{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:15:13Z","timestamp":1775985313725,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[1990,9]]},"DOI":"10.1007\/bf00294616","type":"journal-article","created":{"date-parts":[[2004,10,6]],"date-time":"2004-10-06T04:33:43Z","timestamp":1097037223000},"page":"541-546","source":"Crossref","is-referenced-by-count":69,"title":["Neuropathology in Kearns-Sayre syndrome"],"prefix":"10.1007","volume":"80","author":[{"given":"A.","family":"Oldfors","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. -M.","family":"Fyhr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Holme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. -G.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tulinius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF00687459","volume":"23","author":"M Adachi","year":"1973","unstructured":"Adachi M, Torii J, Volk BW, Briet P, Wolintz A, Schneck L (1973) Electron microscopic and enzyme histochemical studies of cerebellum, ocular and skeletal muscles in chronic progressive ophthalmoplegia with cerebellar ataxia. Acta Neuropathol (Berl) 23:300?312","journal-title":"Acta Neuropathol (Berl)"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ana.410010104","volume":"1","author":"RA Berenberg","year":"1977","unstructured":"Berenberg RA, Pellock JM, DiMauro S, Schotland DL, Bonilla E, Eastwood A, Hays A, Vicale CT, Behrens M, Chutorian A, Rowland LP (1977) Lumping or splitting? ?Ophthalmoplegia plus? or Kearns-Sayre syndrome? Ann Neurol 1:37?54","journal-title":"Ann Neurol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ana.410210607","volume":"21","author":"N Bresolin","year":"1987","unstructured":"Bresolin N, Moggio M, Bet L, Gallanti A, Prelle A, Nobile-Orazio E, Adobbati L, Ferrante C, Pellegrini G, Scarlato G (1987) Progressive cytochrome c oxidase deficiency in a case of Kearns-Sayre syndrome: morphological, immunological and biochemical studies in muscle biopsies and autopsy tissue. Ann Neurol 21:564?572","journal-title":"Ann Neurol"},{"key":"CR4","first-page":"125","volume-title":"Greenfield's neuropathology","author":"JB Brierley","year":"1984","unstructured":"Brierley JB, Graham DI (1984) Hypoxia and vascular disorders of the central nervous system. In: Adams JH, Corsellis JAN, Duchan LW (eds) Greenfield's neuropathology, 4th edn. Edward Arnold, London, pp 125?207","edition":"4th edn."},{"key":"CR5","first-page":"454","volume":"124","author":"P Castaigne","year":"1971","unstructured":"Castaigne P, Laplane D, Escourolle R, Augustin P, de Recondo J, Martinez GJ, Villanueva Eusa JA (1971) Ophtalmopl\u00e9gie externe progressive avec spongiose des noyaux du tronc c\u00e9r\u00e9bral. Rev Neurol (Paris) 124:454?466","journal-title":"Rev Neurol (Paris)"},{"key":"CR6","first-page":"369","volume":"133","author":"P Castaigne","year":"1977","unstructured":"Castaigne P, Lhermitte F, Escourolle R, Chain F, Fardeau F, Hauw J, Curet J, Flavigny C (1977) Etude anatomo-clinique d'une observation d'?Ophtalmoplegia plus? avec analyse des l\u00e9sions musculaires, nerveuses centrales, oculaires, myocardiques et thyroidiennes. Rev Neurol (Paris) 133:369?386","journal-title":"Rev Neurol (Paris)"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1378\/chest.68.5.727","volume":"68","author":"DS Clare","year":"1975","unstructured":"Clare DS, Myrburg RJ, Morales AR, Befeler B, Hernandez FA, Gelband H (1975) Heart block in Kearns-Sayre syndrome. Electrophysiologic-pathologic correlation. Chest 68:727?730","journal-title":"Chest"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1212\/WNL.16.2_Part_1.161","volume":"16","author":"RB Daroff","year":"1966","unstructured":"Daroff RB, Solitare GB, Pincus JH, Glaser GH (1966) Spongiform encephalopathy with chronic progressive external ophthalmoplegia. Central ophthalmoplegia mimicking ocular myopathy. Neurology 16:161?169","journal-title":"Neurology"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ana.410170602","volume":"17","author":"S DiMauro","year":"1985","unstructured":"DiMauro S, Bonilla E, Zeviani M, Nakagawa M, DeVivo DC (1985) Mitochondrial myopathies. Ann Neurol 17:521?538","journal-title":"Ann Neurol"},{"key":"CR10","first-page":"466","volume-title":"Topographic brain chemistry","author":"RL Friede","year":"1966","unstructured":"Friede RL (1966) Topographic brain chemistry. Academic Press, New York, pp 466?468 and pp 105?106"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/978-3-642-73697-1_40","volume-title":"Developmental neuropathology","author":"RL Friede","year":"1989","unstructured":"Friede RL (1989) Developmental neuropathology, 2nd edn. Springer, Berlin Heidelberg, pp 510?533","edition":"2nd edn."