{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:17:22Z","timestamp":1762100242369},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1994,11,1]],"date-time":"1994-11-01T00:00:00Z","timestamp":783648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary hyperparathyroidism was investigated using the presence of basic fibroblast growth factor (bFGF) from the immunohistochemical viewpoint with an anti\u2010bFGF antibody in hyperplastic parathyroid glands of patients with multiple endocrine neoplasia type I (MEN\u2010I) and of patients with non\u2010MEN. The results corresponded well with the data from the DNA analysis. Twenty\u2010five hyperplastic parathyroid glands from 11 patients with MEN\u2010I and 38 glands from 20 patients with non\u2010MEN primary hyperparathyroidism were stained immunohistochemically according to the avidin\u2010biotin\u2010peroxidase complex procedure. When 50% or more of the cells appeared uniformly stained, it was judged positively stained. In addition, 18 hyperplastic parathyroid glands from patients with MEN\u2010I patients and 24 hyperplastic parathyroid glands from non\u2010MEN patients were also analyzed for DNA using flow cytometry. The ratio of positively stained hyperplastic parathyroid glands was 72% in MEN\u2010I patients and 18% in non\u2010MEN patients. The difference between the two groups was significant (<jats:italic>p<\/jats:italic>&lt;0.01). The nodules consisted of oxyphilic cells in 7 of 25 hyperplastic parathyroid glands from MEN\u2010I patients and in 10 of 38 hyperplastic parathyroid glands from non\u2010MEN patients, and all the cells were positive for bFGF. There was no significant correlation between bFGF staining and the DNA ploidy pattern. bFGF possibly plays a role in the development of parathyroid gland hyperplasia, especially in MEN\u2010I patients. The increase of oxyphilic cells may be correlated with the expression of bFGF.<\/jats:p>","DOI":"10.1007\/bf00299109","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T03:13:41Z","timestamp":1098242021000},"page":"921-924","source":"Crossref","is-referenced-by-count":5,"title":["Expression of basic fibroblast growth factor in hyperplastic parathyroid glands from patients with multiple endocrine neoplasia type I"],"prefix":"10.1002","volume":"18","author":[{"given":"Makoto","family":"Komatsu","sequence":"first","affiliation":[{"name":"Department of Surgery Fujimi\u2010kogen Hospital 11100 Ochiai, Fujimi\u2010machi, Suwa\u2010gun 399\u201002 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagano Cancer Detection Center Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagano Cancer Detection Center Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayuri","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pathology Okaya\u2010enrei Hospital Okaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Okaya\u2010enrei Hospital Okaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pathology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoshi","family":"Hanamura","sequence":"additional","affiliation":[{"name":"Department of Surgery Okaya\u2010enrei Hospital Okaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyuki","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Surgery Okaya\u2010enrei Hospital Okaya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takai","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Surgery Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605153142004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-1-149"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907273210402"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-1-149"},{"key":"e_1_2_1_6_1","first-page":"639","article-title":"A novel endothelial cell growth factor circulates in familial multiple endocrine neoplasia type I","volume":"17","author":"Brandi M.L.","year":"1990","journal-title":"Nucl. 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