{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:12:55Z","timestamp":1785327175658,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[1994,4]]},"DOI":"10.1007\/bf00313606","type":"journal-article","created":{"date-parts":[[2004,10,10]],"date-time":"2004-10-10T17:09:29Z","timestamp":1097428169000},"page":"371-376","source":"Crossref","is-referenced-by-count":14,"title":["Mitochondrial myopathy: correlation between oxidative defect and mitochondrial DNA deletions at single fiber level"],"prefix":"10.1007","volume":"87","author":[{"given":"A.","family":"Prelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fagiolari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Checcarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Moggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Battistel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.P.","family":"Comi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bordoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zeviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Scarlato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ana.410210607","volume":"21","author":"N Bresolin","year":"1986","unstructured":"Bresolin N, Moggio M, Bet L, Gallanti A, Prelle A, Nobile-Orazio E, Adobbati L, Ferrante C, Pellegrini G, Scarlato G (1986) Progressive cytochrome c oxidase deficiency in a case of Kearns-Sayre syndrome: morphological, immunological, and biochemical studies in muscle biopsies and autopsy tissues. Ann Neurol 21: 564?572","journal-title":"Ann Neurol"},{"key":"CR2","first-page":"317","volume":"309","author":"S Collins","year":"1991","unstructured":"Collins S, Rudduck C, Marzuki S, Dennett X, Byrne E (1991) Mitochondrial genome distribution in histochemically cytochrome c oxidase-negative fibres in patients with a mixture of deleted and wild-type mitochondrial DNA. Biochim Biophys Acta 309: 317","journal-title":"Biochim Biophys Acta"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ana.410170602","volume":"17","author":"S Mauro Di","year":"1985","unstructured":"Di Mauro S, Bonilla E, Zeviani M, Nagagawa M, DeVivo DC (1985) Mitochondrial myopathies. Ann Neurol 17: 521?538","journal-title":"Ann Neurol"},{"key":"CR4","volume-title":"Muscle Biopsy: a practical approach","author":"V Dubowitz","year":"1985","unstructured":"Dubowitz V (1985) Muscle Biopsy: a practical approach. Balliere Tindall, London"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/brain\/115.2.343","volume":"115","author":"SR Hammans","year":"1992","unstructured":"Hammans SR, Sweeney MG, Wicks DAG, Morgan-Hughes JA, Harding AE (1992) A molecular genetic study of focal histochemical defects in mitochondrial encephalomyopathies. Brain 115: 343?365","journal-title":"Brain"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/331717a0","volume":"331","author":"J Holt","year":"1988","unstructured":"Holt J, Harding AE, Morgan-Hughes JA (1988) Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331: 717?719","journal-title":"Nature"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"8269","DOI":"10.1016\/S0021-9258(17)34391-0","volume":"253","author":"C Lowry","year":"1978","unstructured":"Lowry C, Kimmey JS, Felder S, Chi MMY, Kaiser K, Passoneau PN, Kirk KA, Lowry OH (1978) Enzyme patterns in single human muscle fibers. J Biol Chem 253: 8269?8277","journal-title":"J Biol Chem"},{"key":"CR8","volume-title":"Molecular Cloning: a laboratory manual","author":"T Maniatis","year":"1982","unstructured":"Maniatis T (1982) Molecular Cloning: a laboratory manual. Cold Spring Habor Laboratory Press, Cold Spring Habor"},{"key":"CR9","first-page":"9509","volume":"86","author":"S Mita","year":"1989","unstructured":"Mita S, Schmidt B, Schon EA, DiMauro S, Bonilla E (1989) Detection of ?deleted? mitochondrial genomes in cytochrome c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome. Med Sci 86: 9509?9513","journal-title":"Med Sci"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJM198905183202001","volume":"320","author":"CT Moraes","year":"1989","unstructured":"Moraes CT, Di Mauro S, Zeviani M, Lombes A, Shanske S, Miranda AF, Nakase H, Bonilla E, Werneck LC, Servidei S, Nonaka I, Koga Y, Spiro AJ, Brownell AKW, Schotland DL, Zupanc M, De Vivo D, Schmidt B, Schon EA, Rowland LP (1989) Mitochondrial DNA deletions progressive external ophthalmoplegia and Kearns-Sayre syndrome. N Engl J Med 320: 