{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:30:42Z","timestamp":1770478242726,"version":"3.49.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1976,1,1]],"date-time":"1976-01-01T00:00:00Z","timestamp":189302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[1976]]},"DOI":"10.1007\/bf00295619","type":"journal-article","created":{"date-parts":[[2004,11,7]],"date-time":"2004-11-07T22:29:48Z","timestamp":1099866588000},"page":"57-70","source":"Crossref","is-referenced-by-count":26,"title":["The human leukocyte test system"],"prefix":"10.1007","volume":"35","author":[{"given":"Bernd","family":"Beek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\ufffdnter","family":"Obe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0027-5107(74)90185-7","volume":"24","author":"B. Beek","year":"1974","unstructured":"Beek, B., Obe, G.: The human leukocyte test system II. Different sensitivities of sub-populations to a chemical mutagen. Mutat. Res. 24, 395?398 (1974)","journal-title":"Mutat. Res."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0027-5107(75)90032-9","volume":"29","author":"B. Beek","year":"1975","unstructured":"Beek, B., Obe, G.: The human leukocyte test system IV. The RNA-synthesis pattern in the first G1-phase of the cell cycle after stimulation with PHA. Mutat. Res. 29, 165?168 (1975)","journal-title":"Mutat. Res."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000129716","volume":"1","author":"M. A. Bender","year":"1962","unstructured":"Bender, M. A., Gooch, P. C., Prescott, D. M.: Aberrations induced in human leukocyte chromosomes by (3H)labeled nucleosides. Cytogenetics 1, 65?74 (1962)","journal-title":"Cytogenetics"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0027-5107(69)90016-5","volume":"8","author":"M. A. Bender","year":"1969","unstructured":"Bender, M. A., Brewen, J. G.: Factors influencing chromosome aberration yields in the human peripheral leukocyte system. Mutat. Res. 8, 383?399 (1969)","journal-title":"Mutat. Res."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2307\/3572182","volume":"28","author":"J. G. Brewen","year":"1966","unstructured":"Brewen, J. G., Olivieri, G.: The kinetics of chromatid aberrations induced in Chinese hamster cells by tritium-labeled thymidine. Radiat. Res. 28, 779?792 (1966)","journal-title":"Radiat. Res."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/202714a0","volume":"202","author":"K. E. Buckton","year":"1964","unstructured":"Buckton, K. E., Pike, M. C.: Chromosome investigations on lymphocytes from irradiated patients. Effect of time in culture. Nature (Lond.) 202, 714?715 (1964)","journal-title":"Nature (Lond.)"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.177.4053.996","volume":"177","author":"J. E. Cleaver","year":"1972","unstructured":"Cleaver, J. E., Thomas, G. H.: Biological damage from intranuclear tritium: DNA strand breaks and their repair. Science 177, 996?998 (1972)","journal-title":"Science"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2307\/3571572","volume":"24","author":"W. C. Dewey","year":"1965","unstructured":"Dewey, W. C., Humphrey, R. M., Jones, B. A.: Comparisons of tritiated thymidine, tritiated water, and cobalt-60 gamma rays in inducing chromosomal aberrations. Radiat. Res. 24, 214?238 (1965)","journal-title":"Radiat. Res."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0027-5107(74)90149-3","volume":"23","author":"G. Dudin","year":"1974","unstructured":"Dudin, G., Beek, B., Obe, G.: The human leukocyte test system I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures. Mutat. Res. 23, 279?281 (1974)","journal-title":"Mutat. Res."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00295823","volume":"32","author":"G. Dudin","year":"1976","unstructured":"Dudin, G., Beek, B., Obe, G.: The human leukocyte test system VIII. DNA synthesis and mitoses in 3-day cultures stimulated with pokeweed mitogen. Human Genet. 32, 323?327 (1976)","journal-title":"Human Genet."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0014-4827(63)80014-2","volume":"29","author":"R. G. Ham","year":"1963","unstructured":"Ham, R. G.: An improved nutrient solution for diploid Chinese hamster and human cell lines. Exp. Cell Res. 29, 515?526 (1963)","journal-title":"Exp. Cell Res."