{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:45:17Z","timestamp":1751031917179},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1981,12,1]],"date-time":"1981-12-01T00:00:00Z","timestamp":376012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[1981,12]]},"DOI":"10.1007\/bf00313378","type":"journal-article","created":{"date-parts":[[2004,10,10]],"date-time":"2004-10-10T16:51:27Z","timestamp":1097427087000},"page":"169-179","source":"Crossref","is-referenced-by-count":8,"title":["Identification of the ? and ? light chains within the CSF immunoglobulin region in multiple sclerosis and subacute sclerosing panencephalitis by immunofixation after isoelectric focusing"],"prefix":"10.1007","volume":"226","author":[{"given":"B.","family":"Rocchelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Poloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mazzarello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Delodovici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00329158","volume":"212","author":"F Bollengier","year":"1976","unstructured":"Bollengier F, Delmotte P, Lowenthal A (1976) Biochemical findings in multiple sclerosis, part 3. (Immunoglobulins of restricted heterogeneity and light chain distribution in cerebrospinal fluid of patients with multiple sclerosis.) J Neurol 212:151?158","journal-title":"J Neurol"},{"key":"CR2","first-page":"226","volume":"72","author":"P Delmotte","year":"1972","unstructured":"Delmotte P (1972) Comparative results of agar-electrophoresis and isoelectric focusing examination of the gamma-globulins of the cerebrospinal fluid. Acta Neurol Belg 72:226?234","journal-title":"Acta Neurol Belg"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00312547","volume":"215","author":"P Delmotte","year":"1977","unstructured":"Delmotte P, Gonsette R (1977) Biochemical findings in multiple sclerosis. Isoelectric focusing of the CSF gamma-globulins in multiple sclerosis (262 cases) and other neurological diseases (272 cases). J Neurol 215:27?37","journal-title":"J Neurol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/jcp.23.7.586","volume":"23","author":"C Fossard","year":"1970","unstructured":"Fossard C, Dale G, Latner AL (1970) Separation of proteins of cerebrospinal fluid using gel-electrofocusing followed by electrophoresis. J Clin Path 23:586?589","journal-title":"J Clin Path"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0022-510X(74)90223-8","volume":"23","author":"KG Kjellin","year":"1974","unstructured":"Kjellin KG, Vesterberg O (1974) Isoelectric focusing of CSF proteins in neurological diseases. J Neurol Sci 23:199?213","journal-title":"J Neurol Sci"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1001\/archneur.1980.00500580033003","volume":"37","author":"KP Johnson","year":"1980","unstructured":"Johnson KP, Likowsky WH, Nelson BJ, Fein G (1980) Comprehensive viral immunology of multiple sclerosis. I. Clinical, epidemiological and CSF studies. Arch Neurol 37:537?541","journal-title":"Arch Neurol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1212\/WNL.20.10.982","volume":"20","author":"EC Laterre","year":"1970","unstructured":"Laterre EC, Callewaert A, Heremans JF, Sfaello Z (1970) Electrophoretic morphology of gamma-globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system. Neurology 20:982?990","journal-title":"Neurology"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1600-0404.1978.tb02874.x","volume":"58","author":"MA Laurenzi","year":"1978","unstructured":"Laurenzi MA, Link H (1978) Comparison between agarose gel electrophoresis and isoelectric focusing of CSF for demonstration of oligoclonal immunoglobulin bands in neurological disorders. Acta Neurol Scand 58:148?156","journal-title":"Acta Neurol Scand"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ana.410080304","volume":"8","author":"MA Laurenzi","year":"1980","unstructured":"Laurenzi MA, Mavra M, Kam-Hansen S, Link H (1980) Oligoclonal IgG and free light chains in multiple sclerosis demonstrated by thin layer polyacrylamide gel isoelectric focusing and immunofixation. Ann Neurol 8:241?247","journal-title":"Ann Neurol"},{"issue":"28","key":"CR10","first-page":"1","volume":"43","author":"H Link","year":"1967","unstructured":"Link H (1967) Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid: chemical and immunological characterisation with special reference to multiple sclerosis. Acta Neurol Scand 43 (Suppl 28): 1?136","journal-title":"Acta Neurol Scand"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0009-8981(73)90251-9","volume":"46","author":"H Link","year":"1973","unstructured":"Link H (1973) Comparison of electrophoresis on agar-gel and agarose-gel in the evaluation of gamma-globulin abnormalities in cerebrospinal fluid and serum in multiple sclerosis. Clin Chim Acta 46:383?389","journal-title":"Clin Chim Acta"},{"key":"CR12","first-page":"435","volume":"6","author":"H Link","year":"1970","unstructured":"Link H, Zettervall O (1970) Multiple sclerosis: disturbed k\/? chain ratio of