{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:07:29Z","timestamp":1765267649345},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Surgery for gastric cancer in Japan has frequently been combined with resection of the spleen (splenectomy) or of the pancreatic body and tail and spleen (pancreatosplenectomy, PS). Splenectomy in patients with gastric cancer has been performed with two major purposes in mind: (1) curability of the cancer and (2) immunologic reasons. Direct cancerous invasion to the pancreas requires PS, although examination of these cases revealed that in 34.3% of such macroscopic invasions only fibrous adhesion to pancreas existed. Metastases to lymph nodes at the splenic hilus (no. 10) or along the splenic artery (no. 11) also required splenectomy. The incidences of no. 10 or no. 11 lymph node metastasis were as high as 26.7% and 22.2% respectively, for cancers of whole stomach, and 15.5% and 12.1% for cancers of the upper portion of stomach. Concerning the immunologic aspect of splenectomy for gastric cancer, the reports of fundamental research and clinical studies suggest that the spleen plays sometimes acts as a suppressor and at other times as a helper to the tumor activity, according to the number of tumor cells. From these data, we concluded that the spleen should be preserved in stage I, II, and III patients with curative operation; for stage IV patients the spleen should be resected. The immunologic significance of splenectomy should be clarified precisely in the near future.<\/jats:p>","DOI":"10.1007\/bf00294715","type":"journal-article","created":{"date-parts":[[2004,10,6]],"date-time":"2004-10-06T08:54:55Z","timestamp":1097052895000},"page":"537-540","source":"Crossref","is-referenced-by-count":63,"title":["Splenectomy for treatment of gastric cancer: Japanese experience"],"prefix":"10.1002","volume":"19","author":[{"given":"Kunio","family":"Okajima","sequence":"first","affiliation":[{"name":"Department of Surgery Osaka Medical College 2\u20107 Daigaku\u2010machi 569 Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Isozaki","sequence":"additional","affiliation":[{"name":"Department of Surgery Osaka Medical College 2\u20107 Daigaku\u2010machi 569 Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,7]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"TNM Classification of Malignant Tumours","author":"UICC","year":"1987"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02468883"},{"key":"e_1_2_1_4_1","first-page":"328","article-title":"Significance of combined pancreatosplenectomy in gastric resection for gastric carcinoma","volume":"2","author":"Kanai H.","year":"1967","journal-title":"J. Jpn. Soc. Cancer Ther."},{"key":"e_1_2_1_5_1","first-page":"80","article-title":"Combined resection of pancreas in gastric cancer","volume":"10","author":"Kajitani T.","year":"1964","journal-title":"Gekachiryo"},{"key":"e_1_2_1_6_1","first-page":"533","article-title":"Clinicopathological study on the significance of combined pancreatosplenectomy, especially, gross indication of the basis on the base of oncological features","volume":"50","author":"Aikou T.","year":"1980","journal-title":"Igakukenkyu"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655804"},{"key":"e_1_2_1_8_1","first-page":"11","article-title":"Extended radical surgery for gastric cancer","volume":"15","author":"Jinnai D.","year":"1961","journal-title":"Syujutu"},{"key":"e_1_2_1_9_1","first-page":"337","article-title":"Splenectomy in total gastrectomy","volume":"36","author":"Sugimachi K.","year":"1982","journal-title":"Syujutu"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831101)52:9<1624::AID-CNCR2820520914>3.0.CO;2-O"},{"key":"e_1_2_1_11_1","first-page":"1539","article-title":"Is a splenectomy in the operation for gastric carcinoma useful or harmful to survival?","volume":"39","author":"Yoshino K.","year":"1984","journal-title":"Rinsyogeka"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.5833\/jjgs.12.955"},{"key":"e_1_2_1_13_1","first-page":"1059","article-title":"Effect of splenectomy in the operation for gastric cancer on the immunological status","volume":"25","author":"Takahashi M.","year":"1979","journal-title":"Gan No Rinsyo"},{"key":"e_1_2_1_14_1","first-page":"1887","article-title":"Effect of splenectomy on the prognosis in gastric cancer patients","volume":"9","author":"Toge T.","year":"1989","journal-title":"Syokakigeka"},{"key":"e_1_2_1_15_1","first-page":"2913","article-title":"Splenectomy for cancer therapy","volume":"60","author":"Miwa H.","year":"1983","journal-title":"Rinsyo To Kenkyu"},{"key":"e_1_2_1_16_1","first-page":"1535","article-title":"Significance of lymph node dissection at the splenic hilus along the splenic artery","volume":"39","author":"Miyashita K.","year":"1984","journal-title":"Rinsyo Geka"},{"key":"e_1_2_1_17_1","first-page":"1509","article-title":"Is combined resection necessary for no. 10 and no. 11 lymph node dissection in radical gastrectomy?","volume":"7","author":"Maruyama K.","year":"1984","journal-title":"Syokakigeka"},{"key":"e_1_2_1_18_1","article-title":"Evaluation of splenectomy on the prognosis of gastric cancer patients, with special reference to effects of post\u2010operative immunochemotherapy","volume":"165","author":"Saji S.","year":"1991","journal-title":"Syokakigan"},{"key":"e_1_2_1_19_1","first-page":"721","article-title":"Induction of tumoricidal effectors from the tumor\u2010bearer's splenocytes and the prospects of their utilization for the adoptive immunotherapy","volume":"21","author":"Takagi H.","year":"1986","journal-title":"J. Jpn. Soc. Cancer Ther."}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00294715.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00294715\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF00294715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T19:44:08Z","timestamp":1703706248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF00294715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1007\/BF00294715"],"URL":"https:\/\/doi.org\/10.1007\/bf00294715","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}