{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:27:18Z","timestamp":1792168038477,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1987,12,1]],"date-time":"1987-12-01T00:00:00Z","timestamp":565315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[1987,12]]},"DOI":"10.1007\/bf00295875","type":"journal-article","created":{"date-parts":[[2004,10,6]],"date-time":"2004-10-06T09:38:54Z","timestamp":1097055534000},"page":"924-929","source":"Crossref","is-referenced-by-count":35,"title":["Counterregulation in Type 2 (non-insulin-dependent) diabetes mellitus. Normal endocrine and glycaemic responses, up to ten years after diagnosis"],"prefix":"10.1007","volume":"30","author":[{"given":"S. R.","family":"Heller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. A.","family":"Macdonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. B.","family":"Tattersall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1126\/science.182.4108.171","volume":"182","author":"JE Gerich","year":"1973","unstructured":"Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH (1973) Lack of glucagon response to hypoglycaemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 182: 171?173","journal-title":"Science"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2337\/diab.32.2.134","volume":"32","author":"G Bolli","year":"1983","unstructured":"Bolli G, De Feo P, Compagnucci P, Cartechini MG, Angeletti G, Santeusanio F, Brunetti P, Gerich JE (1983) Abnormal glucose counterregulation in insulin-dependent diabetes mellitus: interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 32: 134?141","journal-title":"Diabetes"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1172\/JCI110455","volume":"69","author":"DA Popp","year":"1982","unstructured":"Popp DA, Shah SD, Cryer PE (1982) Role of epinephrine mediated beta adrenergic mechanisms in hypoglycemic glucose counterregulation and posthypoglycemic hyperglycemia in IDDM. J Clin Invest 69: 315?326","journal-title":"J Clin Invest"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1056\/NEJM198111123052007","volume":"305","author":"G Boden","year":"1981","unstructured":"Boden G, Reichard GA, Hoeldtke RD, Rezvani I, Owen OE (1981) Severe insulin-induced hypoglycemia associated with deficiencies in the release of counterregulatory hormones. N Engl J Med 305: 1200?1205","journal-title":"N Engl J Med"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM198303033080903","volume":"308","author":"NH White","year":"1983","unstructured":"White NH, Skor DA, Cryer PE, Levandoski LA, Bier DM, Santiago JV (1983) Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 308: 485?491","journal-title":"N Engl J Med"},{"key":"CR6","first-page":"404","volume":"24","author":"Multicentre Study","year":"1983","unstructured":"Multicentre Study (1983) UK prospective study of therapies of maturity onset diabetes. 1. Effect of diet, sulphonylurea, insulin or biguanide therapy on fasting plasma glucose and body weight. Diabetologia 24: 404?411","journal-title":"Diabetologia"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2337\/diab.32.11.1055","volume":"32","author":"G Boden","year":"1983","unstructured":"Boden G, Soriano M, Hoeldtke RD, Owen OE (1983) Counterregulatory hormone release and glucose recovery after hypoglycemia in non insulin-dependent diabetic patients. Diabetes 32: 1055?1059","journal-title":"Diabetes"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2337\/diab.33.11.1112","volume":"33","author":"KS Polonsky","year":"1984","unstructured":"Polonsky KS, Herold KC, Gilden JL, Bergenstal RM, Fang VS, Moosa AR, Jaspan JB (1984) Glucose counterregulation in patients after pancreatectomy: comparison with other clinical forms of diabetes. Diabetes 33: 1112?1119","journal-title":"Diabetes"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1172\/JCI111359","volume":"73","author":"GB Bolli","year":"1984","unstructured":"Bolli GB, Tsalikian E, Haymond MW, Cryer PE, Gerich JE (1984) Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. J Clin Invest 73: 1532?1541","journal-title":"J Clin Invest"},{"key":"CR10","first-page":"403","volume-title":"Autonomie failure. A textbook of clinical disorders of the autonomie nervous system","author":"T Bennett","year":"1983","unstructured":"Bennett T (1983) Physiological investigation of diabetic autonomie failure. In: Bannister R (ed) Autonomie