immunoglobulin G in cerebrospinal fluid. Clin Exp Immunol 6:435?438","journal-title":"Clin Exp Immunol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/archneur.1971.00490040052007","volume":"25","author":"H Link","year":"1971","unstructured":"Link H, Muller R (1971) Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch Neurol 25:326?344","journal-title":"Arch Neurol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ana.410060205","volume":"6","author":"H Link","year":"1979","unstructured":"Link H, Laurenzi MA (1979) Immunoglobulin class and light chain type of oligoclonal bands in CSF in multiple sclerosis determined by agarose gel electrophoresis and immunofixation. Ann Neurol 6:107?110","journal-title":"Ann Neurol"},{"key":"CR15","first-page":"501","volume":"33","author":"P Livrea","year":"1978","unstructured":"Livrea P, Zimatore GB, Simone IL, Lepore V, Trojano M, Loreto M, De Blasi A, Gennarini GF (1978) Isoelectric focusing and crossed-immunoelectrofocusing of cerebrospinal fluid proteins in neurological disorders. Acta Neurol 33:501?517","journal-title":"Acta Neurol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00313278","volume":"224","author":"P Livrea","year":"1981","unstructured":"Livrea P, Trojano M, Simone IL, Zimatore GB, Lamontanara G, Leante R (1981) Intrathecal IgG synthesis in multiple sclerosis: comparison between isoelectric focusing and quantitative estimation of cerebrospinal fluid IgG. J Neurol 224:159?169","journal-title":"J Neurol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1471-4159.1960.tb13448.x","volume":"6","author":"A Lowenthal","year":"1960","unstructured":"Lowenthal A, Van Sande M, Karcher D (1960) The differential diagnosis of neurological diseases by fractionating electrophoretically the CSF ?-globulins. J Neurochem 6:51?56","journal-title":"J Neurochem"},{"key":"CR18","volume-title":"Agar gel electrophoresis in neurology","author":"A Lowenthal","year":"1964","unstructured":"Lowenthal A (1964) Agar gel electrophoresis in neurology. Elsevier Publishing Company, Amsterdam"},{"key":"CR19","first-page":"549","volume":"29","author":"RH Mattson","year":"1979","unstructured":"Mattson RH, Roos RP, Arnason BGW (1979) Comparison of agar gel electrophoresis and isoelectric focusing in subacute sclerosing panencephalitis, multiple sclerosis and other demyelinating diseases. Neurology 29:549","journal-title":"Neurology"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.4049\/jimmunol.118.6.2254","volume":"118","author":"PD Mehta","year":"1977","unstructured":"Mehta PD, Kane A, Thormar H (1977) Quantitation of measles virus specific immunoglobulins in serum, CSF and brain extract from patients with subacute sclerosing panencephalitis. J Immunol 118:2254?2261","journal-title":"J Immunol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/archneur.1980.00500590031002","volume":"37","author":"PD Mehta","year":"1980","unstructured":"Mehta PD, Thormar H, Wisniewski HM (1980) Quantitation of measles-specific IgG. Its presence in CSF and brain extracts of patients with multiple sclerosis. Arch Neurol 37:607?609","journal-title":"Arch Neurol"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1212\/WNL.24.3.211","volume":"24","author":"T Ohya","year":"1974","unstructured":"Ohya T, Julio Martinez A, Jabbour JT, Lemmi H, Duenas DA (1974) Subacute sclerosing panencephalitis. Neurology 24:211?218","journal-title":"Neurology"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1600-0404.1976.tb04350.x","volume":"53","author":"JE Olsson","year":"1976","unstructured":"Olsson JE, Petterson B (1976) A comparison between agar gel electrophoresis and CSF and serum quotients of IgG and albumin in neurological diseases. Acta Neurol Scand 53:308?322","journal-title":"Acta Neurol Scand"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1212\/WNL.29.10.1383","volume":"29","author":"JE Olsson","year":"1979","unstructured":"Olsson JE, Nilsson K (1979) Gamma globulins of CSF and serum in multiple sclerosis: isoelectric focusing on polyacrylamide gel and agar gel electrophoresis. Neurology 29:1383?1391","journal-title":"Neurology"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0009-8981(79)90430-3","volume":"96","author":"JM Perini","year":"1979","unstructured":"Perini JM, Lebas J, Roussel P, Biserte G (1979) Evidence for heterogeneous or incomplete immunoglobulins in oligoclonal CSF studied by electroimmunofixation. Clin Chim Acta 96:205?214","journal-title":"Clin Chim Acta"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00314641","volume":"221","author":"M Poloni","year":"1979","unstructured":"Poloni M, Rocchelli B, Scelsi R, Pinelli P (1979) Intrathecal IgG synthesis in multiple sclerosis and other neurological diseases: a comparative evaluation by IgG-index and isoelectric focusing. J Neurol 221:245?255","journal-title":"J Neurol"},{"key":"CR27","volume-title":"Neurochemistry and clinical neurology, vol 39, art 135-27","author":"M Poloni","year":"1980","unstructured":"Poloni M, Rocchelli B, Rosano Burgio