{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:03:01Z","timestamp":1705017781203},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently developed a new model for rapid and reproducible induction of biliary carcinoma in hamsters. In the present study, we evaluated the effects of cholecystokinin (CCK), which has a trophic action on the gastrointestinal tract and on the pancreaticobiliary system, on biliary carcinogenesis in this hamster model. Hamsters treated with N\u2010nitrosobis (2\u2010oxopropyl) amine (BOP) were divided into four groups: In Group I, hydrolyzed gelatin, a solvent of CCK, was injected subcutaneously. In Groups II and III, CCK 2.5 and 25 \u03bcg\/kg were administered, respectively. In Groups IV loxiglumide, a CCK receptor antagonist, was administered. CCK significantly promoted the carcinogenetic effect of GOP in the intra\u2010 and extrahepatic bile ducts but not in the gallbladder or pancreas. Loxiglumide exerted an inhibitory effect on carcinogenesis in the intrahepatic bile duct.<\/jats:p>","DOI":"10.1007\/bf00299782","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T03:24:43Z","timestamp":1102649083000},"page":"847-850","source":"Crossref","is-referenced-by-count":4,"title":["Enhancement of biliary carcinogenesis in hamsters by cholecystokinin"],"prefix":"10.1002","volume":"19","author":[{"given":"Yoshito","family":"Ikematsu","sequence":"first","affiliation":[{"name":"Second Department of Surgery Nagasaki University School of Medicine 1\u20107\u20101 Sakamoto 852 Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Second Department of Surgery Nagasaki University School of Medicine 1\u20107\u20101 Sakamoto 852 Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitsugu","family":"Tajima","sequence":"additional","affiliation":[{"name":"Second Department of Surgery Nagasaki University School of Medicine 1\u20107\u20101 Sakamoto 852 Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Second Department of Surgery Nagasaki University School of Medicine 1\u20107\u20101 Sakamoto 852 Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kanematsu","sequence":"additional","affiliation":[{"name":"Second Department of Surgery Nagasaki University School of Medicine 1\u20107\u20101 Sakamoto 852 Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02471720"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/60.2.283"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000197659"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(82)80330-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)91572-2"},{"key":"e_1_2_1_7_1","first-page":"2438","article-title":"Modulation by CR\u20101409 (Lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor\u2010enhanced growth of azacerine\u2010induced putative preneoplastic lesions in rat pancreas","volume":"49","author":"Douglas B.R.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198909000-00007"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1994.tb02948.x"},{"issue":"714","key":"e_1_2_1_10_1","article-title":"Interaction of caerulein and secretin on pancreatic size and composition in rat","volume":"235","author":"Solomon T.E.","year":"1978","journal-title":"Am. 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