{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:57:39Z","timestamp":1765666659280},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1995,5,1]],"date-time":"1995-05-01T00:00:00Z","timestamp":799286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eighteen patients with postoperative fistulas of the gastrointestinal tract were treated with the somatostatin analog octreotide between November 1989 and November 1992. Fourteen patients had enterocutaneous fistulas: seven from the duodenum and seven from the ileum. Another three patients had pancreatic fistulas, and one patient had a biliary fistula. Within 24 hours of octreotide treatment, a mean reduction of 52% in the intestinal fistulas' output, 40% in the pancreatic fistulas, and 30% in the biliary fistula was noted. In the intestinal fistulas group the closure rate was 72% after a mean of 11\u00a0days. Early closure (mean 6\u00a0days) was achieved in all three pancreatic fistulas. In the patient with the biliary fistula a 30% reduction was observed twice following the administration of octreotide, and an increase occurred when it was withheld. The reduction rate of the secretions in high\u2010output intestinal fistulas (&gt;500\u00a0ml\/day) was higher than in the low\u2010output fistulas (63\u00b18% versus 39\u00b14%, <jats:italic>p<\/jats:italic>&lt;0.05). Fistula output and the initial response to octreotide treatment had no value in predicting spontaneous healing. In conclusion, octreotide is a valuable tool for the conservative treatment of fistulas of the digestive tract. It is especially valuable for management of high\u2010output enteric fistulas and pancreatic fistulas.<\/jats:p>","DOI":"10.1007\/bf00299182","type":"journal-article","created":{"date-parts":[[2004,10,6]],"date-time":"2004-10-06T17:14:42Z","timestamp":1097082882000},"page":"430-433","source":"Crossref","is-referenced-by-count":32,"title":["Octreotide for treatment of postoperative alimentary tract fistulas"],"prefix":"10.1002","volume":"19","author":[{"given":"Haim","family":"Paran","sequence":"first","affiliation":[{"name":"Department of Surgery A Meir Hospital Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Neufeld","sequence":"additional","affiliation":[{"name":"Department of Surgery A Meir Hospital Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Surgery B Sourasky Tel\u2010Aviv Medical Center Tel\u2010Aviv University Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Klausner","sequence":"additional","affiliation":[{"name":"Department of Surgery B Sourasky Tel\u2010Aviv Medical Center Tel\u2010Aviv University Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Freund","sequence":"additional","affiliation":[{"name":"Department of Surgery A Meir Hospital Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"345","article-title":"One hundred and fourteen fistulas of the gastrointestinal tract treated with total parenteral nutrition","volume":"163","author":"Rose D.","year":"1986","journal-title":"Surg. 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