},{"key":"CR12","first-page":"374","volume-title":"Experimental and clinical neurotoxicology","author":"MD Ginsburg","year":"1980","unstructured":"Ginsburg MD (1980) Carbon monoxide. In: Spencer PS, Schaumburg HH (eds) Experimental and clinical neurotoxicology. Williams & Wilkins, Baltimore, pp 374?394"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ana.410080406","volume":"8","author":"DR Groothuis","year":"1980","unstructured":"Groothuis DR, Schulman S, Wollman R, Frey J, Vick NA (1980) Demyelinating radiculopathy in the Kearns-Sayre syndrome: a clinicopathological study. Ann Neurol 8:373?380","journal-title":"Ann Neurol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF02878455","volume":"79","author":"J Hallervorden","year":"1922","unstructured":"Hallervorden J, Spatz H (1922) Eigenartige Erkrankung im extrapyramidalen System mit besonderer Beteiligung des Globus pallidus und der Substantia nigra. Z Neurol Psychiatr 79:254?302","journal-title":"Z Neurol Psychiatr"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ana.410030611","volume":"3","author":"S Horwitz","year":"1978","unstructured":"Horwitz S, Roessmann U (1978) Kearns-Sayre syndrome with hypoparathyroidism. Ann Neurol 3:513?518","journal-title":"Ann Neurol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/0002-9343(60)90122-4","volume":"7","author":"BV Jager","year":"1960","unstructured":"Jager BV, Fred HL, Butler RB, Carnes WH (1960) Occurrence of retinal pigmentation, ophthalmoplegia, ataxia, deafness, and heart block. Am J Med 7:888?893","journal-title":"Am J Med"},{"key":"CR17","first-page":"133","volume":"64","author":"H Kalimo","year":"1986","unstructured":"Kalimo H, Fredriksson K, Nordborg C, Auer RN, Olsson Y, Johansson B (1986) The spread of brain oedema in hypertensive brain injury. Med Biol 64:133?137","journal-title":"Med Biol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/archopht.1958.00940080296016","volume":"60","author":"TP Kearns","year":"1958","unstructured":"Kearns TP, Sayre GP (1958) Retinitis pigmentosa, external ophthalmoplegia, and complete heart block. Arch Ophthalmol 60:280?289","journal-title":"Arch Ophthalmol"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1203\/00006450-199008000-00011","volume":"28","author":"N-G Larsson","year":"1990","unstructured":"Larsson N-G, Holme E, Kristiansson B, Oldfors A, Tulinius M (1990) Progressive increase of the mutated mitochondrial DNA fraction in Kearns-Sayre syndrome. Pediatr Res 28:131?136","journal-title":"Pediatr Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0140-6736(88)91632-7","volume":"I","author":"P Lestienne","year":"1988","unstructured":"Lestienne P, Ponsot G (1988) Kearns-Sayre syndrome with muscle DNA deletion. Lancet I:885","journal-title":"Lancet"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJM198905183202001","volume":"320","author":"CR Moraes","year":"1989","unstructured":"Moraes CR, DiMauro S, Zeviani M, Lombes A, Shanske S, Miranda AF, Nakase H, Bonilla E, Werneck LC, Servidei S, Nonaka I, Koga Y, Spiro AJ, Brownell KW, Schmidt B, Schotland DL, Zupanc M, De Vivo DC, Schon EA, Rowland LP (1989) Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome. N Engl J Med 320:1293?1299","journal-title":"N Engl J Med"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF00687578","volume":"77","author":"A Oldfors","year":"1989","unstructured":"Oldfors A, Sommerland H, Holme E, Tulinius M, Kristiansson B (1989) Cytochrome c oxidase deficiency in infancy. Acta Neuropathol 77:267?275","journal-title":"Acta Neuropathol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0022-510X(90)90116-5","volume":"95","author":"W Paulus","year":"1990","unstructured":"Paulus W, Pfeiffer J (1990) Intracerebral distribution of mitochondrial abnormalities in 21 cases of infantile spongy dystrophy. J Neurol Sci 95:49?62","journal-title":"J Neurol Sci"},{"key":"CR24","first-page":"118","volume-title":"Experimental and clinical neurotoxicology","author":"HC Powell","year":"1980","unstructured":"Powell HC, Myers RR, Lamperts PW (1980) Edema in neurotoxic injury. In: Spencer PS, Schaumburg HH (eds) Experimental and clinical neurotoxicology. Williams & Wilkins, Baltimore, pp 118?138"},{"key":"CR25","first-page":"141","volume-title":"Mitochondrial pathology in muscle diseases","author":"LP Rowland","year":"1983","unstructured":"Rowland LP, Hays AP, DiMauro S, DeVivo DC, Behrens M (1983) Diverse clinical disorders associated with morphological abnormalities of mitochondria. In: Scarlato G, Cerri C (eds) Mitochondrial pathology in muscle diseases. Piccin Medical Books, Padua, pp 141?158"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-510X(73)90054-3","volume":"19","author":"L Schneck","year":"1973","unstructured":"Schneck L, Adachi M, Briet P, Wolintz A, Volk BW (1973) Ophthalmoplegia plus with morphological and chemical studies of cerebellar and muscle tissue. J Neurol Sci 19:37?44","journal-title":"J Neurol Sci"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1212\/WNL.38.9.1339","volume":"38","author":"M Zeviani","year":"1988","unstructured":"Zeviani M, Moraes CT, DiMauro S, Nakase H, Bonilla E, Schon EA, Rowland LP (1988) Deletions of mitochondrial DNA in Kearns-Sayre syndrome. Neurology 38:1339?1346","journal-title":"Neurology"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00294616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00294616\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00294616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T16:12:05Z","timestamp":1554739925000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00294616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["BF00294616"],"URL":"https:\/\/doi.org\/10.1007\/bf00294616","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}