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The control group consisted of 81 patients with advanced gastric cancer who underwent curative surgery during the same period. CHPP was performed for 60\u00a0minutes by perfusing MMC\u2010 and CDDP\u2010containing saline solutions warmed at 43.5\u00b0C by a special CHPP device. In patients with pathologically confirmed serosal invasion\u2010positive tumors, the survival rate of the CHPP group was significantly higher than that of the control group. A survival advantage for stage IV patients was also obtained by CHPP. However, there was no survival advantage between the CHPP group and the control group with serosal invasion\u2010negative tumors. Adverse effects were observed in four patients who underwent CHPP: One developed severe bone marrow suppression, and transient hyperazotemia was ebserved in the other three. There was no difference in the incidence of mortality and morbidity between the two groups. These results indicate that CHPP is a safe, readily available prophylactic therapy for peritoneal recurrence after gastric cancer surgery.<\/jats:p>","DOI":"10.1007\/bf00299188","type":"journal-article","created":{"date-parts":[[2004,10,6]],"date-time":"2004-10-06T17:14:42Z","timestamp":1097082882000},"page":"450-454","source":"Crossref","is-referenced-by-count":95,"title":["Prophylaxis with intraoperative chemohyperthermia against peritoneal recurrence of serosal invasion\u2010positive gastric cancer"],"prefix":"10.1002","volume":"19","author":[{"given":"Y.","family":"Yonemura","sequence":"first","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kaji","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sawa","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Katayama","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Hirono","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Miwa","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine Kanazawa University Takara\u2010Machi 13\u20101 Kanazawa City Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"51","volume-title":"Gastric Carcinogenesis","author":"Munoz N.","year":"1988"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658714"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1989.01410030049009"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655804"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1989.01410090071015"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90792-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658939"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.9.1318"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01675656"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750209"},{"key":"e_1_2_1_12_1","first-page":"222","article-title":"Surgical treatment of advanced gastric cancer with metastasis in para\u2010aortic lymph node","volume":"76","author":"Yonemura Y.","year":"1991","journal-title":"Int. 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