1293?1299","journal-title":"N Engl J Med"},{"issue":"5","key":"CR11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/ng0892-359","volume":"1","author":"CT Moraes","year":"1992","unstructured":"Moraes CT, Ricci E, Petruzzella V, Shanske S, Di Mauro S, Schon EA, Bonilla E (1992) Molecular analysis of the muscle pathology associated with mitochondrial DNA deletions. Nature Genet 1 (5): 359?367","journal-title":"Nature Genet"},{"key":"CR12","first-page":"418","volume":"46","author":"H Nakase","year":"1990","unstructured":"Nakase H, Moares CT, Rizzuto R, Lombes A, DiMauro S, Schon EA (1990) Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis. Am J Hum Genet 46: 418?427","journal-title":"Am J Hum Genet"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archneur.1972.00490090019001","volume":"26","author":"W Olson","year":"1972","unstructured":"Olson W, Engel WK, Walsh GO, Einaugler R (1972) Oculocraniosomatic neuromuscular disease with ?ragged red? fibers: histochemical and ultrastructural changes in limb muscles of a group of patients with idiopathic progressive external ophthalmoplegia. Arch Neurol 26: 193","journal-title":"Arch Neurol"},{"key":"CR14","first-page":"177","volume":"169","author":"A Oldfors","year":"1992","unstructured":"Oldfors A, Larsson NG, Holme E, Tulinius M, Kadenbach B, Droste M (1992) Mitochondrial DNA deletion and cytochrome c oxidase deficiency in muscle fibers. J Neurol Sci 169: 177","journal-title":"J Neurol Sci"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/brain\/109.5.915","volume":"109","author":"RHK Petty","year":"1986","unstructured":"Petty RHK, Harding AE, Morgan-Huges JA (1986) The clinical features of mitochondrial myopathies. Brain 109: 915?938","journal-title":"Brain"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0022-510X(90)90133-8","volume":"96","author":"C Ponzetto","year":"1990","unstructured":"Ponzetto C, Bresolin N, Bordoni A, Moggio M, Meola G, Bet L, Prelle A, Scarlato G (1990) Kearns-Sayre syndrome: different amounts of deleted mitochondrial DNA are present in several autoptic tissues. J Neurol Sci 96: 207?210","journal-title":"J Neurol Sci"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1212\/WNL.38.2.244","volume":"38","author":"H Reichmann","year":"1988","unstructured":"Reichmann H (1988) Enzyme activity measured in single muscle fibers in partial COX deficiency. Neurology 38: 244?249","journal-title":"Neurology"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.239.4839.487","volume":"239","author":"RK Saiki","year":"1988","unstructured":"Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA (1988) Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239: 487?494","journal-title":"Science"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.2711184","volume":"244","author":"EA Schon","year":"1989","unstructured":"Schon EA, Rizzuto R, Moraes CT, Nakase H, Zeviani M, Di Mauro S (1989) A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA. Science 244: 346?349","journal-title":"Science"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0092-8674(90)90238-A","volume":"62","author":"EA Shoubridge","year":"1990","unstructured":"Shoubridge EA, Karpati G, Hastings KEM (1990) Deletion mutants are functionally dominant over wild-type mitochondrial diseases. Cell 62: 43?49","journal-title":"Cell"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00291041","volume":"98","author":"D Tautz","year":"1989","unstructured":"Tautz D, Pfeifle C (1989) A non radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98: 81?85","journal-title":"Chromosoma"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1212\/WNL.38.9.1339","volume":"38","author":"M Zeviani","year":"1988","unstructured":"Zeviani M, Moraes CT, DiMauro S, Nakase H, Bonilla E, Schon EA, Rowland LP (1988) Deletions of mitochondrial DNA in Kearns-Sayre syndrome. Neurology 38: 1339?1346","journal-title":"Neurology"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00313606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00313606\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00313606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T11:39:26Z","timestamp":1624707566000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00313606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["BF00313606"],"URL":"https:\/\/doi.org\/10.1007\/bf00313606","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}