":"Cytogenetics"},{"key":"CR11","first-page":"231","volume":"21","author":"HA Lubs","year":"1968","unstructured":"Lubs HA (1968) A marker X chromosome. Am J Hum Genet 21: 231?244","journal-title":"Am J Hum Genet"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00278298","volume":"51","author":"M Marcus","year":"1979","unstructured":"Marcus M, Goiten R, Gropp A (1979) Condensation of all human chromosomes in phase G2 and early mitosis can be dratically inhibited by 33258 Hoechst treatment. Hum Genet 51:99?105","journal-title":"Hum Genet"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000131858","volume":"35","author":"T Matsubara","year":"1983","unstructured":"Matsubara T, Nakagame Y (1983) High-resolution banding by treating cells with acridine organe before fixation. Cytogenet Cell Genet 35:148?151","journal-title":"Cytogenet Cell Genet"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1399-0004.1983.tb01978.x","volume":"23","author":"W Silverman","year":"1983","unstructured":"Silverman W, Lubin R, Jenkins EC, Brown WT (1983) The strength of association between fragile (X) chromosome presence and mental retardation. Clin Genet 23:436?440","journal-title":"Clin Genet"},{"key":"CR15","unstructured":"Simola KOJ (1984) X-linked mental retardation with the marker X chromosome?A clinical and cytogenetic study. Ph.D. Dissertation, University of Helsinki"},{"key":"CR16","first-page":"125","volume":"31","author":"GR Sutherland","year":"1979","unstructured":"Sutherland GR (1979) Heritable fragile sites on human chromosomes. I. Factors affecting expression in lymphocyte culture. Am J Hum Genet 31:125?135","journal-title":"Am J Hum Genet"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0014-4827(76)90445-6","volume":"98","author":"E Viegas-Pequignot","year":"1976","unstructured":"Viegas-Pequignot E, Dutrillaux B (1976) Modification specifique des bandes Q et R par le 5-bromodeoxyuridine et l'actinomycin D. Exp Cell Res 98:338?348","journal-title":"Exp Cell Res"},{"key":"CR18","volume-title":"Statistical principles in experimental design","author":"BJ Winer","year":"1971","unstructured":"Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill Co, New York"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00274682","volume":"56","author":"JJ Yunis","year":"1981","unstructured":"Yunis JJ (1981) Mid-prophase human chromosomes. The attainment of 2000 bands. Hum Genet 56:293?298","journal-title":"Hum Genet"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00293026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00293026\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00293026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T20:11:34Z","timestamp":1554754294000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00293026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["BF00293026"],"URL":"https:\/\/doi.org\/10.1007\/bf00293026","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}