F, Besana D, Lanzi G (1980) Isoelectric focusing in CSF examination during subacute sclerosing panencephalitis. In: Neurochemistry and clinical neurology, vol 39, art 135-27. Alan Liss Inc, New York"},{"key":"CR28","first-page":"69","volume":"127","author":"B Rocchelli","year":"1980","unstructured":"Rocchelli B, Poloni M, Mazzarello P (1980) Analyse comparative des param\ufffdtres quantitatifs et qualitatifs de synth\ufffdse intrath\ufffdcale d'IgG en cours de scl\ufffdrose en plaques et d'autres aff\ufffdctions neurologiques. Archives Suisses de Neurologie Neurochirurgie et de Psychiatrie 127:69?77","journal-title":"Archives Suisses de Neurologie Neurochirurgie et de Psychiatrie"},{"key":"CR29","first-page":"522","volume":"122","author":"GA Schumacher","year":"1965","unstructured":"Schumacher GA, Beebe G, Kibler RF, Kurland LT, Kurtzke JF, McDowell F, Nagler B, Sibley WA, Tourtellotte WW, Willman TL (1965) Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann NY Acad Sci 122:522?568","journal-title":"Ann NY Acad Sci"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0022-510X(78)90194-6","volume":"39","author":"A Sid\ufffdn","year":"1978","unstructured":"Sid\ufffdn A, Kjellin KG (1978) CSF proteins examination with thin-layer isoelectric focusing in multiple sclerosis. J Neurol Sci 39:131?146","journal-title":"J Neurol Sci"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0022-510X(79)90059-5","volume":"42","author":"H Stibler","year":"1979","unstructured":"Stibler H (1979) Direct immunofixation after isoelectric focusing: an improved method for identification of cerebrospinal fluid and serum proteins. J Neurol Sci 42:275?281","journal-title":"J Neurol Sci"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1212\/WNL.28.9_Part_2.76","volume":"28","author":"WW Tourtellotte","year":"1978","unstructured":"Tourtellotte WW, Booe I (1978) Multiple sclerosis: the blood-brain-barrier and the measurement of de novo central nervous system IgG synthesis. Neurology 28:76?83","journal-title":"Neurology"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1365-3083.1977.tb00412.x","volume":"6","author":"B Vandvik","year":"1977","unstructured":"Vandvik B (1977) Oligoclonal IgG and free light chains in the cerebrospinal fluid of patients with multiple sclerosis and infectious diseases of the central nervous system. Scand J Immunol 6:913?922","journal-title":"Scand J Immunol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1073\/pnas.70.4.1060","volume":"70","author":"B Vandvik","year":"1973","unstructured":"Vandvik B, Norrby E (1973) Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci 70:1060?1063","journal-title":"Proc Natl Acad Sci"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000114228","volume":"9","author":"B Vandvik","year":"1973","unstructured":"Vandvik B, Skrede S (1973) Electrophoretic examination of cerebrospinal fluid proteins in multiple sclerosis and other neurological diseases. Eur Neurol 9:224?241","journal-title":"Eur Neurol"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-3083.1976.tb00297.x","volume":"5","author":"B Vandvik","year":"1976","unstructured":"Vandvik B, Natvig JB, Wiger D (1976) IgG1 subclass restriction of oligoclonal IgG from cerebrospinal fluid and brain extracts in patients with multiple sclerosis and subacute encephalitides. Scand J Immunol 5:427?436","journal-title":"Scand J Immunol"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1365-3083.1976.tb03050.x","volume":"5","author":"B Vandvik","year":"1976","unstructured":"Vandvik B, Norrby E, Nordal HJ, Degr\ufffd M (1976) Oligoclonal measles virus-specific IgG antibodies isolated from cerebrospinal fluids, brain extracts and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis. Scand J Immunol 5:979?992","journal-title":"Scand J Immunol"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1365-3083.1977.tb02145.x","volume":"6","author":"B Vandvik","year":"1977","unstructured":"Vandvik B, Natvig JB, Norrby E (1977) IgG1 subclass restriction of oligoclonal measles virus specific IgG antibodies in patients with subacute sclerosing panencephalitis and in a patient with multiple sclerosis. Scand J Immunol 6:651?657","journal-title":"Scand J Immunol"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ana.410080305","volume":"8","author":"F Vartdal","year":"1980","unstructured":"Vartdal F, Vandvik B, Norrby E (1980) Viral and bacterial antibody responses in multiple sclerosis. Ann Neurol 8:248?255","journal-title":"Ann Neurol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00313378.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00313378\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00313378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T14:19:43Z","timestamp":1682777983000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00313378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,12]]}},"alternative-id":["BF00313378"],"URL":"https:\/\/doi.org\/10.1007\/bf00313378","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,12]]}}}