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Despite the deficiency of donor organs, a single center experience with 198 patients reveals that liver transplantation continues its role as a therapeutic option for selected patients. At present \u201cfavorable\u201d indications for transplantation are International Union against Cancer (UICC)\u2010stage II hepatocellular carcinoma as well as the subtype fibrolamellar carcinoma, uncommon tumors such as epitheloid hemangioendothelioma, hepatoblastoma, and liver metastases from neuroendocrine tumors. Due to unsatisfying results, intrahepatic bile duct\u2010, stage III and IV hepatocellular carcinoma, hemangiosarcoma, and liver metastases from nonendocrine primaries should be excluded from liver transplantation alone. For these advanced tumors, especially in cases of extrahepatic involvement, a combination of liver transplantation and multivisceral resection has been proven feasible. However, a significant improvement in patient survival may only be expected by currently investigated multimodality treatment protocols which will require further randomized studies.<\/jats:p>","DOI":"10.1007\/bf00299775","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T03:24:43Z","timestamp":1102649083000},"page":"807-813","source":"Crossref","is-referenced-by-count":129,"title":["Role of liver transplantation in the treatment of unresectable liver cancer"],"prefix":"10.1002","volume":"19","author":[{"given":"Rudolf","family":"Pichlmayr","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Abdominal\u2010 und Transplantationschirurgie Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arved","family":"Weimann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Abdominal\u2010 und Transplantationschirurgie Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl J.","family":"Oldhafer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Abdominal\u2010 und Transplantationschirurgie Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J.","family":"Schlitt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Abdominal\u2010 und Transplantationschirurgie Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Klempnauer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Abdominal\u2010 und Transplantationschirurgie Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Bornscheuer","sequence":"additional","affiliation":[{"name":"Abteilung An\u00e4sthesie I Medizinische Hochschule Hannover Konstanty\u2010Gutschow Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Chavan","sequence":"additional","affiliation":[{"name":"Abteilung H\u00e4matologie und Onkologie Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekkehard","family":"Schmoll","sequence":"additional","affiliation":[{"name":"Abteilung Diagnostiche Radiologie I Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke","family":"Lang","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Abdominal\u2010 und Transplantationschirurgie Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Tusch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Abdominal\u2010 und Transplantationschirurgie Medizinische Hochschule Hannover Konstanty\u2010Gutschow\u2010Strasse 8 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burckhardt","family":"Ringe","sequence":"additional","affiliation":[{"name":"Abteilung Transplantationschirurgie Georg\u2010August\u2010Universit\u00e4t Robert\u2010Koch\u2010Strasse 40 37075 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,11]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"TNM classification of malignant tumors","author":"Hermanek P.","year":"1992"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199403000-00003"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686661"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686662"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2604-9_19"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316984"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316981"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199408000-00012"},{"key":"e_1_2_1_10_1","first-page":"454","article-title":"Hepatic resection with ischemia of the liver exceeding one hour","volume":"178","author":"Huguet C.","year":"1994","journal-title":"J. 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