},{"key":"CR12","first-page":"6","volume-title":"Human Radiation Cytogenetics","author":"J. A. Heddle","year":"1967","unstructured":"Heddle, J. A., Evans, H. J., Scott, D.: Sampling time and the complexity of the human leukocyte culture system: In: Human Radiation Cytogenetics (eds. H. J. Evans, W. M. Court Brown, A. S. McLean), pp. 6?19. Amsterdam: North Holland 1967"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0014-4827(70)90455-6","volume":"61","author":"J. Jasi?ska","year":"1970","unstructured":"Jasi?ska, J., Steffen, J. A., Michalowski, A.: Studies on in vitro lymphocyte proliferation in cultures synchronized by the inhibition of DNA synthesis II. Kinetics of the initiation of the proliferative response. Exp. Cell Res. 61, 333?341 (1970)","journal-title":"Exp. Cell Res."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/BF02008311","volume":"28","author":"J. Johansen","year":"1972","unstructured":"Johansen, J.: DNA synthesis and distribution of first and second division in 72-h-cultures of human leukocytes. Experientia (Basel) 28, 416?417 (1972)","journal-title":"Experientia (Basel)"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0014-4827(63)90202-7","volume":"32","author":"A. Michalowski","year":"1963","unstructured":"Michalowski, A.: Time-course of DNA synthesis in human leukocyte cultures. Exp. Cell Res. 32, 609?612 (1963)","journal-title":"Exp. Cell Res."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3181\/00379727-73-17557","volume":"73","author":"J. F. Morgan","year":"1950","unstructured":"Morgan, J. F., Morton, M. J., Parker, R. C.: Nutrition of animal cells in tissue culture. Initial studies on a synthetic medium. Proc. Soc. exp. Biol. (N.Y.) 73, 1?8 (1950)","journal-title":"Proc. Soc. exp. Biol. (N.Y.)"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0027-5107(75)90276-6","volume":"27","author":"G. Obe","year":"1975","unstructured":"Obe, G., Beek, B., Vaidya, V. G.: The human leukocyte test system III. Premature chromosome condensation from chemically and X-ray induced micronuclei. Mutat. Res. 27, 89?101 (1975a)","journal-title":"Mutat. Res."},{"key":"CR18","first-page":"295","volume":"28","author":"G. Obe","year":"1975","unstructured":"Obe, G., Beek, B., Dudin, G.: The human leukocyte test system V. DNA synthesis and mitoses in PHA-stimulated 3-day cultures. Humangenetik 28, 295?302 (1975b)","journal-title":"Humangenetik"},{"key":"CR19","first-page":"143","volume":"30","author":"G. Obe","year":"1975","unstructured":"Obe, G., Beek, B.: The human leukocyte test system VII. Further investigations concerning micronucleus-derived premature chromosome condensation. Humangenetik 30, 143?154 (1975)","journal-title":"Humangenetik"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00286850","volume":"33","author":"G. Obe","year":"1976","unstructured":"Obe, G., Brandt, K., Beek, B.: The human leukocyte test system IX. DNA synthesis and mitoses in PHA-stimulated 2-day cultures set up with Eagle's minimal essential medium (MEM). Human Genet. 33, 263?268 (1976)","journal-title":"Human Genet."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0014-4827(69)90039-1","volume":"56","author":"J. A. Steffen","year":"1969","unstructured":"Steffen, J. A., Stolzmann, W. M.: Studies on in vitro lymphocyte proliferation in cultures synchronized by the inhibition of DNA synthesis I. Variability of S plus G2 periods of first generation cells. Exp. Cell Res. 56, 453?460 (1969)","journal-title":"Exp. Cell Res."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0027-5107(73)90008-0","volume":"17","author":"J. A. Steffen","year":"1973","unstructured":"Steffen, J. A., Michalowski, A.: Heterogeneous chromosomal radiosensitivity of phytohaemagglutinin-stimulated human blood lymphocytes in culture. Mutat. Res. 17, 367?376 (1973)","journal-title":"Mutat. Res."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1073\/pnas.43.1.122","volume":"43","author":"J. H. Taylor","year":"1957","unstructured":"Taylor, J. H., Woods, P. S., Hughes, W. L.: The organization and duplication of chromosomes as revealed by autoradiographic studies using tritium-labelled thymidine. Proc. nat. Acad. Sci. (Wash.) 43, 122?128 (1957)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00295619.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00295619\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00295619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T16:12:22Z","timestamp":1554739942000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00295619"}},"subtitle":["X. Higher sensitivity to X-irradiation in the G0 stage of the cell cycle of early as compared to late replicating cells"],"short-title":[],"issued":{"date-parts":[[1976]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976]]}},"alternative-id":["BF00295619"],"URL":"https:\/\/doi.org\/10.1007\/bf00295619","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976]]}}}