failure. A textbook of clinical disorders of the autonomie nervous system. Oxford University Press, Oxford, pp 403?436"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2337\/diab.33.8.732","volume":"33","author":"GB Bolli","year":"1984","unstructured":"Bolli GB, DeFeo P, De Cosmo S, Perriello G, Ventura MM, Massa Benedetti M, Santeusanio F, Gerich JE, Brunetti P (1984) A reliable and reproducible test for adequate glucose counterregulation in type 1 diabetes mellitus. Diabetes 33: 732?737","journal-title":"Diabetes"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/clinchem\/24.10.1724","volume":"24","author":"B Lloyd","year":"1978","unstructured":"Lloyd B, Burin J, Smythe P, Alberti KGMM (1978) Enzymic flourimetric continuous-flow assays for blood glucose, lactate, alanine, glycerol and 3-hydroxybutyrate. Clin Chem 24: 1724?1729","journal-title":"Clin Chem"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2362.1976.tb00509.x","volume":"6","author":"RW Stout","year":"1976","unstructured":"Stout RW, Henry RW, Buchanan KD (1976) Triglyceride metabolism in acute starvation: the role of secretin and glucagon. Eur J Clin Invest 6: 179?185","journal-title":"Eur J Clin Invest"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/clinchem\/29.11.1923","volume":"29","author":"MMT O'Hare","year":"1983","unstructured":"O'Hare MMT, Daly JG, Buchanan KD (1983) Radioimmunoassay for pancreatic polypeptide, and it's age-related changes in concentration. Clin Chem 29: 1923?1927","journal-title":"Clin Chem"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bj0880137","volume":"88","author":"CN Hales","year":"1963","unstructured":"Hales CN, Randle PJ (1963) Immunoassay of insulin. Biochem J 88: 137?146","journal-title":"Biochem J"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0165-0270(85)90072-X","volume":"13","author":"IA Macdonald","year":"1985","unstructured":"Macdonald IA, Lake DM (1985) An improved technique for extracting catecholamines from body fluids. J Neurosci Methods 13: 239?248","journal-title":"J Neurosci Methods"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/BF01222104","volume":"11","author":"LG Heding","year":"1975","unstructured":"Heding LG (1975) Radioimmunological determinations of human C-peptide in serum. Diabetologia 11: 541?554","journal-title":"Diabetologia"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/clinchem\/29.2.340","volume":"29","author":"J Ambler","year":"1983","unstructured":"Ambler J, Walker G, Janik B (1983) Measurement of glycosylated haemoglobin on cellulose acetate membrane. Clin Chem 29: 240?243","journal-title":"Clin Chem"},{"key":"CR19","volume-title":"A General Statistical Program. Rothamstead Experimental Station","author":"Genstat","year":"1980","unstructured":"Genstat (1980) A General Statistical Program. Rothamstead Experimental Station. Numerical Algorithms Group Ltd, Oxford"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2337\/diab.26.1.36","volume":"26","author":"C Reynolds","year":"1977","unstructured":"Reynolds C, Molnar GD, Horwitz DL, Rubenstein AH, Taylor WF, Jiang NS (1977) Abnormalities of endogenous glucagon and insulin in unstable diabetes. Diabetes 26: 36?45","journal-title":"Diabetes"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF01223155","volume":"16","author":"LV Campbell","year":"1979","unstructured":"Campbell LV, Kraegen EW, Meler H, Lazarus L (1979) Hormonal responses to insulin infusion in diabetes mellitus. Diabetologia 16: 359?364","journal-title":"Diabetologia"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2337\/diab.28.11.1015","volume":"28","author":"NS Levitt","year":"1979","unstructured":"Levitt NS, Vinik AI, Sive AA, Child P, Jackson WPU (1979) Studies on plasma glucagon concentration in maturity-onset diabetics with autonomic neuropathy. Diabetes 28: 1015?1021","journal-title":"Diabetes"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1056\/NEJM198507253130405","volume":"313","author":"PE Cryer","year":"1985","unstructured":"Cryer PE, Gerich JE (1985) Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus. N Engl J Med 313: 232?241","journal-title":"N Engl J Med"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1136\/bmj.2.6101.1527","volume":"2","author":"LV Campbell","year":"1977","unstructured":"Campbell LV, Kraegen EW, Lazarus L (1977) Defective blood glucose counter-regulation in diabetics is