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Experimentally, all dogs survived without hepatic insufficiency and systemic toxicity. Clinically, one patient died on postoperative day 14 of hepatic failure. The reason was that liver temperature reached 43\u00b0C, which seemed to be the maximum limit for thermal toxic effect to the human liver. The other six patients well tolerated the perfusion with mild increases of serum aminotransferase and total bilirubin levels and decreases of hepaprastin levels. Serum aminotransferase and total bilirubin and hepaprastin levels returned to normal levels by postoperative day 14. There were no significant differences between the isolated liver perfusion group (<jats:italic>n<\/jats:italic>=7) and hepatectomy\u2010only group (<jats:italic>n<\/jats:italic>=27). Six patients were discase\u2010free during the observation period after the perfusion. This system is a simple, useful method for treating patients with metastatic cancer limited to the liver.<\/jats:p>","DOI":"10.1007\/bf00299083","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T03:13:41Z","timestamp":1098242021000},"page":"845-850","source":"Crossref","is-referenced-by-count":16,"title":["Simple method of hyperthermo\u2010chemo\u2010hypoxic isolated liver perfusion for hepatic metastases"],"prefix":"10.1002","volume":"18","author":[{"given":"Masato","family":"Horikawa","sequence":"first","affiliation":[{"name":"First Department of Surgery Nara Medical University 840 Shijo\u2010cho, Kashihara 634 Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"First Department of Surgery Nara Medical University 840 Shijo\u2010cho, Kashihara 634 Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Kido","sequence":"additional","affiliation":[{"name":"First Department of Surgery Nara Medical University 840 Shijo\u2010cho, Kashihara 634 Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiho","family":"Ko","sequence":"additional","affiliation":[{"name":"First Department of Surgery Nara Medical University 840 Shijo\u2010cho, Kashihara 634 Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ohashi","sequence":"additional","affiliation":[{"name":"First Department of Surgery Nara Medical University 840 Shijo\u2010cho, Kashihara 634 Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshige","family":"Nakano","sequence":"additional","affiliation":[{"name":"First Department of Surgery Nara Medical University 840 Shijo\u2010cho, Kashihara 634 Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"610","article-title":"Hepatic resection for secondary neoplasms","volume":"92","author":"Morrow C.E.","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198502000-00013"},{"key":"e_1_2_1_4_1","first-page":"804","article-title":"Liver resection for metastatic colorectal cancer","volume":"100","author":"Iwatuki S.","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_1_5_1","first-page":"278","article-title":"Resection of the liver for colorectal carcinoma metastasis: a multi\u2010institutional study of patterns of recurrence","volume":"100","author":"Hughes K.S.","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198502000-00012"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(87)90784-7"},{"key":"e_1_2_1_8_1","first-page":"13","article-title":"Indicators of prognosis after hepatic resection for colorectal secondaries","volume":"110","author":"Scheele J.","year":"1991","journal-title":"Surgery"},{"key":"e_1_2_1_9_1","first-page":"77","article-title":"The technique of liver perfusion","volume":"10","author":"Aust J.B.","year":"1960","journal-title":"Cancer Chemother. 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