{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:06:01Z","timestamp":1760979961683,"version":"3.32.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fourteen patients with liver tumor malignancy and sixteen patients with malignant melanoma localized to one limb were studied regarding leukocyte activation with the release of polymorphonuclear neutrophilic (PMN) elastase and of neopterin and formation of cytokines (TNF\u2010\u03b1 and Il\u20106) during the surgical treatment. Patients undergoing liver resection (<jats:italic>n<\/jats:italic>=10), abdominal hysterectomy (<jats:italic>n<\/jats:italic>=10), or hip replacement surgery (<jats:italic>n<\/jats:italic>=10) served as control groups. Isolated hyperthermic liver perfusion was performed with cytostatic\u2010containing perfusate (melphalan and cisplatinum). Patients with recurrent malignant melanoma confined to one limb underwent isolated hyperthermic limb perfusion with cytostatic\u2010containing perfusate (melphalan). Blood samples for determination of PMN elastase, neopterin, TNF\u2010\u03b1, and IL\u20106 were drawn from the patients preoperatively, 1\u00a0minute before the start of the perfusion, 60 and 120\u00a0minutes after the start of the perfusion, and 24 hours postoperatively. Samples from the perfusate were drawn 60\u00a0minutes after the start of the perfusion. High concentrations of plasma PMN clastase were found both in patients undergoing liver and limb perfusion and in patients undergoing liver resection surgery. Elevated concentrations of Il\u20106 were found in the patients undergoing liver perfusion and in patients undergoing liver resection. In none of the patients were there increased concentrations of neopterin or TNF\u2010\u03b1. The perfusate contained high concentrations of PMN elastase, neopterin, and IL\u20106. This study also demonstrated that major surgery leads to elevated concentrations of PMN elastase and IL\u20106. An increase of PMN elastase and IL\u20106 was seen in response to perfusion and to surgical trauma.<\/jats:p>","DOI":"10.1007\/bf00299787","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T03:24:43Z","timestamp":1102649083000},"page":"861-866","source":"Crossref","is-referenced-by-count":3,"title":["Leukocyte activation by isolated hyperthermic liver and limb perfusion due to malignancy"],"prefix":"10.1002","volume":"19","author":[{"given":"Jan Petter","family":"Arnestad","sequence":"first","affiliation":[{"name":"Department of Anesthesiology &amp; Intensive Care Sahlgrenska University Hospital S\u201041345 G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Intensive Care Sahlgrenska University Hospital S\u201041345 G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Peter","family":"Bengtson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Intensive Care Sahlgrenska University Hospital S\u201041345 G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larsolof","family":"Hafstrom","sequence":"additional","affiliation":[{"name":"Department of Surgery Ume\u00e5 University Hospital S\u201090400 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Redl","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology A\u20101300 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther","family":"Schlag","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology A\u20101300 Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,11]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Ausman R.K. 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