a selective form of autonomie neuropathy. Br Med J 2: 1527?1529","journal-title":"Br Med J"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2337\/diabetes.26.3.196","volume":"26","author":"TD Maher","year":"1977","unstructured":"Maher TD, Tanenberg RJ, Greenberg BZ, Hoffman JE, Doe RP, Goetz FC (1977) Lack of glucagon response to hypoglycaemia in diabetic autonomie neuropathy. Diabetes 26: 196?200","journal-title":"Diabetes"},{"key":"CR26","series-title":"Glucagon","first-page":"133","volume-title":"Handbook of Pharmacology","author":"E Samols","year":"1983","unstructured":"Samols E, Weir G, Bonner-Weir S (1983) Intra-islet insulin-glucagon-somatostatin relationships. In: Lefebvre PJ (ed) Handbook of Pharmacology. Glucagon II, Springer, Berlin Heidelberg New York, pp 133?173"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2337\/diab.32.6.575","volume":"32","author":"RH Unger","year":"1983","unstructured":"Unger RH (1983) Insulin-glucagon relationships in the defence against hypoglycaemia. Diabetes 32: 575?583","journal-title":"Diabetes"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1172\/JCI111315","volume":"73","author":"G Bolli","year":"1984","unstructured":"Bolli G, De Feo P, Perriello G, De Cosmo S, Compagnucci P, Santeusanio F, Brunetti P, Unger RH (1984) Mechanisms of glucagon secretion during insulin-induced hypoglycaemia in man. Role of the beta cell and arterial hyperinsulinemia. J Clin Invest 73: 917?922","journal-title":"J Clin Invest"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2337\/diab.22.11.797","volume":"22","author":"KD Buchanan","year":"1973","unstructured":"Buchanan KD, Mawhinney WAA (1973) Glucagon release from isolated pancreas in streptozotocin treated rats. Diabetes 22: 797?800","journal-title":"Diabetes"},{"issue":"Suppl 1","key":"CR30","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0026-0495(76)80161-8","volume":"25","author":"E Samols","year":"1976","unstructured":"Samols E, Harrison J (1976) Intraislet negative insulin\/glucagon feedback. Metabolism 25 (Suppl 1): 1443?1447","journal-title":"Metabolism"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1172\/JCI111898","volume":"75","author":"MA Berk","year":"1985","unstructured":"Berk MA, Clutter WE, Skor D, Shah SD, Gingerich RP, Parvin CA, Cryer PE (1985) Enhanced glycemie responsiveness to epinephrine in insulin-dependent diabetes mellitus is the result of the inability to secrete insulin. J Clin Invest 75: 1842?1851","journal-title":"J Clin Invest"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1210\/jcem-50-3-445","volume":"50","author":"NS Levitt","year":"1980","unstructured":"Levitt NS, Vinik AI, Sive AA, Van Tonder S, Lund A (1980) Impaired pancreatic polypeptide responses to insulin induced hypoglycaemia in diabetic autonomie neuropathy. J Clin Endocrinol Metab 50: 445?449","journal-title":"J Clin Endocrinol Metab"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2337\/diab.29.8.600","volume":"29","author":"DE Gray","year":"1980","unstructured":"Gray DE, Lickley HLA, Vranic M (1980) Physiologic effects of epinephrine on glucose turnover and plasma free fatty acid concentrations mediated independently of glucagon. Diabetes 29: 600?608","journal-title":"Diabetes"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/S0016-5085(83)80027-4","volume":"85","author":"TW Schwartz","year":"1983","unstructured":"Schwartz TW (1983) Pancreatic polypeptide: a hormone under vagal control. Gastroenterology 85: 1411?1425","journal-title":"Gastroenterology"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0016-5085(80)90242-5","volume":"79","author":"AA Sive","year":"1980","unstructured":"Sive AA, Vinik AI, Levitt N, Van Tonder S (1980) Adrenergic modulation of human pancreatic polypeptide (hPP) release. Gastroenterology 79: 665?672","journal-title":"Gastroenterology"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00295875.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00295875\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00295875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T08:39:46Z","timestamp":1585903186000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00295875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1987,12]]}},"alternative-id":["BF00295875"],"URL":"https:\/\/doi.org\/10.1007\/bf00295875","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12]]}}}